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Sontag2017 - Dynamic model of immune responses to antigen presentation by tumor or pathogen Lab

About lab

This model of the immune system response to antigen presentation is based on the publication:Eduardo D.Sontag (2017) 'A Dynamic Model of Immune Responses to Antigen Presentation Predicts Different Reg. It can be used to explore immune response dynamics and compare pathway-level behavior across conditions.

Runtime

Duration10
Comms Step1

Runs

Total0
Completed0
Failed0

Metadata

Packagesontag2017-dynamic-model-of-immune-responses-to-antigen-presenta
Created2026-05-15
Updated2026-05-15
immunologysbmlbiomodels_ebifaithfulcuratedvisualisation

Manifest

{
  "io": {
    "inputs": [
      {
        "name": "initial_regulatory_cells",
        "label": "Initial Regulatory Cells",
        "units": "native source value",
        "default": 1,
        "maps_to": "immunology_sbml_sontag2017_dynamic_model_of_immune_responses_to_biomd0000001030_model.initial_regulatory_cells",
        "description": "Initial Regulatory Cells. Sets the initial value of bundled SBML species `Regulatory_cells`."
      },
      {
        "name": "initial_effector_cells",
        "label": "Initial Effector Cells",
        "units": "native source value",
        "default": 1,
        "maps_to": "immunology_sbml_sontag2017_dynamic_model_of_immune_responses_to_biomd0000001030_model.initial_effector_cells",
        "description": "Initial Effector Cells. Sets the initial value of bundled SBML species `Effector_cells`."
      }
    ],
    "outputs": [
      {
        "name": "antigen_expressing_cells",
        "maps_to": "immunology_sbml_sontag2017_dynamic_model_of_immune_responses_to_biomd0000001030_model.antigen_expressing_cells"
      },
      {
        "name": "regulatory_cells",
        "maps_to": "immunology_sbml_sontag2017_dynamic_model_of_immune_responses_to_biomd0000001030_model.regulatory_cells"
      },
      {
        "name": "effector_cells",
        "maps_to": "immunology_sbml_sontag2017_dynamic_model_of_immune_responses_to_biomd0000001030_model.effector_cells"
      },
      {
        "name": "state",
        "maps_to": "immunology_sbml_sontag2017_dynamic_model_of_immune_responses_to_biomd0000001030_model.state"
      },
      {
        "name": "summary",
        "maps_to": "immunology_sbml_sontag2017_dynamic_model_of_immune_responses_to_biomd0000001030_model.summary"
      },
      {
        "name": "species_labels",
        "maps_to": "immunology_sbml_sontag2017_dynamic_model_of_immune_responses_to_biomd0000001030_model.species_labels"
      }
    ]
  },
  "title": "Sontag2017 - Dynamic model of immune responses to antigen presentation by tumor or pathogen Lab",
  "models": [
    {
      "path": "owned/models/immunology_sbml_sontag2017_dynamic_model_of_immune_responses_to_biomd0000001030_model",
      "alias": "immunology_sbml_sontag2017_dynamic_model_of_immune_responses_to_biomd0000001030_model",
      "provenance": {
        "owned_path": "owned/models/immunology_sbml_sontag2017_dynamic_model_of_immune_responses_to_biomd0000001030_model"
      }
    },
    {
      "path": "owned/models/visualisation",
      "alias": "visualisation",
      "provenance": {
        "owned_path": "owned/models/visualisation"
      }
    }
  ],
  "wiring": [
    {
      "to": [
        "visualisation.immunology_sbml_sontag2017_dynamic_model_of_immune_responses_to_biomd0000001030_model_state"
      ],
      "from": "immunology_sbml_sontag2017_dynamic_model_of_immune_responses_to_biomd0000001030_model.state"
    },
    {
      "to": [
        "visualisation.immunology_sbml_sontag2017_dynamic_model_of_immune_responses_to_biomd0000001030_model_summary"
      ],
      "from": "immunology_sbml_sontag2017_dynamic_model_of_immune_responses_to_biomd0000001030_model.summary"
    },
    {
      "to": [
        "visualisation.immunology_sbml_sontag2017_dynamic_model_of_immune_responses_to_biomd0000001030_model_species_labels"
      ],
      "from": "immunology_sbml_sontag2017_dynamic_model_of_immune_responses_to_biomd0000001030_model.species_labels"
    }
  ],
  "runtime": {
    "duration": 10,
    "initial_inputs": {},
    "communication_step": 1
  },
  "description": "This model of the immune system response to antigen presentation is based on the publication:Eduardo D.Sontag (2017) 'A Dynamic Model of Immune Responses to Antigen Presentation Predicts Different Reg. It can be used to explore immune response dynamics and compare pathway-level behavior across conditions.",
  "schema_version": "2.0"
}

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