{
  "io": {
    "inputs": [
      {
        "name": "initial_b_glycine",
        "units": "native SBML value",
        "default": 218.733171504338,
        "maps_to": "metabolism_sbml_reyes_palomares2012_a_combined_model_hepatic_pol_biomd0000000674_model.initial_b_glycine",
        "description": "Initial condition for b glycine. Maps to bundled SBML symbol `b_gly`. Applied before the Tellurium simulation starts; this does not change kinetic parameters or equations. Default from bundled SBML initial value."
      },
      {
        "name": "initial_b_glutamate",
        "units": "native SBML value",
        "default": 60.4651616225031,
        "maps_to": "metabolism_sbml_reyes_palomares2012_a_combined_model_hepatic_pol_biomd0000000674_model.initial_b_glutamate",
        "description": "Initial condition for b glutamate. Maps to bundled SBML symbol `b_glu`. Applied before the Tellurium simulation starts; this does not change kinetic parameters or equations. Default from bundled SBML initial value."
      },
      {
        "name": "initial_b_cysteine",
        "units": "native SBML value",
        "default": 183.099466381356,
        "maps_to": "metabolism_sbml_reyes_palomares2012_a_combined_model_hepatic_pol_biomd0000000674_model.initial_b_cysteine",
        "description": "Initial condition for b cysteine. Maps to bundled SBML symbol `b_cys`. Applied before the Tellurium simulation starts; this does not change kinetic parameters or equations. Default from bundled SBML initial value."
      },
      {
        "name": "initial_metabolic_pathway_state_4",
        "units": "native SBML value",
        "default": 0.472632922783833,
        "maps_to": "metabolism_sbml_reyes_palomares2012_a_combined_model_hepatic_pol_biomd0000000674_model.initial_metabolic_pathway_state_4",
        "description": "Initial condition for metabolic pathway state 4. Maps to bundled SBML symbol `b_gsg`. Applied before the Tellurium simulation starts; this does not change kinetic parameters or equations. Default from bundled SBML initial value."
      },
      {
        "name": "initial_blood_glutathione",
        "units": "native SBML value",
        "default": 12.5470655822207,
        "maps_to": "metabolism_sbml_reyes_palomares2012_a_combined_model_hepatic_pol_biomd0000000674_model.initial_blood_glutathione",
        "description": "Initial condition for blood glutathione. Maps to bundled SBML symbol `b_gsh`. Applied before the Tellurium simulation starts; this does not change kinetic parameters or equations. Default from bundled SBML initial value."
      }
    ],
    "outputs": [
      {
        "name": "b_glycine",
        "maps_to": "metabolism_sbml_reyes_palomares2012_a_combined_model_hepatic_pol_biomd0000000674_model.b_glycine"
      },
      {
        "name": "b_glutamate",
        "maps_to": "metabolism_sbml_reyes_palomares2012_a_combined_model_hepatic_pol_biomd0000000674_model.b_glutamate"
      },
      {
        "name": "b_cysteine",
        "maps_to": "metabolism_sbml_reyes_palomares2012_a_combined_model_hepatic_pol_biomd0000000674_model.b_cysteine"
      },
      {
        "name": "metabolic_pathway_state_4",
        "maps_to": "metabolism_sbml_reyes_palomares2012_a_combined_model_hepatic_pol_biomd0000000674_model.metabolic_pathway_state_4"
      },
      {
        "name": "blood_glutathione",
        "maps_to": "metabolism_sbml_reyes_palomares2012_a_combined_model_hepatic_pol_biomd0000000674_model.blood_glutathione"
      },
      {
        "name": "observable_values",
        "maps_to": "metabolism_sbml_reyes_palomares2012_a_combined_model_hepatic_pol_biomd0000000674_model.observable_values"
      },
      {
        "name": "run_summary",
        "maps_to": "metabolism_sbml_reyes_palomares2012_a_combined_model_hepatic_pol_biomd0000000674_model.run_summary"
      },
      {
        "name": "observable_labels",
        "maps_to": "metabolism_sbml_reyes_palomares2012_a_combined_model_hepatic_pol_biomd0000000674_model.observable_labels"
      }
    ]
  },
  "title": "Reyes-Palomares2012 - a combined model hepatic polyamine and sulfur aminoacid metabolism - version1 Lab",
  "models": [
    {
      "path": "owned/models/metabolism_sbml_reyes_palomares2012_a_combined_model_hepatic_pol_biomd0000000674_model",
      "alias": "metabolism_sbml_reyes_palomares2012_a_combined_model_hepatic_pol_biomd0000000674_model",
      "parameters": {
        "model_path": "data/BIOMD0000000674.xml",
        "integration_step": 0.1
      },
      "provenance": {
        "owned_path": "owned/models/metabolism_sbml_reyes_palomares2012_a_combined_model_hepatic_pol_biomd0000000674_model"
      }
    },
    {
      "path": "owned/models/visualisation",
      "alias": "visualisation",
      "provenance": {
        "owned_path": "owned/models/visualisation"
      }
    }
  ],
  "wiring": [
    {
      "to": [
        "visualisation.metabolism_sbml_reyes_palomares2012_a_combined_model_hepatic_pol_biomd0000000674_model_observable_values"
      ],
      "from": "metabolism_sbml_reyes_palomares2012_a_combined_model_hepatic_pol_biomd0000000674_model.observable_values"
    },
    {
      "to": [
        "visualisation.metabolism_sbml_reyes_palomares2012_a_combined_model_hepatic_pol_biomd0000000674_model_run_summary"
      ],
      "from": "metabolism_sbml_reyes_palomares2012_a_combined_model_hepatic_pol_biomd0000000674_model.run_summary"
    },
    {
      "to": [
        "visualisation.metabolism_sbml_reyes_palomares2012_a_combined_model_hepatic_pol_biomd0000000674_model_observable_labels"
      ],
      "from": "metabolism_sbml_reyes_palomares2012_a_combined_model_hepatic_pol_biomd0000000674_model.observable_labels"
    }
  ],
  "runtime": {
    "duration": 10,
    "initial_inputs": {},
    "communication_step": 1
  },
  "description": "Reyes-Palomares2012 - a combined modelhepatic polyamine and sulfur aminoacid metabolism - version1 Mammalian polyamine metabolism consists of a bi-cycle with two required entrances, omithine and S-ade. It can be used to explore metabolic flux dynamics and compare pathway behavior across conditions.",
  "schema_version": "2.0"
}