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Aavani2019 - The role of CD4 T cells in immune system activation and viral reproduction in a simple model for HIV infection Lab

About lab

This is a mathematical model comprised of a simple system of four ordinary differential equations that account for the two opposing roles of infected and healthy cytotoxic T lymphocytes within the con. It can be used to explore immune response dynamics and compare pathway-level behavior across conditions.

Runtime

Duration10
Comms Step1

Runs

Total0
Completed0
Failed0

Metadata

Packageaavani2019-the-role-of-cd4-t-cells-in-immune-system-activation-a
Created2026-05-15
Updated2026-05-15
immunologysbmlbiomodels_ebifaithfulcuratedvisualisation

Manifest

{
  "io": {
    "inputs": [
      {
        "name": "initial_uninfected_cd4_t_cells",
        "label": "Initial Uninfected CD4 T Cells",
        "units": "native source value",
        "default": 1000,
        "maps_to": "immunology_sbml_aavani2019_the_role_of_cd4_t_cells_in_immune_sys_biomd0000000876_model.initial_uninfected_cd4_t_cells",
        "description": "Initial Uninfected CD4 T Cells. Sets the initial value of bundled SBML species `C_Uninfected_CD4`."
      },
      {
        "name": "initial_infected_cd4_t_cells",
        "label": "Initial Infected CD4 T Cells",
        "units": "native source value",
        "default": 1,
        "maps_to": "immunology_sbml_aavani2019_the_role_of_cd4_t_cells_in_immune_sys_biomd0000000876_model.initial_infected_cd4_t_cells",
        "description": "Initial Infected CD4 T Cells. Sets the initial value of bundled SBML species `I_Infected_CD4`."
      },
      {
        "name": "initial_virus",
        "label": "Initial Virus",
        "units": "native source value",
        "default": 200,
        "maps_to": "immunology_sbml_aavani2019_the_role_of_cd4_t_cells_in_immune_sys_biomd0000000876_model.initial_virus",
        "description": "Initial Virus. Sets the initial value of bundled SBML species `V_Virus`."
      },
      {
        "name": "initial_cytotoxic_t_lymphocytes",
        "label": "Initial Cytotoxic T Lymphocytes",
        "units": "native source value",
        "default": 1,
        "maps_to": "immunology_sbml_aavani2019_the_role_of_cd4_t_cells_in_immune_sys_biomd0000000876_model.initial_cytotoxic_t_lymphocytes",
        "description": "Initial Cytotoxic T Lymphocytes. Sets the initial value of bundled SBML species `F_CTL`."
      },
      {
        "name": "cd4_uninfected_infection_rate",
        "label": "CD4 Uninfected Infection Rate",
        "units": "native source value",
        "default": 0.0000575,
        "maps_to": "immunology_sbml_aavani2019_the_role_of_cd4_t_cells_in_immune_sys_biomd0000000876_model.cd4_uninfected_infection_rate",
        "description": "CD4 Uninfected Infection Rate. Sets bundled SBML parameter `beta`."
      }
    ],
    "outputs": [
      {
        "name": "uninfected_cd4_t_cells",
        "maps_to": "immunology_sbml_aavani2019_the_role_of_cd4_t_cells_in_immune_sys_biomd0000000876_model.uninfected_cd4_t_cells"
      },
      {
        "name": "infected_cd4_t_cells",
        "maps_to": "immunology_sbml_aavani2019_the_role_of_cd4_t_cells_in_immune_sys_biomd0000000876_model.infected_cd4_t_cells"
      },
      {
        "name": "virus",
        "maps_to": "immunology_sbml_aavani2019_the_role_of_cd4_t_cells_in_immune_sys_biomd0000000876_model.virus"
      },
      {
        "name": "cytotoxic_t_lymphocytes",
        "maps_to": "immunology_sbml_aavani2019_the_role_of_cd4_t_cells_in_immune_sys_biomd0000000876_model.cytotoxic_t_lymphocytes"
      },
      {
        "name": "state",
        "maps_to": "immunology_sbml_aavani2019_the_role_of_cd4_t_cells_in_immune_sys_biomd0000000876_model.state"
      },
      {
        "name": "summary",
        "maps_to": "immunology_sbml_aavani2019_the_role_of_cd4_t_cells_in_immune_sys_biomd0000000876_model.summary"
      },
      {
        "name": "species_labels",
        "maps_to": "immunology_sbml_aavani2019_the_role_of_cd4_t_cells_in_immune_sys_biomd0000000876_model.species_labels"
      }
    ]
  },
  "title": "Aavani2019 - The role of CD4 T cells in immune system activation and viral reproduction in a simple model for HIV infection Lab",
  "models": [
    {
      "path": "owned/models/immunology_sbml_aavani2019_the_role_of_cd4_t_cells_in_immune_sys_biomd0000000876_model",
      "alias": "immunology_sbml_aavani2019_the_role_of_cd4_t_cells_in_immune_sys_biomd0000000876_model",
      "provenance": {
        "owned_path": "owned/models/immunology_sbml_aavani2019_the_role_of_cd4_t_cells_in_immune_sys_biomd0000000876_model"
      }
    },
    {
      "path": "owned/models/visualisation",
      "alias": "visualisation",
      "provenance": {
        "owned_path": "owned/models/visualisation"
      }
    }
  ],
  "wiring": [
    {
      "to": [
        "visualisation.immunology_sbml_aavani2019_the_role_of_cd4_t_cells_in_immune_sys_biomd0000000876_model_state"
      ],
      "from": "immunology_sbml_aavani2019_the_role_of_cd4_t_cells_in_immune_sys_biomd0000000876_model.state"
    },
    {
      "to": [
        "visualisation.immunology_sbml_aavani2019_the_role_of_cd4_t_cells_in_immune_sys_biomd0000000876_model_summary"
      ],
      "from": "immunology_sbml_aavani2019_the_role_of_cd4_t_cells_in_immune_sys_biomd0000000876_model.summary"
    },
    {
      "to": [
        "visualisation.immunology_sbml_aavani2019_the_role_of_cd4_t_cells_in_immune_sys_biomd0000000876_model_species_labels"
      ],
      "from": "immunology_sbml_aavani2019_the_role_of_cd4_t_cells_in_immune_sys_biomd0000000876_model.species_labels"
    }
  ],
  "runtime": {
    "duration": 10,
    "initial_inputs": {},
    "communication_step": 1
  },
  "description": "This is a mathematical model comprised of a simple system of four ordinary differential equations that account for the two opposing roles of infected and healthy cytotoxic T lymphocytes within the con. It can be used to explore immune response dynamics and compare pathway-level behavior across conditions.",
  "schema_version": "2.0"
}

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