Leber2016 Follicular T Cell Differentiation Lab

{
  "io": {
    "inputs": [
      {
        "name": "interleukin_2_signal",
        "label": "IL-2 signal",
        "units": "native SBML value",
        "default": 0.0001,
        "maps_to": "leber2016_follicular_t_cell_differentiation.interleukin_2_signal",
        "description": "Sets the constant IL-2 upstream signal in the Tfh/Tfr differentiation network. Maps to SBML symbol `IL2`."
      },
      {
        "name": "stat5_signal",
        "label": "STAT5 signal",
        "units": "native SBML value",
        "default": 0,
        "maps_to": "leber2016_follicular_t_cell_differentiation.stat5_signal",
        "description": "Sets the constant STAT5 upstream signal in the Tfh/Tfr differentiation network. Maps to SBML symbol `STAT5`."
      }
    ],
    "outputs": [
      {
        "name": "naive_cluster_of_differentiation_four_t_cells",
        "label": "Naive CD4 T cells",
        "maps_to": "leber2016_follicular_t_cell_differentiation.naive_cluster_of_differentiation_four_t_cells",
        "description": "Naive CD4 T cells. Maps to SBML symbol `NaiveCD4`."
      },
      {
        "name": "natural_regulatory_t_cells",
        "label": "Natural regulatory T cells",
        "maps_to": "leber2016_follicular_t_cell_differentiation.natural_regulatory_t_cells",
        "description": "Natural regulatory T cells. Maps to SBML symbol `nTreg`."
      },
      {
        "name": "follicular_helper_t_cells",
        "label": "Follicular helper T cells",
        "maps_to": "leber2016_follicular_t_cell_differentiation.follicular_helper_t_cells",
        "description": "Follicular helper T cells. Maps to SBML symbol `Tfh`."
      },
      {
        "name": "follicular_regulatory_t_cells",
        "label": "Follicular regulatory T cells",
        "maps_to": "leber2016_follicular_t_cell_differentiation.follicular_regulatory_t_cells",
        "description": "Follicular regulatory T cells. Maps to SBML symbol `Tfr`."
      },
      {
        "name": "b_cell_lymphoma_six",
        "label": "Bcl6",
        "maps_to": "leber2016_follicular_t_cell_differentiation.b_cell_lymphoma_six",
        "description": "Bcl6. Maps to SBML symbol `Bcl6`."
      },
      {
        "name": "b_lymphocyte_induced_maturation_protein_one",
        "label": "Blimp1",
        "maps_to": "leber2016_follicular_t_cell_differentiation.b_lymphocyte_induced_maturation_protein_one",
        "description": "Blimp1. Maps to SBML symbol `Blimp1`."
      },
      {
        "name": "forkhead_box_p3",
        "label": "FOXP3",
        "maps_to": "leber2016_follicular_t_cell_differentiation.forkhead_box_p3",
        "description": "FOXP3. Maps to SBML symbol `FoxP3`."
      },
      {
        "name": "signal_transducer_and_activator_of_transcription_3",
        "label": "STAT3",
        "maps_to": "leber2016_follicular_t_cell_differentiation.signal_transducer_and_activator_of_transcription_3",
        "description": "STAT3. Maps to SBML symbol `STAT3`."
      },
      {
        "name": "interleukin_6",
        "label": "IL-6",
        "maps_to": "leber2016_follicular_t_cell_differentiation.interleukin_6",
        "description": "IL-6. Maps to SBML symbol `IL6`."
      },
      {
        "name": "interleukin_21",
        "label": "IL-21",
        "maps_to": "leber2016_follicular_t_cell_differentiation.interleukin_21",
        "description": "IL-21. Maps to SBML symbol `IL21`."
      },
      {
        "name": "state",
        "maps_to": "leber2016_follicular_t_cell_differentiation.state",
        "description": "Full friendly observable record."
      },
      {
        "name": "summary",
        "maps_to": "leber2016_follicular_t_cell_differentiation.summary",
        "description": "Core model run summary."
      },
      {
        "name": "species_labels",
        "maps_to": "leber2016_follicular_t_cell_differentiation.species_labels",
        "description": "Friendly observable display labels."
      }
    ]
  },
  "title": "Leber2016 Follicular T Cell Differentiation Lab",
  "models": [
    {
      "path": "models/core",
      "alias": "leber2016_follicular_t_cell_differentiation",
      "parameters": {
        "model_path": "data/BIOMD0000000625.xml",
        "integration_step": 0.1
      }
    },
    {
      "path": "models/visualisation",
      "alias": "visualisation"
    }
  ],
  "wiring": [
    {
      "to": [
        "visualisation.core_state"
      ],
      "from": "leber2016_follicular_t_cell_differentiation.state"
    },
    {
      "to": [
        "visualisation.core_summary"
      ],
      "from": "leber2016_follicular_t_cell_differentiation.summary"
    },
    {
      "to": [
        "visualisation.core_species_labels"
      ],
      "from": "leber2016_follicular_t_cell_differentiation.species_labels"
    }
  ],
  "package": "leber2016-tfh-tfr-differentiation",
  "runtime": {
    "duration": 10,
    "initial_inputs": {},
    "communication_step": 1
  },
  "version": "1.0.0",
  "description": "Expanded Tfh/Tfr differentiation model for Helicobacter pylori infection executed directly from bundled SBML.",
  "schema_version": "2.0"
}