Hu2018 - Dynamics of tumor-CD4+-cytokine-host cells interactions with treatments Lab

{
  "io": {
    "inputs": [
      {
        "name": "initial_tumor_cells",
        "label": "Initial Tumor Cells",
        "units": "native source value",
        "default": 67700,
        "maps_to": "immunology_sbml_hu2018_dynamics_of_tumor_cd4_cytokine_host_cells_biomd0000000797_model.initial_tumor_cells",
        "description": "Initial Tumor Cells. Sets the initial value of bundled SBML species `x_Tumor_Cells`."
      },
      {
        "name": "initial_cd4_t_cells",
        "label": "Initial CD4 T Cells",
        "units": "native source value",
        "default": 1000000,
        "maps_to": "immunology_sbml_hu2018_dynamics_of_tumor_cd4_cytokine_host_cells_biomd0000000797_model.initial_cd4_t_cells",
        "description": "Initial CD4 T Cells. Sets the initial value of bundled SBML species `y_CD4_T_Cells`."
      },
      {
        "name": "initial_cytokine",
        "label": "Initial Cytokine",
        "units": "native source value",
        "default": 100000,
        "maps_to": "immunology_sbml_hu2018_dynamics_of_tumor_cd4_cytokine_host_cells_biomd0000000797_model.initial_cytokine",
        "description": "Initial Cytokine. Sets the initial value of bundled SBML species `z_Cytokine`."
      },
      {
        "name": "initial_healthy_tissue",
        "label": "Initial Healthy Tissue",
        "units": "native source value",
        "default": 1000000000,
        "maps_to": "immunology_sbml_hu2018_dynamics_of_tumor_cd4_cytokine_host_cells_biomd0000000797_model.initial_healthy_tissue",
        "description": "Initial Healthy Tissue. Sets the initial value of bundled SBML species `w_Healthy_Tissue`."
      },
      {
        "name": "tumor_growth_rate",
        "label": "Tumor Growth Rate",
        "units": "native source value",
        "default": 0.514,
        "maps_to": "immunology_sbml_hu2018_dynamics_of_tumor_cd4_cytokine_host_cells_biomd0000000797_model.tumor_growth_rate",
        "description": "Tumor Growth Rate. Sets bundled SBML parameter `r_1`."
      },
      {
        "name": "tumor_killing_cytokine_rate",
        "label": "Tumor Killing Cytokine Rate",
        "units": "native source value",
        "default": 0.2,
        "maps_to": "immunology_sbml_hu2018_dynamics_of_tumor_cd4_cytokine_host_cells_biomd0000000797_model.tumor_killing_cytokine_rate",
        "description": "Tumor Killing Cytokine Rate. Sets bundled SBML parameter `c_1`."
      },
      {
        "name": "cd4t_natural_death_rate",
        "label": "Cd4t Natural Death Rate",
        "units": "native source value",
        "default": 0.1,
        "maps_to": "immunology_sbml_hu2018_dynamics_of_tumor_cd4_cytokine_host_cells_biomd0000000797_model.cd4t_natural_death_rate",
        "description": "Cd4t Natural Death Rate. Sets bundled SBML parameter `mu_1`."
      },
      {
        "name": "cytokine_decay_rate",
        "label": "Cytokine Decay Rate",
        "units": "native source value",
        "default": 34,
        "maps_to": "immunology_sbml_hu2018_dynamics_of_tumor_cd4_cytokine_host_cells_biomd0000000797_model.cytokine_decay_rate",
        "description": "Cytokine Decay Rate. Sets bundled SBML parameter `mu_2`."
      },
      {
        "name": "normal_tissue_growth_rate",
        "label": "Normal Tissue Growth Rate",
        "units": "native source value",
        "default": 0.2822,
        "maps_to": "immunology_sbml_hu2018_dynamics_of_tumor_cd4_cytokine_host_cells_biomd0000000797_model.normal_tissue_growth_rate",
        "description": "Normal Tissue Growth Rate. Sets bundled SBML parameter `r_2`."
      }
    ],
    "outputs": [
      {
        "name": "tumor_cells",
        "maps_to": "immunology_sbml_hu2018_dynamics_of_tumor_cd4_cytokine_host_cells_biomd0000000797_model.tumor_cells"
      },
      {
        "name": "cd4_t_cells",
        "maps_to": "immunology_sbml_hu2018_dynamics_of_tumor_cd4_cytokine_host_cells_biomd0000000797_model.cd4_t_cells"
      },
      {
        "name": "cytokine",
        "maps_to": "immunology_sbml_hu2018_dynamics_of_tumor_cd4_cytokine_host_cells_biomd0000000797_model.cytokine"
      },
      {
        "name": "healthy_tissue",
        "maps_to": "immunology_sbml_hu2018_dynamics_of_tumor_cd4_cytokine_host_cells_biomd0000000797_model.healthy_tissue"
      },
      {
        "name": "state",
        "maps_to": "immunology_sbml_hu2018_dynamics_of_tumor_cd4_cytokine_host_cells_biomd0000000797_model.state"
      },
      {
        "name": "summary",
        "maps_to": "immunology_sbml_hu2018_dynamics_of_tumor_cd4_cytokine_host_cells_biomd0000000797_model.summary"
      },
      {
        "name": "species_labels",
        "maps_to": "immunology_sbml_hu2018_dynamics_of_tumor_cd4_cytokine_host_cells_biomd0000000797_model.species_labels"
      }
    ]
  },
  "title": "Hu2018 - Dynamics of tumor-CD4+-cytokine-host cells interactions with treatments Lab",
  "models": [
    {
      "path": "models/core",
      "alias": "immunology_sbml_hu2018_dynamics_of_tumor_cd4_cytokine_host_cells_biomd0000000797_model"
    },
    {
      "path": "models/visualisation",
      "alias": "visualisation"
    }
  ],
  "wiring": [
    {
      "to": [
        "visualisation.immunology_sbml_hu2018_dynamics_of_tumor_cd4_cytokine_host_cells_biomd0000000797_model_state"
      ],
      "from": "immunology_sbml_hu2018_dynamics_of_tumor_cd4_cytokine_host_cells_biomd0000000797_model.state"
    },
    {
      "to": [
        "visualisation.immunology_sbml_hu2018_dynamics_of_tumor_cd4_cytokine_host_cells_biomd0000000797_model_summary"
      ],
      "from": "immunology_sbml_hu2018_dynamics_of_tumor_cd4_cytokine_host_cells_biomd0000000797_model.summary"
    },
    {
      "to": [
        "visualisation.immunology_sbml_hu2018_dynamics_of_tumor_cd4_cytokine_host_cells_biomd0000000797_model_species_labels"
      ],
      "from": "immunology_sbml_hu2018_dynamics_of_tumor_cd4_cytokine_host_cells_biomd0000000797_model.species_labels"
    }
  ],
  "package": "hu2018-dynamics-of-tumor-cd4plus-cytokine-host-cells",
  "runtime": {
    "duration": 10,
    "initial_inputs": {},
    "communication_step": 1
  },
  "version": "1.0.0",
  "description": "This is a proposed mathematical model describing interactions between tumor cells, CD4+ T cells, cytokines, and host cells within the context of CD4+ T cells inducing tumor regression. It can be used to explore immune response dynamics and compare pathway-level behavior across conditions.",
  "schema_version": "2.0"
}