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Guyton1972 Stress Relaxation Lab

About lab

Two-model lab for Guyton1972 Stress Relaxation: a core SBML simulator wired into a dedicated visualization sub-model that turns the raw state into friendly timeseries and a plain-language summary. This a model from the article: Circulation: overall regulation. It can be used to explore cardiac dynamics and compare response patterns across conditions.

Runtime

Duration1
Comms Step0.001

Runs

Total0
Completed0
Failed0

Metadata

Packageguyton1972-stress-relaxation-lab
Created2026-05-14
Updated2026-05-14
cardiovascularscenariostimulussbmlbiomodels_ebifaithfulvisualization

Manifest

{
  "io": {
    "inputs": [
      {
        "name": "integration_step",
        "maps_to": "guyton1972_stress_relaxation_core.integration_step"
      },
      {
        "name": "parameter_overrides",
        "maps_to": "guyton1972_stress_relaxation_core.parameter_overrides"
      },
      {
        "name": "initial_conditions",
        "maps_to": "guyton1972_stress_relaxation_core.initial_conditions"
      }
    ],
    "outputs": [
      {
        "name": "scenario_metadata",
        "maps_to": "guyton1972_stress_relaxation_scenario.scenario_metadata"
      },
      {
        "name": "state",
        "maps_to": "guyton1972_stress_relaxation_core.state"
      },
      {
        "name": "run_summary",
        "maps_to": "guyton1972_stress_relaxation_viz.run_summary"
      }
    ]
  },
  "title": "Guyton1972 Stress Relaxation Lab",
  "models": [
    {
      "path": "owned/models/guyton1972_stress_relaxation_scenario",
      "alias": "guyton1972_stress_relaxation_scenario",
      "parameters": {
        "schedule": {
          "effective_volume": {
            "unit": "dimensionless",
            "label": "effective volume",
            "active": true,
            "baseline": 0.743224,
            "recovery": 0.743224,
            "challenge": 0.8547075999999999,
            "description": "Scenario-controlled effective volume value."
          },
          "stress_relaxation_gain": {
            "unit": "dimensionless",
            "label": "stress relaxation gain",
            "active": false,
            "baseline": 5,
            "recovery": 5,
            "challenge": 5,
            "description": "Scenario-controlled stress relaxation gain value."
          },
          "stress_relaxation_gain_2": {
            "unit": "dimensionless",
            "label": "stress relaxation gain 2",
            "active": false,
            "baseline": 10000,
            "recovery": 10000,
            "challenge": 10000,
            "description": "Scenario-controlled stress relaxation gain 2 value."
          }
        },
        "scenario_name": "Effective volume challenge",
        "baseline_until": 0.25,
        "challenge_until": 0.75,
        "scenario_description": "Baseline is followed by a effective volume challenge and recovery period."
      },
      "provenance": {
        "owned_path": "owned/models/guyton1972_stress_relaxation_scenario"
      }
    },
    {
      "path": "owned/models/guyton1972_stress_relaxation_core",
      "alias": "guyton1972_stress_relaxation_core",
      "parameters": {
        "model_path": "data/MODEL0910896131.xml",
        "integration_step": 0.001
      },
      "provenance": {
        "owned_path": "owned/models/guyton1972_stress_relaxation_core"
      }
    },
    {
      "path": "owned/models/guyton1972_stress_relaxation_viz",
      "alias": "guyton1972_stress_relaxation_viz",
      "parameters": {
        "lab_title": "Guyton1972 Stress Relaxation",
        "lab_question": "Does vascular stress relaxation buffer pressure?",
        "integration_step": 0.001
      },
      "provenance": {
        "owned_path": "owned/models/guyton1972_stress_relaxation_viz"
      }
    }
  ],
  "wiring": [
    {
      "to": [
        "guyton1972_stress_relaxation_core.effective_volume"
      ],
      "from": "guyton1972_stress_relaxation_scenario.effective_volume"
    },
    {
      "to": [
        "guyton1972_stress_relaxation_core.stress_relaxation_gain"
      ],
      "from": "guyton1972_stress_relaxation_scenario.stress_relaxation_gain"
    },
    {
      "to": [
        "guyton1972_stress_relaxation_core.stress_relaxation_gain_2"
      ],
      "from": "guyton1972_stress_relaxation_scenario.stress_relaxation_gain_2"
    },
    {
      "to": [
        "guyton1972_stress_relaxation_viz.scenario_metadata"
      ],
      "from": "guyton1972_stress_relaxation_scenario.scenario_metadata"
    },
    {
      "to": [
        "guyton1972_stress_relaxation_viz.state"
      ],
      "from": "guyton1972_stress_relaxation_core.state"
    },
    {
      "to": [
        "guyton1972_stress_relaxation_viz.species_labels"
      ],
      "from": "guyton1972_stress_relaxation_core.species_labels"
    }
  ],
  "runtime": {
    "duration": 1,
    "initial_inputs": {
      "guyton1972_stress_relaxation_core": {
        "integration_step": 0.001,
        "initial_conditions": {
          "payload": {}
        },
        "parameter_overrides": {
          "payload": {}
        }
      }
    },
    "communication_step": 0.001
  },
  "description": "Two-model lab for Guyton1972 Stress Relaxation: a core SBML simulator wired into a dedicated visualization sub-model that turns the raw state into friendly timeseries and a plain-language summary. This a model from the article: Circulation: overall regulation. It can be used to explore cardiac dynamics and compare response patterns across conditions.",
  "schema_version": "2.0"
}

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