KaratzaKaralis2020 - CYP mediated losartan metabolism Lab

{
  "io": {
    "inputs": [
      {
        "name": "losartan_oral_dose",
        "label": "Losartan Oral Dose",
        "maps_to": "pharmacology_sbml_karatzakaralis2020_cyp_mediated_losartan_metabol_model2412180001_model.losartan_oral_dose"
      },
      {
        "name": "cyp2c9_metabolism_start_time",
        "label": "CYP2C9 Metabolism Start Time",
        "maps_to": "pharmacology_sbml_karatzakaralis2020_cyp_mediated_losartan_metabol_model2412180001_model.cyp2c9_metabolism_start_time"
      },
      {
        "name": "initial_losartan_stomach",
        "label": "Initial Losartan Stomach",
        "maps_to": "pharmacology_sbml_karatzakaralis2020_cyp_mediated_losartan_metabol_model2412180001_model.initial_losartan_stomach"
      }
    ],
    "outputs": [
      {
        "name": "state",
        "label": "Tracked source state",
        "maps_to": "pharmacology_sbml_karatzakaralis2020_cyp_mediated_losartan_metabol_model2412180001_model.state"
      },
      {
        "name": "summary",
        "label": "Simulation summary",
        "maps_to": "pharmacology_sbml_karatzakaralis2020_cyp_mediated_losartan_metabol_model2412180001_model.summary"
      },
      {
        "name": "species_labels",
        "label": "Observable labels",
        "maps_to": "pharmacology_sbml_karatzakaralis2020_cyp_mediated_losartan_metabol_model2412180001_model.species_labels"
      },
      {
        "name": "losartan_cellular_compartment",
        "label": "Losartan Cellular Compartment",
        "maps_to": "pharmacology_sbml_karatzakaralis2020_cyp_mediated_losartan_metabol_model2412180001_model.losartan_cellular_compartment"
      },
      {
        "name": "losartan_intracellular",
        "label": "Losartan Intracellular",
        "maps_to": "pharmacology_sbml_karatzakaralis2020_cyp_mediated_losartan_metabol_model2412180001_model.losartan_intracellular"
      },
      {
        "name": "losartan_outflow",
        "label": "Losartan Outflow",
        "maps_to": "pharmacology_sbml_karatzakaralis2020_cyp_mediated_losartan_metabol_model2412180001_model.losartan_outflow"
      },
      {
        "name": "losartan_portal_compartment",
        "label": "Losartan Portal Compartment",
        "maps_to": "pharmacology_sbml_karatzakaralis2020_cyp_mediated_losartan_metabol_model2412180001_model.losartan_portal_compartment"
      },
      {
        "name": "losartan_stomach",
        "label": "Losartan Stomach",
        "maps_to": "pharmacology_sbml_karatzakaralis2020_cyp_mediated_losartan_metabol_model2412180001_model.losartan_stomach"
      },
      {
        "name": "e3174_outflow",
        "label": "E3174 Outflow",
        "maps_to": "pharmacology_sbml_karatzakaralis2020_cyp_mediated_losartan_metabol_model2412180001_model.e3174_outflow"
      },
      {
        "name": "e3174_cellular_compartment",
        "label": "E3174 Cellular Compartment",
        "maps_to": "pharmacology_sbml_karatzakaralis2020_cyp_mediated_losartan_metabol_model2412180001_model.e3174_cellular_compartment"
      }
    ]
  },
  "tags": [
    "pharmacology",
    "metabolism",
    "cyp-metabolism",
    "pharmacokinetics",
    "cardiovascular",
    "sbml",
    "tellurium",
    "faithful",
    "biomodels_ebi"
  ],
  "title": "KaratzaKaralis2020 - CYP mediated losartan metabolism Lab",
  "models": [
    {
      "path": "owned/models/pharmacology_sbml_karatzakaralis2020_cyp_mediated_losartan_metabol_model2412180001_model",
      "alias": "pharmacology_sbml_karatzakaralis2020_cyp_mediated_losartan_metabol_model2412180001_model",
      "parameters": {
        "model_path": "data/MODEL2412180001.xml",
        "integration_step": 0.1
      },
      "provenance": {
        "owned_path": "owned/models/pharmacology_sbml_karatzakaralis2020_cyp_mediated_losartan_metabol_model2412180001_model"
      }
    },
    {
      "path": "owned/models/visualisation",
      "alias": "visualisation",
      "provenance": {
        "owned_path": "owned/models/visualisation"
      }
    }
  ],
  "wiring": [
    {
      "to": [
        "visualisation.pharmacology_sbml_karatzakaralis2020_cyp_mediated_losartan_metabol_model2412180001_model_state"
      ],
      "from": "pharmacology_sbml_karatzakaralis2020_cyp_mediated_losartan_metabol_model2412180001_model.state"
    },
    {
      "to": [
        "visualisation.pharmacology_sbml_karatzakaralis2020_cyp_mediated_losartan_metabol_model2412180001_model_summary"
      ],
      "from": "pharmacology_sbml_karatzakaralis2020_cyp_mediated_losartan_metabol_model2412180001_model.summary"
    },
    {
      "to": [
        "visualisation.pharmacology_sbml_karatzakaralis2020_cyp_mediated_losartan_metabol_model2412180001_model_species_labels"
      ],
      "from": "pharmacology_sbml_karatzakaralis2020_cyp_mediated_losartan_metabol_model2412180001_model.species_labels"
    }
  ],
  "runtime": {
    "duration": 24,
    "initial_inputs": {},
    "communication_step": 1
  },
  "description": "A four-compartment pharmacokinetic model that describes the disposition of losartan and E-3174 (Karatza and Karalis, 2020). The main objective of this model is to describe the secondary maxima observe.",
  "schema_version": "2.0"
}