Hanson2016 - Toxicity Management in CAR T cell therapy for B-ALL Lab

{
  "io": {
    "inputs": [
      {
        "name": "initial_unresolved_tumor_observable_1",
        "label": "Initial Unresolved Tumor Observable 1",
        "units": "native source value",
        "default": 10,
        "maps_to": "immunology_sbml_hanson2016_toxicity_management_in_car_t_cell_the_biomd0000000837_model.initial_unresolved_tumor_observable_1",
        "description": "Initial Unresolved Tumor Observable 1. Sets the initial value of bundled SBML species `C_m`."
      },
      {
        "name": "initial_unresolved_tumor_observable_2",
        "label": "Initial Unresolved Tumor Observable 2",
        "units": "native source value",
        "default": 10,
        "maps_to": "immunology_sbml_hanson2016_toxicity_management_in_car_t_cell_the_biomd0000000837_model.initial_unresolved_tumor_observable_2",
        "description": "Initial Unresolved Tumor Observable 2. Sets the initial value of bundled SBML species `C_e`."
      },
      {
        "name": "initial_unresolved_tumor_observable_3",
        "label": "Initial Unresolved Tumor Observable 3",
        "units": "native source value",
        "default": 10,
        "maps_to": "immunology_sbml_hanson2016_toxicity_management_in_car_t_cell_the_biomd0000000837_model.initial_unresolved_tumor_observable_3",
        "description": "Initial Unresolved Tumor Observable 3. Sets the initial value of bundled SBML species `H_m`."
      },
      {
        "name": "initial_unresolved_tumor_observable_4",
        "label": "Initial Unresolved Tumor Observable 4",
        "units": "native source value",
        "default": 10,
        "maps_to": "immunology_sbml_hanson2016_toxicity_management_in_car_t_cell_the_biomd0000000837_model.initial_unresolved_tumor_observable_4",
        "description": "Initial Unresolved Tumor Observable 4. Sets the initial value of bundled SBML species `H_e`."
      },
      {
        "name": "initial_unresolved_tumor_observable_5",
        "label": "Initial Unresolved Tumor Observable 5",
        "units": "native source value",
        "default": 1600,
        "maps_to": "immunology_sbml_hanson2016_toxicity_management_in_car_t_cell_the_biomd0000000837_model.initial_unresolved_tumor_observable_5",
        "description": "Initial Unresolved Tumor Observable 5. Sets the initial value of bundled SBML species `L`."
      },
      {
        "name": "tumor_growth_rate",
        "label": "Tumor Growth Rate",
        "units": "native source value",
        "default": 0.003,
        "maps_to": "immunology_sbml_hanson2016_toxicity_management_in_car_t_cell_the_biomd0000000837_model.tumor_growth_rate",
        "description": "Tumor Growth Rate. Sets bundled SBML parameter `r_1`."
      },
      {
        "name": "tumor_killing_c_e_rate",
        "label": "Tumor Killing C E Rate",
        "units": "native source value",
        "default": 0.0002,
        "maps_to": "immunology_sbml_hanson2016_toxicity_management_in_car_t_cell_the_biomd0000000837_model.tumor_killing_c_e_rate",
        "description": "Tumor Killing C E Rate. Sets bundled SBML parameter `d_1`."
      },
      {
        "name": "inflammation_decay_rate",
        "label": "Inflammation Decay Rate",
        "units": "native source value",
        "default": 1.5,
        "maps_to": "immunology_sbml_hanson2016_toxicity_management_in_car_t_cell_the_biomd0000000837_model.inflammation_decay_rate",
        "description": "Inflammation Decay Rate. Sets bundled SBML parameter `d_2`."
      },
      {
        "name": "cytotoxic_t_cells_effector_decay_rate",
        "label": "Cytotoxic T Cells Effector Decay Rate",
        "units": "native source value",
        "default": 0.004,
        "maps_to": "immunology_sbml_hanson2016_toxicity_management_in_car_t_cell_the_biomd0000000837_model.cytotoxic_t_cells_effector_decay_rate",
        "description": "Cytotoxic T Cells Effector Decay Rate. Sets bundled SBML parameter `d_3`."
      },
      {
        "name": "helper_t_cells_effector_decay_rate",
        "label": "Helper T Cells Effector Decay Rate",
        "units": "native source value",
        "default": 0.004,
        "maps_to": "immunology_sbml_hanson2016_toxicity_management_in_car_t_cell_the_biomd0000000837_model.helper_t_cells_effector_decay_rate",
        "description": "Helper T Cells Effector Decay Rate. Sets bundled SBML parameter `d_4`."
      }
    ],
    "outputs": [
      {
        "name": "unresolved_tumor_observable_1",
        "maps_to": "immunology_sbml_hanson2016_toxicity_management_in_car_t_cell_the_biomd0000000837_model.unresolved_tumor_observable_1"
      },
      {
        "name": "unresolved_tumor_observable_2",
        "maps_to": "immunology_sbml_hanson2016_toxicity_management_in_car_t_cell_the_biomd0000000837_model.unresolved_tumor_observable_2"
      },
      {
        "name": "unresolved_tumor_observable_3",
        "maps_to": "immunology_sbml_hanson2016_toxicity_management_in_car_t_cell_the_biomd0000000837_model.unresolved_tumor_observable_3"
      },
      {
        "name": "unresolved_tumor_observable_4",
        "maps_to": "immunology_sbml_hanson2016_toxicity_management_in_car_t_cell_the_biomd0000000837_model.unresolved_tumor_observable_4"
      },
      {
        "name": "unresolved_tumor_observable_5",
        "maps_to": "immunology_sbml_hanson2016_toxicity_management_in_car_t_cell_the_biomd0000000837_model.unresolved_tumor_observable_5"
      },
      {
        "name": "state",
        "maps_to": "immunology_sbml_hanson2016_toxicity_management_in_car_t_cell_the_biomd0000000837_model.state"
      },
      {
        "name": "summary",
        "maps_to": "immunology_sbml_hanson2016_toxicity_management_in_car_t_cell_the_biomd0000000837_model.summary"
      },
      {
        "name": "species_labels",
        "maps_to": "immunology_sbml_hanson2016_toxicity_management_in_car_t_cell_the_biomd0000000837_model.species_labels"
      }
    ]
  },
  "title": "Hanson2016 - Toxicity Management in CAR T cell therapy for B-ALL Lab",
  "models": [
    {
      "path": "models/core",
      "alias": "immunology_sbml_hanson2016_toxicity_management_in_car_t_cell_the_biomd0000000837_model"
    },
    {
      "path": "models/visualisation",
      "alias": "visualisation"
    }
  ],
  "wiring": [
    {
      "to": [
        "visualisation.immunology_sbml_hanson2016_toxicity_management_in_car_t_cell_the_biomd0000000837_model_state"
      ],
      "from": "immunology_sbml_hanson2016_toxicity_management_in_car_t_cell_the_biomd0000000837_model.state"
    },
    {
      "to": [
        "visualisation.immunology_sbml_hanson2016_toxicity_management_in_car_t_cell_the_biomd0000000837_model_summary"
      ],
      "from": "immunology_sbml_hanson2016_toxicity_management_in_car_t_cell_the_biomd0000000837_model.summary"
    },
    {
      "to": [
        "visualisation.immunology_sbml_hanson2016_toxicity_management_in_car_t_cell_the_biomd0000000837_model_species_labels"
      ],
      "from": "immunology_sbml_hanson2016_toxicity_management_in_car_t_cell_the_biomd0000000837_model.species_labels"
    }
  ],
  "package": "hanson2016-toxicity-management-in-car-t-cell-therapy",
  "runtime": {
    "duration": 10,
    "initial_inputs": {},
    "communication_step": 1
  },
  "version": "1.0.0",
  "description": "This model provides an in silico mathematical platform to explore the interactions between chimeric antigen receptor-modified T cells, inflammatory toxicitiy, and the tumour burdens of individual pati. It can be used to explore immune response dynamics and compare pathway-level behavior across conditions.",
  "schema_version": "2.0"
}