Strasen2018 - TGFb SMAD Signalling - Dose dependent dynamics upon TGFb stimulation Lab

{
  "io": {
    "inputs": [
      {
        "name": "tgfb_ligand_dose",
        "label": "TGFB Ligand Dose",
        "maps_to": "pharmacology_sbml_strasen2018_tgfb_smad_signalling_dose_dependent_biomd0000000989_model.tgfb_ligand_dose"
      },
      {
        "name": "initial_surface_tgf_beta_receptor_1",
        "label": "Initial Surface TGF Beta Receptor 1",
        "maps_to": "pharmacology_sbml_strasen2018_tgfb_smad_signalling_dose_dependent_biomd0000000989_model.initial_surface_tgf_beta_receptor_1"
      },
      {
        "name": "initial_surface_tgf_beta_receptor_2",
        "label": "Initial Surface TGF Beta Receptor 2",
        "maps_to": "pharmacology_sbml_strasen2018_tgfb_smad_signalling_dose_dependent_biomd0000000989_model.initial_surface_tgf_beta_receptor_2"
      },
      {
        "name": "receptor_phosphorylation_rate",
        "label": "Receptor Phosphorylation Rate",
        "maps_to": "pharmacology_sbml_strasen2018_tgfb_smad_signalling_dose_dependent_biomd0000000989_model.receptor_phosphorylation_rate"
      },
      {
        "name": "ligand_degradation_rate",
        "label": "Ligand Degradation Rate",
        "maps_to": "pharmacology_sbml_strasen2018_tgfb_smad_signalling_dose_dependent_biomd0000000989_model.ligand_degradation_rate"
      }
    ],
    "outputs": [
      {
        "name": "state",
        "label": "Tracked source state",
        "maps_to": "pharmacology_sbml_strasen2018_tgfb_smad_signalling_dose_dependent_biomd0000000989_model.state"
      },
      {
        "name": "summary",
        "label": "Simulation summary",
        "maps_to": "pharmacology_sbml_strasen2018_tgfb_smad_signalling_dose_dependent_biomd0000000989_model.summary"
      },
      {
        "name": "species_labels",
        "label": "Observable labels",
        "maps_to": "pharmacology_sbml_strasen2018_tgfb_smad_signalling_dose_dependent_biomd0000000989_model.species_labels"
      },
      {
        "name": "surface_tgf_beta_receptor_1",
        "label": "Surface TGF Beta Receptor 1",
        "maps_to": "pharmacology_sbml_strasen2018_tgfb_smad_signalling_dose_dependent_biomd0000000989_model.surface_tgf_beta_receptor_1"
      },
      {
        "name": "surface_tgf_beta_receptor_2",
        "label": "Surface TGF Beta Receptor 2",
        "maps_to": "pharmacology_sbml_strasen2018_tgfb_smad_signalling_dose_dependent_biomd0000000989_model.surface_tgf_beta_receptor_2"
      },
      {
        "name": "endosomal_tgf_beta_receptor_1",
        "label": "Endosomal TGF Beta Receptor 1",
        "maps_to": "pharmacology_sbml_strasen2018_tgfb_smad_signalling_dose_dependent_biomd0000000989_model.endosomal_tgf_beta_receptor_1"
      },
      {
        "name": "endosomal_tgf_beta_receptor_2",
        "label": "Endosomal TGF Beta Receptor 2",
        "maps_to": "pharmacology_sbml_strasen2018_tgfb_smad_signalling_dose_dependent_biomd0000000989_model.endosomal_tgf_beta_receptor_2"
      },
      {
        "name": "tgf_beta_ligand",
        "label": "TGF Beta Ligand",
        "maps_to": "pharmacology_sbml_strasen2018_tgfb_smad_signalling_dose_dependent_biomd0000000989_model.tgf_beta_ligand"
      },
      {
        "name": "internalized_tgf_beta",
        "label": "Internalized TGF Beta",
        "maps_to": "pharmacology_sbml_strasen2018_tgfb_smad_signalling_dose_dependent_biomd0000000989_model.internalized_tgf_beta"
      },
      {
        "name": "active_receptor_2",
        "label": "Active Receptor 2",
        "maps_to": "pharmacology_sbml_strasen2018_tgfb_smad_signalling_dose_dependent_biomd0000000989_model.active_receptor_2"
      },
      {
        "name": "active_tgf_beta_receptor_complex",
        "label": "Active TGF Beta Receptor Complex",
        "maps_to": "pharmacology_sbml_strasen2018_tgfb_smad_signalling_dose_dependent_biomd0000000989_model.active_tgf_beta_receptor_complex"
      }
    ]
  },
  "tags": [
    "pharmacology",
    "signaling",
    "oncology",
    "dose-response",
    "sbml",
    "tellurium",
    "faithful",
    "biomodels_ebi"
  ],
  "title": "Strasen2018 - TGFb SMAD Signalling - Dose dependent dynamics upon TGFb stimulation Lab",
  "models": [
    {
      "path": "models/core",
      "alias": "pharmacology_sbml_strasen2018_tgfb_smad_signalling_dose_dependent_biomd0000000989_model",
      "parameters": {
        "model_path": "data/BIOMD0000000989.xml",
        "integration_step": 0.2
      }
    },
    {
      "path": "models/visualisation",
      "alias": "visualisation"
    }
  ],
  "wiring": [
    {
      "to": [
        "visualisation.pharmacology_sbml_strasen2018_tgfb_smad_signalling_dose_dependent_biomd0000000989_model_state"
      ],
      "from": "pharmacology_sbml_strasen2018_tgfb_smad_signalling_dose_dependent_biomd0000000989_model.state"
    },
    {
      "to": [
        "visualisation.pharmacology_sbml_strasen2018_tgfb_smad_signalling_dose_dependent_biomd0000000989_model_summary"
      ],
      "from": "pharmacology_sbml_strasen2018_tgfb_smad_signalling_dose_dependent_biomd0000000989_model.summary"
    },
    {
      "to": [
        "visualisation.pharmacology_sbml_strasen2018_tgfb_smad_signalling_dose_dependent_biomd0000000989_model_species_labels"
      ],
      "from": "pharmacology_sbml_strasen2018_tgfb_smad_signalling_dose_dependent_biomd0000000989_model.species_labels"
    }
  ],
  "package": "strasen2018-tgfb-smad-dose-response",
  "runtime": {
    "duration": 60,
    "initial_inputs": {},
    "communication_step": 2
  },
  "version": "1.0.0",
  "description": "This model simulates TGFb dose dependent kinetics of The SMADs. TGFb ligand dose applied are 1pM, 2.5pM, 5pM, 25pM, and 100pM as explained in the manuscript.",
  "schema_version": "2.0"
}