Raia2010 - IL13 Signalling MedB1 Lab

{
  "io": {
    "inputs": [
      {
        "name": "kon_il13_rec_source_parameter",
        "label": "Kon IL13Rec source parameter",
        "units": "native SBML value",
        "default": 0.00341992,
        "maps_to": "oncology_sbml_raia2010_il13_signalling_medb1_biomd0000000313_model.kon_il13_rec_source_parameter",
        "description": "Kon IL13Rec source parameter. Maps to bundled SBML parameter `Kon_IL13Rec`."
      },
      {
        "name": "il13stimulation_source_parameter",
        "label": "IL13stimulation source parameter",
        "units": "native SBML value",
        "default": 1,
        "maps_to": "oncology_sbml_raia2010_il13_signalling_medb1_biomd0000000313_model.il13stimulation_source_parameter",
        "description": "IL13stimulation source parameter. Maps to bundled SBML parameter `IL13stimulation`."
      },
      {
        "name": "initial_stat5",
        "label": "STAT5",
        "units": "native SBML value",
        "default": 165,
        "maps_to": "oncology_sbml_raia2010_il13_signalling_medb1_biomd0000000313_model.initial_stat5",
        "description": "Initial STAT5. Sets the initial value of bundled SBML symbol `STAT5`."
      },
      {
        "name": "initial_pstat5",
        "label": "PSTAT5",
        "units": "native SBML value",
        "default": 0,
        "maps_to": "oncology_sbml_raia2010_il13_signalling_medb1_biomd0000000313_model.initial_pstat5",
        "description": "Initial PSTAT5. Sets the initial value of bundled SBML symbol `pSTAT5`."
      },
      {
        "name": "initial_rec",
        "label": "Rec",
        "units": "native SBML value",
        "default": 1.3,
        "maps_to": "oncology_sbml_raia2010_il13_signalling_medb1_biomd0000000313_model.initial_rec",
        "description": "Initial Rec. Sets the initial value of bundled SBML symbol `Rec`."
      },
      {
        "name": "initial_jak2",
        "label": "JAK2",
        "units": "native SBML value",
        "default": 2.8,
        "maps_to": "oncology_sbml_raia2010_il13_signalling_medb1_biomd0000000313_model.initial_jak2",
        "description": "Initial JAK2. Sets the initial value of bundled SBML symbol `JAK2`."
      }
    ],
    "outputs": [
      {
        "name": "stat5",
        "maps_to": "oncology_sbml_raia2010_il13_signalling_medb1_biomd0000000313_model.stat5",
        "description": "STAT5 observable. Maps to SBML symbol `STAT5`."
      },
      {
        "name": "pstat5",
        "maps_to": "oncology_sbml_raia2010_il13_signalling_medb1_biomd0000000313_model.pstat5",
        "description": "PSTAT5 observable. Maps to SBML symbol `pSTAT5`."
      },
      {
        "name": "rec",
        "maps_to": "oncology_sbml_raia2010_il13_signalling_medb1_biomd0000000313_model.rec",
        "description": "Rec observable. Maps to SBML symbol `Rec`."
      },
      {
        "name": "jak2",
        "maps_to": "oncology_sbml_raia2010_il13_signalling_medb1_biomd0000000313_model.jak2",
        "description": "JAK2 observable. Maps to SBML symbol `JAK2`."
      },
      {
        "name": "shp1",
        "maps_to": "oncology_sbml_raia2010_il13_signalling_medb1_biomd0000000313_model.shp1",
        "description": "SHP1 observable. Maps to SBML symbol `SHP1`."
      },
      {
        "name": "rec_i",
        "maps_to": "oncology_sbml_raia2010_il13_signalling_medb1_biomd0000000313_model.rec_i",
        "description": "Rec i observable. Maps to SBML symbol `Rec_i`."
      },
      {
        "name": "state",
        "maps_to": "oncology_sbml_raia2010_il13_signalling_medb1_biomd0000000313_model.state",
        "description": "Full raw SBML observable record for reproducibility and downstream visualisation."
      },
      {
        "name": "summary",
        "maps_to": "oncology_sbml_raia2010_il13_signalling_medb1_biomd0000000313_model.summary",
        "description": "Change and peak summary across the simulated SBML observables."
      },
      {
        "name": "species_labels",
        "maps_to": "oncology_sbml_raia2010_il13_signalling_medb1_biomd0000000313_model.species_labels",
        "description": "Mapping from selected raw SBML observable symbols to display labels."
      }
    ]
  },
  "tags": [
    "biomodels_ebi",
    "curated",
    "drug-response",
    "faithful",
    "oncology",
    "pharmacology",
    "physiology",
    "sbml",
    "signal-transduction",
    "signaling",
    "systemsbiology",
    "tumor-growth"
  ],
  "title": "Raia2010 - IL13 Signalling MedB1 Lab",
  "models": [
    {
      "path": "owned/models/oncology_sbml_raia2010_il13_signalling_medb1_biomd0000000313_model",
      "alias": "oncology_sbml_raia2010_il13_signalling_medb1_biomd0000000313_model",
      "provenance": {
        "owned_path": "owned/models/oncology_sbml_raia2010_il13_signalling_medb1_biomd0000000313_model"
      }
    },
    {
      "path": "owned/models/visualisation",
      "alias": "visualisation",
      "provenance": {
        "owned_path": "owned/models/visualisation"
      }
    }
  ],
  "wiring": [
    {
      "to": [
        "visualisation.oncology_sbml_raia2010_il13_signalling_medb1_biomd0000000313_model_state"
      ],
      "from": "oncology_sbml_raia2010_il13_signalling_medb1_biomd0000000313_model.state"
    },
    {
      "to": [
        "visualisation.oncology_sbml_raia2010_il13_signalling_medb1_biomd0000000313_model_summary"
      ],
      "from": "oncology_sbml_raia2010_il13_signalling_medb1_biomd0000000313_model.summary"
    },
    {
      "to": [
        "visualisation.oncology_sbml_raia2010_il13_signalling_medb1_biomd0000000313_model_species_labels"
      ],
      "from": "oncology_sbml_raia2010_il13_signalling_medb1_biomd0000000313_model.species_labels"
    }
  ],
  "runtime": {
    "duration": 10,
    "initial_inputs": {},
    "communication_step": 1
  },
  "description": "This is the model of IL13 induced signalling in MedB-1 cell described in the article: Dynamic Mathematical Modeling of IL13-Induced Signaling in Hodgkin and Primary Mediastinal B-Cell Lymphoma Allows. It can be used to explore tumor-related dynamics and compare treatment-response behavior across conditions.",
  "schema_version": "2.0"
}