Grange2001 - PK interaction of L-dopa and benserazide Lab

{
  "io": {
    "inputs": [
      {
        "name": "l_dopa_dose_per_kg_rat",
        "label": "L Dopa Dose Per Kg Rat",
        "maps_to": "pharmacology_sbml_grange2001_pk_interaction_of_l_dopa_and_benseraz_biomd0000000320_model.l_dopa_dose_per_kg_rat"
      },
      {
        "name": "benserazide_dose_per_kg_rat",
        "label": "Benserazide Dose Per Kg Rat",
        "maps_to": "pharmacology_sbml_grange2001_pk_interaction_of_l_dopa_and_benseraz_biomd0000000320_model.benserazide_dose_per_kg_rat"
      },
      {
        "name": "l_dopa_clearance_rate",
        "label": "L Dopa Clearance Rate",
        "maps_to": "pharmacology_sbml_grange2001_pk_interaction_of_l_dopa_and_benseraz_biomd0000000320_model.l_dopa_clearance_rate"
      },
      {
        "name": "benserazide_clearance_rate",
        "label": "Benserazide Clearance Rate",
        "maps_to": "pharmacology_sbml_grange2001_pk_interaction_of_l_dopa_and_benseraz_biomd0000000320_model.benserazide_clearance_rate"
      }
    ],
    "outputs": [
      {
        "name": "state",
        "label": "Tracked source state",
        "maps_to": "pharmacology_sbml_grange2001_pk_interaction_of_l_dopa_and_benseraz_biomd0000000320_model.state"
      },
      {
        "name": "summary",
        "label": "Simulation summary",
        "maps_to": "pharmacology_sbml_grange2001_pk_interaction_of_l_dopa_and_benseraz_biomd0000000320_model.summary"
      },
      {
        "name": "species_labels",
        "label": "Observable labels",
        "maps_to": "pharmacology_sbml_grange2001_pk_interaction_of_l_dopa_and_benseraz_biomd0000000320_model.species_labels"
      },
      {
        "name": "l_dopa_amount",
        "label": "L Dopa Amount",
        "maps_to": "pharmacology_sbml_grange2001_pk_interaction_of_l_dopa_and_benseraz_biomd0000000320_model.l_dopa_amount"
      },
      {
        "name": "l_dopa_concentration",
        "label": "L Dopa Concentration",
        "maps_to": "pharmacology_sbml_grange2001_pk_interaction_of_l_dopa_and_benseraz_biomd0000000320_model.l_dopa_concentration"
      },
      {
        "name": "benserazide_amount",
        "label": "Benserazide Amount",
        "maps_to": "pharmacology_sbml_grange2001_pk_interaction_of_l_dopa_and_benseraz_biomd0000000320_model.benserazide_amount"
      },
      {
        "name": "metabolite_amount",
        "label": "Metabolite Amount",
        "maps_to": "pharmacology_sbml_grange2001_pk_interaction_of_l_dopa_and_benseraz_biomd0000000320_model.metabolite_amount"
      },
      {
        "name": "three_omd_concentration",
        "label": "Three Omd Concentration",
        "maps_to": "pharmacology_sbml_grange2001_pk_interaction_of_l_dopa_and_benseraz_biomd0000000320_model.three_omd_concentration"
      },
      {
        "name": "metabolite_compartment_1_concentration",
        "label": "Metabolite Compartment 1 Concentration",
        "maps_to": "pharmacology_sbml_grange2001_pk_interaction_of_l_dopa_and_benseraz_biomd0000000320_model.metabolite_compartment_1_concentration"
      },
      {
        "name": "benserazide_compartment_1_concentration",
        "label": "Benserazide Compartment 1 Concentration",
        "maps_to": "pharmacology_sbml_grange2001_pk_interaction_of_l_dopa_and_benseraz_biomd0000000320_model.benserazide_compartment_1_concentration"
      }
    ]
  },
  "tags": [
    "pharmacology",
    "pharmacokinetics",
    "drug-interaction",
    "neuroscience",
    "sbml",
    "tellurium",
    "faithful",
    "biomodels_ebi"
  ],
  "title": "Grange2001 - PK interaction of L-dopa and benserazide Lab",
  "models": [
    {
      "path": "owned/models/pharmacology_sbml_grange2001_pk_interaction_of_l_dopa_and_benseraz_biomd0000000320_model",
      "alias": "pharmacology_sbml_grange2001_pk_interaction_of_l_dopa_and_benseraz_biomd0000000320_model",
      "parameters": {
        "model_path": "data/BIOMD0000000320.xml",
        "integration_step": 0.1
      },
      "provenance": {
        "owned_path": "owned/models/pharmacology_sbml_grange2001_pk_interaction_of_l_dopa_and_benseraz_biomd0000000320_model"
      }
    },
    {
      "path": "owned/models/visualisation",
      "alias": "visualisation",
      "provenance": {
        "owned_path": "owned/models/visualisation"
      }
    }
  ],
  "wiring": [
    {
      "to": [
        "visualisation.pharmacology_sbml_grange2001_pk_interaction_of_l_dopa_and_benseraz_biomd0000000320_model_state"
      ],
      "from": "pharmacology_sbml_grange2001_pk_interaction_of_l_dopa_and_benseraz_biomd0000000320_model.state"
    },
    {
      "to": [
        "visualisation.pharmacology_sbml_grange2001_pk_interaction_of_l_dopa_and_benseraz_biomd0000000320_model_summary"
      ],
      "from": "pharmacology_sbml_grange2001_pk_interaction_of_l_dopa_and_benseraz_biomd0000000320_model.summary"
    },
    {
      "to": [
        "visualisation.pharmacology_sbml_grange2001_pk_interaction_of_l_dopa_and_benseraz_biomd0000000320_model_species_labels"
      ],
      "from": "pharmacology_sbml_grange2001_pk_interaction_of_l_dopa_and_benseraz_biomd0000000320_model.species_labels"
    }
  ],
  "runtime": {
    "duration": 24,
    "initial_inputs": {},
    "communication_step": 1
  },
  "description": "Grange2001 - PK interaction of L-dopa and benserazide A pharmacokinetics of L-dopa in rats after administration of L-dopa alone (BIOMD0000000321) or L-dopa combined with a peripheral AADC (amino-acid-. It can be used to explore dose-response dynamics and compare treatment scenarios across conditions.",
  "schema_version": "2.0"
}