Hartmann2016 Blood Coagulation Model For Simulating Anticoagulants Lab

About lab

Hartmann2016 Blood Coagulation Model For Simulating Anticoagulants

This Biosimulant lab wraps Hartmann2016 Blood Coagulation Model For Simulating Anticoagulants as a runnable systems biology model with a companion visualization module. Mathematical model of blood coagulation. It can be used to explore the configured dynamics and compare scenario outcomes across configurations.

What You'll See

The lab asks: Which source-defined system states dominate this SBML model trajectory? Source model: Hartmann2016 - Blood coagulation model for simulating anticoagulants. It runs for 1.0 time units with a communication step of 0.1. The run uses the model defaults declared by the curated SBML wrapper. The generated visualizations focus on VK_p, A_riva, Xa_TFPI, Xa_ATIII_Heparin, Va_Xa, and VIIa_TF_Xa_TFPI, combining trajectory, endpoint-comparison, and summary-table views from one completed dark-mode run.

In this captured run, A_riva moved from 1.000 to 0.4066 across 1.0 simulation windows.

Output Visualizations

Hartmann2016 Blood Coagulation Model For Simulating Anticoagulants - run interpretation

Summary table for Hartmann2016 Blood Coagulation Model For Simulating Anticoagulants, reporting the scientific question, observed answer, dominant module, and caveat.

Hartmann2016 Blood Coagulation Model For Simulating Anticoagulants - timeseries visualization

Trajectories of A_riva, VK_p, Xa_TFPI, Va_Xa, Xa_ATIII_Heparin, and VIIa_TF_Xa_TFPI across the 1.0 simulation. In this run VK_p climbed from 115.5 to 115.5 and A_riva fell from 1.000 to 0.4066 — the largest movements among the focused observables.

Hartmann2016 Blood Coagulation Model For Simulating Anticoagulants - excursions bar

Largest-excursion ranking of the focused observables — the absolute movement magnitude during the run. Top 3: A_riva = 0.5934, VK_p = 2.58e-06, Xa_TFPI = 1.93e-22, with 1 more observable below.

Hartmann2016 Blood Coagulation Model For Simulating Anticoagulants - timeseries visualization

Hartmann2016 Blood Coagulation Model For Simulating Anticoagulants - visualization

Visualization card from the Hartmann2016 Blood Coagulation Model For Simulating Anticoagulants dark-mode run.

Model Context

Core model: models/core
Visualization model: models/visualisation
Standard: other
Upstream source: biomodels_ebi:MODEL1807180004
License: CC0

Inputs

Input	Maps To	Default	Notes
Riva Daily Dose	`systemsbiology_sbml_hartmann2016_blood_coagulation_model_for_simulat_model1807180004_model.riva_daily_dose`		Source parameter exposed because its SBML label indicates a boundary, stimulus, dose, ligand, protocol, substrate, or environmental control. Maps to SBML symbol `Riva_daily_dose`.
Warfarin Daily Dose	`systemsbiology_sbml_hartmann2016_blood_coagulation_model_for_simulat_model1807180004_model.warfarin_daily_dose`		Source parameter exposed because its SBML label indicates a boundary, stimulus, dose, ligand, protocol, substrate, or environmental control. Maps to SBML symbol `warfarin_daily_dose`.

Outputs

Output	Maps To	Role
`state`	`systemsbiology_sbml_hartmann2016_blood_coagulation_model_for_simulat_model1807180004_model.state`	Available to the visualization model and downstream workflows.
`summary`	`systemsbiology_sbml_hartmann2016_blood_coagulation_model_for_simulat_model1807180004_model.summary`	Available to the visualization model and downstream workflows.
`species_labels`	`systemsbiology_sbml_hartmann2016_blood_coagulation_model_for_simulat_model1807180004_model.species_labels`	Available to the visualization model and downstream workflows.
`vk_p`	`systemsbiology_sbml_hartmann2016_blood_coagulation_model_for_simulat_model1807180004_model.vk_p`	Available to the visualization model and downstream workflows.
`a_riva`	`systemsbiology_sbml_hartmann2016_blood_coagulation_model_for_simulat_model1807180004_model.a_riva`	Available to the visualization model and downstream workflows.
`xa_tfpi`	`systemsbiology_sbml_hartmann2016_blood_coagulation_model_for_simulat_model1807180004_model.xa_tfpi`	Available to the visualization model and downstream workflows.
`xa_atiii_heparin`	`systemsbiology_sbml_hartmann2016_blood_coagulation_model_for_simulat_model1807180004_model.xa_atiii_heparin`	Available to the visualization model and downstream workflows.
`va_xa`	`systemsbiology_sbml_hartmann2016_blood_coagulation_model_for_simulat_model1807180004_model.va_xa`	Available to the visualization model and downstream workflows.
`vi_ia_tf_xa_tfpi`	`systemsbiology_sbml_hartmann2016_blood_coagulation_model_for_simulat_model1807180004_model.vi_ia_tf_xa_tfpi`	Available to the visualization model and downstream workflows.

Runtime

Duration: 1.0
Communication step: 0.1

Running Locally

biosimulant labs serve

Mathematical model of blood coagulation. It can be used to explore systemsbiology hartmann2016 blood coagulation for simulat dynamics and compare simulation behavior across conditions.

Runtime

Duration1

Comms Step0.1

Runs

Total0

Completed0

Failed0

Metadata

Packagehartmann2016-blood-coagulation-model-for-simulating-anticoagulan

Created2026-05-17

Updated2026-05-17

systemsbiologysbmlbiomodels_ebifaithfulcuratedvisualisation

Manifest

{
  "io": {
    "inputs": [
      {
        "name": "riva_daily_dose",
        "label": "Riva Daily Dose",
        "maps_to": "systemsbiology_sbml_hartmann2016_blood_coagulation_model_for_simulat_model1807180004_model.riva_daily_dose",
        "description": "Source parameter exposed because its SBML label indicates a boundary, stimulus, dose, ligand, protocol, substrate, or environmental control. Maps to SBML symbol `Riva_daily_dose`."
      },
      {
        "name": "warfarin_daily_dose",
        "label": "Warfarin Daily Dose",
        "maps_to": "systemsbiology_sbml_hartmann2016_blood_coagulation_model_for_simulat_model1807180004_model.warfarin_daily_dose",
        "description": "Source parameter exposed because its SBML label indicates a boundary, stimulus, dose, ligand, protocol, substrate, or environmental control. Maps to SBML symbol `warfarin_daily_dose`."
      }
    ],
    "outputs": [
      {
        "name": "state",
        "maps_to": "systemsbiology_sbml_hartmann2016_blood_coagulation_model_for_simulat_model1807180004_model.state"
      },
      {
        "name": "summary",
        "maps_to": "systemsbiology_sbml_hartmann2016_blood_coagulation_model_for_simulat_model1807180004_model.summary"
      },
      {
        "name": "species_labels",
        "maps_to": "systemsbiology_sbml_hartmann2016_blood_coagulation_model_for_simulat_model1807180004_model.species_labels"
      },
      {
        "name": "vk_p",
        "maps_to": "systemsbiology_sbml_hartmann2016_blood_coagulation_model_for_simulat_model1807180004_model.vk_p"
      },
      {
        "name": "a_riva",
        "maps_to": "systemsbiology_sbml_hartmann2016_blood_coagulation_model_for_simulat_model1807180004_model.a_riva"
      },
      {
        "name": "xa_tfpi",
        "maps_to": "systemsbiology_sbml_hartmann2016_blood_coagulation_model_for_simulat_model1807180004_model.xa_tfpi"
      },
      {
        "name": "xa_atiii_heparin",
        "maps_to": "systemsbiology_sbml_hartmann2016_blood_coagulation_model_for_simulat_model1807180004_model.xa_atiii_heparin"
      },
      {
        "name": "va_xa",
        "maps_to": "systemsbiology_sbml_hartmann2016_blood_coagulation_model_for_simulat_model1807180004_model.va_xa"
      },
      {
        "name": "vi_ia_tf_xa_tfpi",
        "maps_to": "systemsbiology_sbml_hartmann2016_blood_coagulation_model_for_simulat_model1807180004_model.vi_ia_tf_xa_tfpi"
      }
    ]
  },
  "tags": [
    "systemsbiology",
    "sbml",
    "biomodels_ebi",
    "faithful",
    "curated"
  ],
  "title": "Hartmann2016 Blood Coagulation Model For Simulating Anticoagulants Lab",
  "models": [
    {
      "path": "owned/models/systemsbiology_sbml_hartmann2016_blood_coagulation_model_for_simulat_model1807180004_model",
      "alias": "systemsbiology_sbml_hartmann2016_blood_coagulation_model_for_simulat_model1807180004_model",
      "provenance": {
        "owned_path": "owned/models/systemsbiology_sbml_hartmann2016_blood_coagulation_model_for_simulat_model1807180004_model"
      }
    },
    {
      "path": "owned/models/visualisation",
      "alias": "visualisation",
      "provenance": {
        "owned_path": "owned/models/visualisation"
      }
    }
  ],
  "wiring": [
    {
      "to": [
        "visualisation.systemsbiology_sbml_hartmann2016_blood_coagulation_model_for_simulat_model1807180004_model_state"
      ],
      "from": "systemsbiology_sbml_hartmann2016_blood_coagulation_model_for_simulat_model1807180004_model.state"
    },
    {
      "to": [
        "visualisation.systemsbiology_sbml_hartmann2016_blood_coagulation_model_for_simulat_model1807180004_model_summary"
      ],
      "from": "systemsbiology_sbml_hartmann2016_blood_coagulation_model_for_simulat_model1807180004_model.summary"
    },
    {
      "to": [
        "visualisation.systemsbiology_sbml_hartmann2016_blood_coagulation_model_for_simulat_model1807180004_model_species_labels"
      ],
      "from": "systemsbiology_sbml_hartmann2016_blood_coagulation_model_for_simulat_model1807180004_model.species_labels"
    }
  ],
  "runtime": {
    "duration": 1,
    "initial_inputs": {},
    "communication_step": 0.1
  },
  "description": "Mathematical model of blood coagulation. It can be used to explore systemsbiology hartmann2016 blood coagulation for simulat dynamics and compare simulation behavior across conditions.",
  "schema_version": "2.0"
}

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