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Andersen2017 - Mathematical modelling as a proof of concept for MPNs as a human inflammation model for cancer development Lab

About lab

This is a mathematical model investigating the role of chronic inflammation in the development and progression of myeloproliferative neoplasms (MPNs). The model describes the proliferation from stem c.

Runtime

Duration10
Comms Step1

Runs

Total0
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Metadata

Packageandersen2017-mathematical-modelling-as-a-proof-of-concept-for-mp
Created2026-05-16
Updated2026-05-16
biomodels_ebicuratedfaithfuloncologyphysiologysbmlsystemsbiologytumor-growthvisualisation

Manifest

{
  "io": {
    "inputs": [
      {
        "name": "inflammation_level",
        "label": "Inflammation Level",
        "units": "native SBML value",
        "default": 7,
        "maps_to": "oncology_sbml_andersen2017_mathematical_modelling_as_a_proof_o_biomd0000000852_model.inflammation_level",
        "description": "Inflammation Level. Overrides bundled SBML parameter `inflammation`."
      }
    ],
    "outputs": [
      {
        "name": "x0",
        "maps_to": "oncology_sbml_andersen2017_mathematical_modelling_as_a_proof_o_biomd0000000852_model.x0",
        "description": "X0 observable. Maps to SBML symbol `x0`."
      },
      {
        "name": "x1",
        "maps_to": "oncology_sbml_andersen2017_mathematical_modelling_as_a_proof_o_biomd0000000852_model.x1",
        "description": "X1 observable. Maps to SBML symbol `x1`."
      },
      {
        "name": "a",
        "maps_to": "oncology_sbml_andersen2017_mathematical_modelling_as_a_proof_o_biomd0000000852_model.a",
        "description": "A observable. Maps to SBML symbol `a`."
      },
      {
        "name": "s",
        "maps_to": "oncology_sbml_andersen2017_mathematical_modelling_as_a_proof_o_biomd0000000852_model.s",
        "description": "S observable. Maps to SBML symbol `s`."
      },
      {
        "name": "y0",
        "maps_to": "oncology_sbml_andersen2017_mathematical_modelling_as_a_proof_o_biomd0000000852_model.y0",
        "description": "Y0 observable. Maps to SBML symbol `y0`."
      },
      {
        "name": "y1",
        "maps_to": "oncology_sbml_andersen2017_mathematical_modelling_as_a_proof_o_biomd0000000852_model.y1",
        "description": "Y1 observable. Maps to SBML symbol `y1`."
      },
      {
        "name": "state",
        "maps_to": "oncology_sbml_andersen2017_mathematical_modelling_as_a_proof_o_biomd0000000852_model.state",
        "description": "Full raw SBML observable record for reproducibility and downstream visualisation."
      },
      {
        "name": "summary",
        "maps_to": "oncology_sbml_andersen2017_mathematical_modelling_as_a_proof_o_biomd0000000852_model.summary",
        "description": "Change and peak summary across the simulated SBML observables."
      },
      {
        "name": "species_labels",
        "maps_to": "oncology_sbml_andersen2017_mathematical_modelling_as_a_proof_o_biomd0000000852_model.species_labels",
        "description": "Mapping from selected raw SBML observable symbols to display labels."
      }
    ]
  },
  "tags": [
    "biomodels_ebi",
    "curated",
    "faithful",
    "oncology",
    "physiology",
    "sbml",
    "systemsbiology",
    "tumor-growth"
  ],
  "title": "Andersen2017 - Mathematical modelling as a proof of concept for MPNs as a human inflammation model for cancer development Lab",
  "models": [
    {
      "path": "owned/models/oncology_sbml_andersen2017_mathematical_modelling_as_a_proof_o_biomd0000000852_model",
      "alias": "oncology_sbml_andersen2017_mathematical_modelling_as_a_proof_o_biomd0000000852_model",
      "provenance": {
        "owned_path": "owned/models/oncology_sbml_andersen2017_mathematical_modelling_as_a_proof_o_biomd0000000852_model"
      }
    },
    {
      "path": "owned/models/visualisation",
      "alias": "visualisation",
      "provenance": {
        "owned_path": "owned/models/visualisation"
      }
    }
  ],
  "wiring": [
    {
      "to": [
        "visualisation.oncology_sbml_andersen2017_mathematical_modelling_as_a_proof_o_biomd0000000852_model_state"
      ],
      "from": "oncology_sbml_andersen2017_mathematical_modelling_as_a_proof_o_biomd0000000852_model.state"
    },
    {
      "to": [
        "visualisation.oncology_sbml_andersen2017_mathematical_modelling_as_a_proof_o_biomd0000000852_model_summary"
      ],
      "from": "oncology_sbml_andersen2017_mathematical_modelling_as_a_proof_o_biomd0000000852_model.summary"
    },
    {
      "to": [
        "visualisation.oncology_sbml_andersen2017_mathematical_modelling_as_a_proof_o_biomd0000000852_model_species_labels"
      ],
      "from": "oncology_sbml_andersen2017_mathematical_modelling_as_a_proof_o_biomd0000000852_model.species_labels"
    }
  ],
  "runtime": {
    "duration": 10,
    "initial_inputs": {},
    "communication_step": 1
  },
  "description": "This is a mathematical model investigating the role of chronic inflammation in the development and progression of myeloproliferative neoplasms (MPNs). The model describes the proliferation from stem c.",
  "schema_version": "2.0"
}

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