Dorvash2019 - Dynamic modeling of signal transduction by mTOR complexes in cancer Lab

{
  "io": {
    "inputs": [
      {
        "name": "rapamycin_dose_source_parameter",
        "label": "Rapamycin Dose source parameter",
        "units": "native SBML value",
        "default": 0,
        "maps_to": "oncology_sbml_dorvash2019_dynamic_modeling_of_signal_transduct_biomd0000000822_model.rapamycin_dose_source_parameter",
        "description": "Rapamycin Dose source parameter. Maps to bundled SBML parameter `Rapamycin_Dose`."
      },
      {
        "name": "initial_mtor",
        "label": "MTOR",
        "units": "native SBML value",
        "default": 3.756228e-7,
        "maps_to": "oncology_sbml_dorvash2019_dynamic_modeling_of_signal_transduct_biomd0000000822_model.initial_mtor",
        "description": "Initial MTOR. Sets the initial value of bundled SBML symbol `mTOR`."
      },
      {
        "name": "initial_raptor",
        "label": "Raptor",
        "units": "native SBML value",
        "default": 3.201594e-7,
        "maps_to": "oncology_sbml_dorvash2019_dynamic_modeling_of_signal_transduct_biomd0000000822_model.initial_raptor",
        "description": "Initial Raptor. Sets the initial value of bundled SBML symbol `Raptor`."
      },
      {
        "name": "initial_rictor",
        "label": "Rictor",
        "units": "native SBML value",
        "default": 8.834274e-8,
        "maps_to": "oncology_sbml_dorvash2019_dynamic_modeling_of_signal_transduct_biomd0000000822_model.initial_rictor",
        "description": "Initial Rictor. Sets the initial value of bundled SBML symbol `Rictor`."
      },
      {
        "name": "initial_cytosolic_rapamycin",
        "label": "Cytosolic Rapamycin",
        "units": "native SBML value",
        "default": 0,
        "maps_to": "oncology_sbml_dorvash2019_dynamic_modeling_of_signal_transduct_biomd0000000822_model.initial_cytosolic_rapamycin",
        "description": "Initial Cytosolic Rapamycin. Sets the initial value of bundled SBML symbol `Cytosolic_Rapamycin`."
      },
      {
        "name": "initial_mtorc1",
        "label": "MTORC1",
        "units": "native SBML value",
        "default": 0,
        "maps_to": "oncology_sbml_dorvash2019_dynamic_modeling_of_signal_transduct_biomd0000000822_model.initial_mtorc1",
        "description": "Initial MTORC1. Sets the initial value of bundled SBML symbol `mTORC1`."
      }
    ],
    "outputs": [
      {
        "name": "mtor",
        "maps_to": "oncology_sbml_dorvash2019_dynamic_modeling_of_signal_transduct_biomd0000000822_model.mtor",
        "description": "MTOR observable. Maps to SBML symbol `mTOR`."
      },
      {
        "name": "raptor",
        "maps_to": "oncology_sbml_dorvash2019_dynamic_modeling_of_signal_transduct_biomd0000000822_model.raptor",
        "description": "Raptor observable. Maps to SBML symbol `Raptor`."
      },
      {
        "name": "rictor",
        "maps_to": "oncology_sbml_dorvash2019_dynamic_modeling_of_signal_transduct_biomd0000000822_model.rictor",
        "description": "Rictor observable. Maps to SBML symbol `Rictor`."
      },
      {
        "name": "cytosolic_rapamycin",
        "maps_to": "oncology_sbml_dorvash2019_dynamic_modeling_of_signal_transduct_biomd0000000822_model.cytosolic_rapamycin",
        "description": "Cytosolic Rapamycin observable. Maps to SBML symbol `Cytosolic_Rapamycin`."
      },
      {
        "name": "mtorc1",
        "maps_to": "oncology_sbml_dorvash2019_dynamic_modeling_of_signal_transduct_biomd0000000822_model.mtorc1",
        "description": "MTORC1 observable. Maps to SBML symbol `mTORC1`."
      },
      {
        "name": "mtorc2",
        "maps_to": "oncology_sbml_dorvash2019_dynamic_modeling_of_signal_transduct_biomd0000000822_model.mtorc2",
        "description": "MTORC2 observable. Maps to SBML symbol `mTORC2`."
      },
      {
        "name": "state",
        "maps_to": "oncology_sbml_dorvash2019_dynamic_modeling_of_signal_transduct_biomd0000000822_model.state",
        "description": "Full raw SBML observable record for reproducibility and downstream visualisation."
      },
      {
        "name": "summary",
        "maps_to": "oncology_sbml_dorvash2019_dynamic_modeling_of_signal_transduct_biomd0000000822_model.summary",
        "description": "Change and peak summary across the simulated SBML observables."
      },
      {
        "name": "species_labels",
        "maps_to": "oncology_sbml_dorvash2019_dynamic_modeling_of_signal_transduct_biomd0000000822_model.species_labels",
        "description": "Mapping from selected raw SBML observable symbols to display labels."
      }
    ]
  },
  "tags": [
    "biomodels_ebi",
    "curated",
    "drug-response",
    "faithful",
    "oncology",
    "pharmacology",
    "physiology",
    "sbml",
    "signal-transduction",
    "signaling",
    "systemsbiology",
    "tumor-growth"
  ],
  "title": "Dorvash2019 - Dynamic modeling of signal transduction by mTOR complexes in cancer Lab",
  "models": [
    {
      "path": "owned/models/oncology_sbml_dorvash2019_dynamic_modeling_of_signal_transduct_biomd0000000822_model",
      "alias": "oncology_sbml_dorvash2019_dynamic_modeling_of_signal_transduct_biomd0000000822_model",
      "provenance": {
        "owned_path": "owned/models/oncology_sbml_dorvash2019_dynamic_modeling_of_signal_transduct_biomd0000000822_model"
      }
    },
    {
      "path": "owned/models/visualisation",
      "alias": "visualisation",
      "provenance": {
        "owned_path": "owned/models/visualisation"
      }
    }
  ],
  "wiring": [
    {
      "to": [
        "visualisation.oncology_sbml_dorvash2019_dynamic_modeling_of_signal_transduct_biomd0000000822_model_state"
      ],
      "from": "oncology_sbml_dorvash2019_dynamic_modeling_of_signal_transduct_biomd0000000822_model.state"
    },
    {
      "to": [
        "visualisation.oncology_sbml_dorvash2019_dynamic_modeling_of_signal_transduct_biomd0000000822_model_summary"
      ],
      "from": "oncology_sbml_dorvash2019_dynamic_modeling_of_signal_transduct_biomd0000000822_model.summary"
    },
    {
      "to": [
        "visualisation.oncology_sbml_dorvash2019_dynamic_modeling_of_signal_transduct_biomd0000000822_model_species_labels"
      ],
      "from": "oncology_sbml_dorvash2019_dynamic_modeling_of_signal_transduct_biomd0000000822_model.species_labels"
    }
  ],
  "runtime": {
    "duration": 10,
    "initial_inputs": {},
    "communication_step": 1
  },
  "description": "This model is based on:Dynamic modeling of signal transduction by mTOR complexes in cancerAuthor:Mohammadreza Dorvash, Mohammad Farahmandnia, Pouria Mosaddeghi, Mitra Farahmandnejad, Hosein Saber, Moh. It can be used to explore tumor-related dynamics and compare treatment-response behavior across conditions.",
  "schema_version": "2.0"
}