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Dallepezze2014 Cellular Senescene Induced Mitochondrial Dysfunction Lab

About lab

DallePazze2014 - Cellular senescene-inducedmitochondrial dysfunction This model is described in the article: Dynamic modelling of pathways to cellular senescence reveals strategies for targeted interv. It can be used to explore systemsbiology dallepezze2014 cellular senescene induced mitoch dynamics and compare simulation behavior across conditions.

Runtime

Duration1
Comms Step0.1

Runs

Total0
Completed0
Failed0

Metadata

Packagedallepezze2014-cellular-senescene-induced-mitochondrial-dysfunct
Created2026-05-17
Updated2026-05-17
metabolismsystemsbiologysbmlbiomodels_ebifaithfulcuratedvisualisation

Manifest

{
  "io": {
    "inputs": [
      {
        "name": "akt_s473_phos_by_insulin",
        "label": "Akt S473 Phos By Insulin",
        "maps_to": "systemsbiology_sbml_dallepezze2014_cellular_senescene_induced_mitoch_biomd0000000582_model.akt_s473_phos_by_insulin",
        "description": "Source parameter exposed because its SBML label indicates a boundary, stimulus, dose, ligand, protocol, substrate, or environmental control. Maps to SBML symbol `Akt_S473_phos_by_insulin`."
      }
    ],
    "outputs": [
      {
        "name": "state",
        "maps_to": "systemsbiology_sbml_dallepezze2014_cellular_senescene_induced_mitoch_biomd0000000582_model.state"
      },
      {
        "name": "summary",
        "maps_to": "systemsbiology_sbml_dallepezze2014_cellular_senescene_induced_mitoch_biomd0000000582_model.summary"
      },
      {
        "name": "species_labels",
        "maps_to": "systemsbiology_sbml_dallepezze2014_cellular_senescene_induced_mitoch_biomd0000000582_model.species_labels"
      },
      {
        "name": "m_tor_p_s2448_obs",
        "maps_to": "systemsbiology_sbml_dallepezze2014_cellular_senescene_induced_mitoch_biomd0000000582_model.m_tor_p_s2448_obs"
      },
      {
        "name": "m_torc1_p_s2448",
        "maps_to": "systemsbiology_sbml_dallepezze2014_cellular_senescene_induced_mitoch_biomd0000000582_model.m_torc1_p_s2448"
      },
      {
        "name": "m_torc1",
        "maps_to": "systemsbiology_sbml_dallepezze2014_cellular_senescene_induced_mitoch_biomd0000000582_model.m_torc1"
      },
      {
        "name": "mito_mass_turnover",
        "maps_to": "systemsbiology_sbml_dallepezze2014_cellular_senescene_induced_mitoch_biomd0000000582_model.mito_mass_turnover"
      },
      {
        "name": "fox_o3a_total_obs",
        "maps_to": "systemsbiology_sbml_dallepezze2014_cellular_senescene_induced_mitoch_biomd0000000582_model.fox_o3a_total_obs"
      },
      {
        "name": "mito_membr_pot_new",
        "maps_to": "systemsbiology_sbml_dallepezze2014_cellular_senescene_induced_mitoch_biomd0000000582_model.mito_membr_pot_new"
      }
    ]
  },
  "tags": [
    "metabolism",
    "systemsbiology",
    "sbml",
    "biomodels_ebi",
    "faithful",
    "curated"
  ],
  "title": "Dallepezze2014 Cellular Senescene Induced Mitochondrial Dysfunction Lab",
  "models": [
    {
      "path": "owned/models/systemsbiology_sbml_dallepezze2014_cellular_senescene_induced_mitoch_biomd0000000582_model",
      "alias": "systemsbiology_sbml_dallepezze2014_cellular_senescene_induced_mitoch_biomd0000000582_model",
      "provenance": {
        "owned_path": "owned/models/systemsbiology_sbml_dallepezze2014_cellular_senescene_induced_mitoch_biomd0000000582_model"
      }
    },
    {
      "path": "owned/models/visualisation",
      "alias": "visualisation",
      "provenance": {
        "owned_path": "owned/models/visualisation"
      }
    }
  ],
  "wiring": [
    {
      "to": [
        "visualisation.systemsbiology_sbml_dallepezze2014_cellular_senescene_induced_mitoch_biomd0000000582_model_state"
      ],
      "from": "systemsbiology_sbml_dallepezze2014_cellular_senescene_induced_mitoch_biomd0000000582_model.state"
    },
    {
      "to": [
        "visualisation.systemsbiology_sbml_dallepezze2014_cellular_senescene_induced_mitoch_biomd0000000582_model_summary"
      ],
      "from": "systemsbiology_sbml_dallepezze2014_cellular_senescene_induced_mitoch_biomd0000000582_model.summary"
    },
    {
      "to": [
        "visualisation.systemsbiology_sbml_dallepezze2014_cellular_senescene_induced_mitoch_biomd0000000582_model_species_labels"
      ],
      "from": "systemsbiology_sbml_dallepezze2014_cellular_senescene_induced_mitoch_biomd0000000582_model.species_labels"
    }
  ],
  "runtime": {
    "duration": 1,
    "initial_inputs": {},
    "communication_step": 0.1
  },
  "description": "DallePazze2014 - Cellular senescene-inducedmitochondrial dysfunction This model is described in the article: Dynamic modelling of pathways to cellular senescence reveals strategies for targeted interv. It can be used to explore systemsbiology dallepezze2014 cellular senescene induced mitoch dynamics and compare simulation behavior across conditions.",
  "schema_version": "2.0"
}

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