Davies2023 - Cholesterol Metabolism and Atherosclerosis Model Lab

{
  "io": {
    "inputs": [
      {
        "name": "initial_lipid_metabolism_state_1",
        "units": "native SBML value",
        "default": 3150,
        "maps_to": "metabolism_sbml_davies2023_cholesterol_metabolism_and_atheroscle_model2306300001_model.initial_lipid_metabolism_state_1",
        "description": "Initial condition for lipid metabolism state 1. Maps to bundled SBML symbol `species_2`. Applied before the Tellurium simulation starts; this does not change kinetic parameters or equations. Default from bundled SBML initial value."
      },
      {
        "name": "initial_lipid_metabolism_state_2",
        "units": "native SBML value",
        "default": 400,
        "maps_to": "metabolism_sbml_davies2023_cholesterol_metabolism_and_atheroscle_model2306300001_model.initial_lipid_metabolism_state_2",
        "description": "Initial condition for lipid metabolism state 2. Maps to bundled SBML symbol `species_4`. Applied before the Tellurium simulation starts; this does not change kinetic parameters or equations. Default from bundled SBML initial value."
      },
      {
        "name": "initial_lipid_metabolism_state_3",
        "units": "native SBML value",
        "default": 467,
        "maps_to": "metabolism_sbml_davies2023_cholesterol_metabolism_and_atheroscle_model2306300001_model.initial_lipid_metabolism_state_3",
        "description": "Initial condition for lipid metabolism state 3. Maps to bundled SBML symbol `species_5`. Applied before the Tellurium simulation starts; this does not change kinetic parameters or equations. Default from bundled SBML initial value."
      },
      {
        "name": "initial_lipid_metabolism_state_4",
        "units": "native SBML value",
        "default": 60000,
        "maps_to": "metabolism_sbml_davies2023_cholesterol_metabolism_and_atheroscle_model2306300001_model.initial_lipid_metabolism_state_4",
        "description": "Initial condition for lipid metabolism state 4. Maps to bundled SBML symbol `species_7`. Applied before the Tellurium simulation starts; this does not change kinetic parameters or equations. Default from bundled SBML initial value."
      },
      {
        "name": "initial_lipid_metabolism_state_5",
        "units": "native SBML value",
        "default": 100,
        "maps_to": "metabolism_sbml_davies2023_cholesterol_metabolism_and_atheroscle_model2306300001_model.initial_lipid_metabolism_state_5",
        "description": "Initial condition for lipid metabolism state 5. Maps to bundled SBML symbol `species_10`. Applied before the Tellurium simulation starts; this does not change kinetic parameters or equations. Default from bundled SBML initial value."
      }
    ],
    "outputs": [
      {
        "name": "lipid_metabolism_state_1",
        "maps_to": "metabolism_sbml_davies2023_cholesterol_metabolism_and_atheroscle_model2306300001_model.lipid_metabolism_state_1"
      },
      {
        "name": "lipid_metabolism_state_2",
        "maps_to": "metabolism_sbml_davies2023_cholesterol_metabolism_and_atheroscle_model2306300001_model.lipid_metabolism_state_2"
      },
      {
        "name": "lipid_metabolism_state_3",
        "maps_to": "metabolism_sbml_davies2023_cholesterol_metabolism_and_atheroscle_model2306300001_model.lipid_metabolism_state_3"
      },
      {
        "name": "lipid_metabolism_state_4",
        "maps_to": "metabolism_sbml_davies2023_cholesterol_metabolism_and_atheroscle_model2306300001_model.lipid_metabolism_state_4"
      },
      {
        "name": "lipid_metabolism_state_5",
        "maps_to": "metabolism_sbml_davies2023_cholesterol_metabolism_and_atheroscle_model2306300001_model.lipid_metabolism_state_5"
      },
      {
        "name": "observable_values",
        "maps_to": "metabolism_sbml_davies2023_cholesterol_metabolism_and_atheroscle_model2306300001_model.observable_values"
      },
      {
        "name": "run_summary",
        "maps_to": "metabolism_sbml_davies2023_cholesterol_metabolism_and_atheroscle_model2306300001_model.run_summary"
      },
      {
        "name": "observable_labels",
        "maps_to": "metabolism_sbml_davies2023_cholesterol_metabolism_and_atheroscle_model2306300001_model.observable_labels"
      }
    ]
  },
  "title": "Davies2023 - Cholesterol Metabolism and Atherosclerosis Model Lab",
  "models": [
    {
      "path": "owned/models/metabolism_sbml_davies2023_cholesterol_metabolism_and_atheroscle_model2306300001_model",
      "alias": "metabolism_sbml_davies2023_cholesterol_metabolism_and_atheroscle_model2306300001_model",
      "parameters": {
        "model_path": "data/MODEL2306300001.xml",
        "integration_step": 0.1
      },
      "provenance": {
        "owned_path": "owned/models/metabolism_sbml_davies2023_cholesterol_metabolism_and_atheroscle_model2306300001_model"
      }
    },
    {
      "path": "owned/models/visualisation",
      "alias": "visualisation",
      "provenance": {
        "owned_path": "owned/models/visualisation"
      }
    }
  ],
  "wiring": [
    {
      "to": [
        "visualisation.metabolism_sbml_davies2023_cholesterol_metabolism_and_atheroscle_model2306300001_model_observable_values"
      ],
      "from": "metabolism_sbml_davies2023_cholesterol_metabolism_and_atheroscle_model2306300001_model.observable_values"
    },
    {
      "to": [
        "visualisation.metabolism_sbml_davies2023_cholesterol_metabolism_and_atheroscle_model2306300001_model_run_summary"
      ],
      "from": "metabolism_sbml_davies2023_cholesterol_metabolism_and_atheroscle_model2306300001_model.run_summary"
    },
    {
      "to": [
        "visualisation.metabolism_sbml_davies2023_cholesterol_metabolism_and_atheroscle_model2306300001_model_observable_labels"
      ],
      "from": "metabolism_sbml_davies2023_cholesterol_metabolism_and_atheroscle_model2306300001_model.observable_labels"
    }
  ],
  "runtime": {
    "duration": 10,
    "initial_inputs": {},
    "communication_step": 1
  },
  "description": "Merged model of whole body cholesterol metabolism (BIOMD0000000434) and atherosclerosis (MODEL1002160000). It can be used to explore metabolic flux dynamics and compare pathway behavior across conditions.",
  "schema_version": "2.0"
}