Gupta2007_HypothalamicPituitaryAdrenal_ModelB Lab

About lab

Gupta2007_HypothalamicPituitaryAdrenal_ModelB

This Biosimulant lab wraps Gupta2007_HypothalamicPituitaryAdrenal_ModelB as a runnable signaling model with a companion visualization module. Clean Biosimulant lab for systems signaling model: Gupta2007_HypothalamicPituitaryAdrenal_ModelB. It can be used to explore second-messenger and pathway-signaling dynamics and compare scenario outcomes across configurations.

What You'll See

The lab asks: How does Gupta2007 HypothalamicPituitaryAdrenal ModelB route receptor activity into cAMP/PKA-linked readouts? It runs for 1.0 time units with a communication step of 0.1. The run uses the model defaults declared by the curated SBML wrapper. The generated visualizations focus on Source Defined C State, Source Defined A State, Source Defined R State, and Source Defined O State, combining trajectory, endpoint-comparison, and summary-table views from one completed dark-mode run.

In this captured run, C moved from 0.6000 to 0.9780 across 1.0 simulation windows.

Output Visualizations

Gupta2007_HypothalamicPituitaryAdrenal_ModelB - run interpretation

Summary table for Gupta2007_HypothalamicPituitaryAdrenal_ModelB, reporting the scientific question, observed answer, dominant module, and caveat.

Gupta2007_HypothalamicPituitaryAdrenal_ModelB - timeseries visualization

Trajectories of C, A, R, and O across the 1.0 simulation. In this run C climbed from 0.6000 to 0.9780 — the largest movements among the focused observables.

Gupta2007_HypothalamicPituitaryAdrenal_ModelB - excursions bar

Largest-excursion ranking of the focused observables — the absolute movement magnitude during the run. Top 3: C = 0.9780, A = 0.0932, O = 0.0698, with 1 more observable below.

Model Context

Core model: models/core
Visualization model: models/visualisation
Standard: other
Upstream source: biomodels_ebi:MODEL1006230036
License: CC0
Visual scope: GPCR and cAMP/PKA signaling
Caveat: Values are native SBML quantities; equations, parameters, units, and initial values remain in the bundled source file.

Inputs

Input	Maps To	Default	Notes
Initial source-defined C state	`signaling_sbml_gupta2007_hypothalamicpituitaryadrenal_modelb_model1006230036_model.initial_source_defined_c_state`		Initial level of source-defined C state. Maps to SBML symbol `c`; exposed as a traceable initial-condition perturbation.

Outputs

Output	Maps To	Role
`source_defined_c_state`	`signaling_sbml_gupta2007_hypothalamicpituitaryadrenal_modelb_model1006230036_model.source_defined_c_state`	source-defined C state.
`source_defined_a_state`	`signaling_sbml_gupta2007_hypothalamicpituitaryadrenal_modelb_model1006230036_model.source_defined_a_state`	source-defined A state.
`source_defined_r_state`	`signaling_sbml_gupta2007_hypothalamicpituitaryadrenal_modelb_model1006230036_model.source_defined_r_state`	source-defined R state.
`state`	`signaling_sbml_gupta2007_hypothalamicpituitaryadrenal_modelb_model1006230036_model.state`	Available to the visualization model and downstream workflows.
`summary`	`signaling_sbml_gupta2007_hypothalamicpituitaryadrenal_modelb_model1006230036_model.summary`	Available to the visualization model and downstream workflows.
`species_labels`	`signaling_sbml_gupta2007_hypothalamicpituitaryadrenal_modelb_model1006230036_model.species_labels`	Available to the visualization model and downstream workflows.

Runtime

Duration: 1.0
Communication step: 0.1

Running Locally

biosimulant labs serve .

Clean Biosimulant lab for systems signaling model: Gupta2007_HypothalamicPituitaryAdrenal_ModelB. Values are native SBML quantities; equations, parameters, and initial values remain in the bundled source file.

Runtime

Duration1

Comms Step0.1

Runs

Total0

Completed0

Failed0

Metadata

Packagegupta2007-hypothalamicpituitaryadrenal-modelb-lab

Created2026-05-16

Updated2026-05-16

signalingsystemssystems-biologysbmlfaithfulbiomodels_ebigpcrhormone-signalingphysiologyvisualisation

Manifest

{
  "io": {
    "inputs": [
      {
        "name": "initial_source_defined_c_state",
        "label": "Initial source-defined C state",
        "maps_to": "signaling_sbml_gupta2007_hypothalamicpituitaryadrenal_modelb_model1006230036_model.initial_source_defined_c_state",
        "description": "Initial level of source-defined C state. Maps to SBML symbol `c`; exposed as a traceable initial-condition perturbation."
      }
    ],
    "outputs": [
      {
        "name": "source_defined_c_state",
        "label": "source-defined C state",
        "maps_to": "signaling_sbml_gupta2007_hypothalamicpituitaryadrenal_modelb_model1006230036_model.source_defined_c_state",
        "description": "source-defined C state. Maps to SBML symbol `c` and is emitted in native SBML units."
      },
      {
        "name": "source_defined_a_state",
        "label": "source-defined A state",
        "maps_to": "signaling_sbml_gupta2007_hypothalamicpituitaryadrenal_modelb_model1006230036_model.source_defined_a_state",
        "description": "source-defined A state. Maps to SBML symbol `a` and is emitted in native SBML units."
      },
      {
        "name": "source_defined_r_state",
        "label": "source-defined R state",
        "maps_to": "signaling_sbml_gupta2007_hypothalamicpituitaryadrenal_modelb_model1006230036_model.source_defined_r_state",
        "description": "source-defined R state. Maps to SBML symbol `r` and is emitted in native SBML units."
      },
      {
        "name": "state",
        "label": "Observable state",
        "maps_to": "signaling_sbml_gupta2007_hypothalamicpituitaryadrenal_modelb_model1006230036_model.state"
      },
      {
        "name": "summary",
        "label": "Simulation summary",
        "maps_to": "signaling_sbml_gupta2007_hypothalamicpituitaryadrenal_modelb_model1006230036_model.summary"
      },
      {
        "name": "species_labels",
        "label": "Observable labels",
        "maps_to": "signaling_sbml_gupta2007_hypothalamicpituitaryadrenal_modelb_model1006230036_model.species_labels"
      }
    ]
  },
  "tags": [
    "signaling",
    "systems",
    "systems-biology",
    "sbml",
    "faithful",
    "biomodels_ebi",
    "gpcr",
    "hormone-signaling",
    "physiology"
  ],
  "title": "Gupta2007_HypothalamicPituitaryAdrenal_ModelB Lab",
  "models": [
    {
      "path": "owned/models/signaling_sbml_gupta2007_hypothalamicpituitaryadrenal_modelb_model1006230036_model",
      "alias": "signaling_sbml_gupta2007_hypothalamicpituitaryadrenal_modelb_model1006230036_model",
      "provenance": {
        "owned_path": "owned/models/signaling_sbml_gupta2007_hypothalamicpituitaryadrenal_modelb_model1006230036_model"
      }
    },
    {
      "path": "owned/models/visualisation",
      "alias": "visualisation",
      "provenance": {
        "owned_path": "owned/models/visualisation"
      }
    }
  ],
  "wiring": [
    {
      "to": [
        "visualisation.signaling_sbml_gupta2007_hypothalamicpituitaryadrenal_modelb_model1006230036_model_state"
      ],
      "from": "signaling_sbml_gupta2007_hypothalamicpituitaryadrenal_modelb_model1006230036_model.state"
    },
    {
      "to": [
        "visualisation.signaling_sbml_gupta2007_hypothalamicpituitaryadrenal_modelb_model1006230036_model_summary"
      ],
      "from": "signaling_sbml_gupta2007_hypothalamicpituitaryadrenal_modelb_model1006230036_model.summary"
    },
    {
      "to": [
        "visualisation.signaling_sbml_gupta2007_hypothalamicpituitaryadrenal_modelb_model1006230036_model_species_labels"
      ],
      "from": "signaling_sbml_gupta2007_hypothalamicpituitaryadrenal_modelb_model1006230036_model.species_labels"
    }
  ],
  "runtime": {
    "duration": 1,
    "initial_inputs": {},
    "communication_step": 0.1
  },
  "description": "Clean Biosimulant lab for systems signaling model: Gupta2007_HypothalamicPituitaryAdrenal_ModelB. Values are native SBML quantities; equations, parameters, and initial values remain in the bundled source file.",
  "schema_version": "2.0"
}

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