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Mukhopadhyay2013 - T cell receptor proximal signaling reveals emergent ultrasensitivity Lab

About lab

Clean Biosimulant lab for immune signaling. Values are native SBML quantities; equations, parameters, and initial values remain in the bundled source file.

Runtime

Duration1
Comms Step0.1

Runs

Total0
Completed0
Failed0

Metadata

Packagemukhopadhyay2013-t-cell-receptor-proximal-signaling-reveals-emer
Created2026-05-16
Updated2026-05-16
signalingsystemssystems-biologysbmlfaithfulbiomodels_ebigpcrimmune-signalingvisualisation

Manifest

{
  "io": {
    "inputs": [
      {
        "name": "initial_s_y1_u_y2_u_y3_u_b_0",
        "label": "Initial S Y1 U Y2 U Y3 U B 0",
        "maps_to": "signaling_sbml_mukhopadhyay2013_t_cell_receptor_proximal_signal_model1604100000_model.initial_s_y1_u_y2_u_y3_u_b_0",
        "description": "Initial level of S Y1 U Y2 U Y3 U B 0. Maps to SBML symbol `S1`; exposed as a traceable initial-condition perturbation."
      }
    ],
    "outputs": [
      {
        "name": "s_y1_u_y2_u_y3_u_b_0",
        "label": "S Y1 U Y2 U Y3 U B 0",
        "maps_to": "signaling_sbml_mukhopadhyay2013_t_cell_receptor_proximal_signal_model1604100000_model.s_y1_u_y2_u_y3_u_b_0",
        "description": "S Y1 U Y2 U Y3 U B 0. Maps to SBML symbol `S1` and is emitted in native SBML units."
      },
      {
        "name": "source_defined_e_b_state",
        "label": "source-defined E(B) state",
        "maps_to": "signaling_sbml_mukhopadhyay2013_t_cell_receptor_proximal_signal_model1604100000_model.source_defined_e_b_state",
        "description": "source-defined E(B) state. Maps to SBML symbol `S2` and is emitted in native SBML units."
      },
      {
        "name": "source_defined_f_b_state",
        "label": "source-defined F(B) state",
        "maps_to": "signaling_sbml_mukhopadhyay2013_t_cell_receptor_proximal_signal_model1604100000_model.source_defined_f_b_state",
        "description": "source-defined F(B) state. Maps to SBML symbol `S3` and is emitted in native SBML units."
      },
      {
        "name": "state",
        "label": "Observable state",
        "maps_to": "signaling_sbml_mukhopadhyay2013_t_cell_receptor_proximal_signal_model1604100000_model.state"
      },
      {
        "name": "summary",
        "label": "Simulation summary",
        "maps_to": "signaling_sbml_mukhopadhyay2013_t_cell_receptor_proximal_signal_model1604100000_model.summary"
      },
      {
        "name": "species_labels",
        "label": "Observable labels",
        "maps_to": "signaling_sbml_mukhopadhyay2013_t_cell_receptor_proximal_signal_model1604100000_model.species_labels"
      }
    ]
  },
  "tags": [
    "signaling",
    "systems",
    "systems-biology",
    "sbml",
    "faithful",
    "biomodels_ebi",
    "gpcr",
    "immune-signaling"
  ],
  "title": "Mukhopadhyay2013 - T cell receptor proximal signaling reveals emergent ultrasensitivity Lab",
  "models": [
    {
      "path": "owned/models/signaling_sbml_mukhopadhyay2013_t_cell_receptor_proximal_signal_model1604100000_model",
      "alias": "signaling_sbml_mukhopadhyay2013_t_cell_receptor_proximal_signal_model1604100000_model",
      "provenance": {
        "owned_path": "owned/models/signaling_sbml_mukhopadhyay2013_t_cell_receptor_proximal_signal_model1604100000_model"
      }
    },
    {
      "path": "owned/models/visualisation",
      "alias": "visualisation",
      "provenance": {
        "owned_path": "owned/models/visualisation"
      }
    }
  ],
  "wiring": [
    {
      "to": [
        "visualisation.signaling_sbml_mukhopadhyay2013_t_cell_receptor_proximal_signal_model1604100000_model_state"
      ],
      "from": "signaling_sbml_mukhopadhyay2013_t_cell_receptor_proximal_signal_model1604100000_model.state"
    },
    {
      "to": [
        "visualisation.signaling_sbml_mukhopadhyay2013_t_cell_receptor_proximal_signal_model1604100000_model_summary"
      ],
      "from": "signaling_sbml_mukhopadhyay2013_t_cell_receptor_proximal_signal_model1604100000_model.summary"
    },
    {
      "to": [
        "visualisation.signaling_sbml_mukhopadhyay2013_t_cell_receptor_proximal_signal_model1604100000_model_species_labels"
      ],
      "from": "signaling_sbml_mukhopadhyay2013_t_cell_receptor_proximal_signal_model1604100000_model.species_labels"
    }
  ],
  "runtime": {
    "duration": 1,
    "initial_inputs": {},
    "communication_step": 0.1
  },
  "description": "Clean Biosimulant lab for immune signaling. Values are native SBML quantities; equations, parameters, and initial values remain in the bundled source file.",
  "schema_version": "2.0"
}

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