Khandibharad2022 - IL-12 regulation by IL-10 in Leishmaniasis Lab

{
  "io": {
    "inputs": [
      {
        "name": "initial_uev1a_signaling_component",
        "label": "Initial Uev1a Signaling Component",
        "units": "MWBUILTINUNIT_molecule",
        "default": 1200,
        "maps_to": "immunology_sbml_khandibharad2022_il_12_regulation_by_il_10_in_le_model2012040002_model.initial_uev1a_signaling_component",
        "description": "Initial Uev1a Signaling Component. Sets the initial value of bundled SBML species `mwf17ae875_af88_4db8_9258_cd8beb914829`."
      },
      {
        "name": "initial_interferon_gamma",
        "label": "Initial Interferon Gamma",
        "units": "MWBUILTINUNIT_molecule",
        "default": 60,
        "maps_to": "immunology_sbml_khandibharad2022_il_12_regulation_by_il_10_in_le_model2012040002_model.initial_interferon_gamma",
        "description": "Initial Interferon Gamma. Sets the initial value of bundled SBML species `mw71e2a0cf_cc5b_4cd2_93ae_4e19d7cb4ace`."
      },
      {
        "name": "initial_interferon_g",
        "label": "Initial Interferon G",
        "units": "MWBUILTINUNIT_molecule",
        "default": 60,
        "maps_to": "immunology_sbml_khandibharad2022_il_12_regulation_by_il_10_in_le_model2012040002_model.initial_interferon_g",
        "description": "Initial Interferon G. Sets the initial value of bundled SBML species `mw1a35c486_7d05_4436_9876_766365a69447`."
      }
    ],
    "outputs": [
      {
        "name": "uev1a_signaling_component",
        "maps_to": "immunology_sbml_khandibharad2022_il_12_regulation_by_il_10_in_le_model2012040002_model.uev1a_signaling_component"
      },
      {
        "name": "ikb_p65_p50_complex",
        "maps_to": "immunology_sbml_khandibharad2022_il_12_regulation_by_il_10_in_le_model2012040002_model.ikb_p65_p50_complex"
      },
      {
        "name": "interferon_gamma",
        "maps_to": "immunology_sbml_khandibharad2022_il_12_regulation_by_il_10_in_le_model2012040002_model.interferon_gamma"
      },
      {
        "name": "interferon_g",
        "maps_to": "immunology_sbml_khandibharad2022_il_12_regulation_by_il_10_in_le_model2012040002_model.interferon_g"
      },
      {
        "name": "interferon_gamma_receptor",
        "maps_to": "immunology_sbml_khandibharad2022_il_12_regulation_by_il_10_in_le_model2012040002_model.interferon_gamma_receptor"
      },
      {
        "name": "state",
        "maps_to": "immunology_sbml_khandibharad2022_il_12_regulation_by_il_10_in_le_model2012040002_model.state"
      },
      {
        "name": "summary",
        "maps_to": "immunology_sbml_khandibharad2022_il_12_regulation_by_il_10_in_le_model2012040002_model.summary"
      },
      {
        "name": "species_labels",
        "maps_to": "immunology_sbml_khandibharad2022_il_12_regulation_by_il_10_in_le_model2012040002_model.species_labels"
      }
    ]
  },
  "title": "Khandibharad2022 - IL-12 regulation by IL-10 in Leishmaniasis Lab",
  "models": [
    {
      "path": "owned/models/immunology_sbml_khandibharad2022_il_12_regulation_by_il_10_in_le_model2012040002_model",
      "alias": "immunology_sbml_khandibharad2022_il_12_regulation_by_il_10_in_le_model2012040002_model",
      "provenance": {
        "owned_path": "owned/models/immunology_sbml_khandibharad2022_il_12_regulation_by_il_10_in_le_model2012040002_model"
      }
    },
    {
      "path": "owned/models/visualisation",
      "alias": "visualisation",
      "provenance": {
        "owned_path": "owned/models/visualisation"
      }
    }
  ],
  "wiring": [
    {
      "to": [
        "visualisation.immunology_sbml_khandibharad2022_il_12_regulation_by_il_10_in_le_model2012040002_model_state"
      ],
      "from": "immunology_sbml_khandibharad2022_il_12_regulation_by_il_10_in_le_model2012040002_model.state"
    },
    {
      "to": [
        "visualisation.immunology_sbml_khandibharad2022_il_12_regulation_by_il_10_in_le_model2012040002_model_summary"
      ],
      "from": "immunology_sbml_khandibharad2022_il_12_regulation_by_il_10_in_le_model2012040002_model.summary"
    },
    {
      "to": [
        "visualisation.immunology_sbml_khandibharad2022_il_12_regulation_by_il_10_in_le_model2012040002_model_species_labels"
      ],
      "from": "immunology_sbml_khandibharad2022_il_12_regulation_by_il_10_in_le_model2012040002_model.species_labels"
    }
  ],
  "runtime": {
    "duration": 10,
    "initial_inputs": {},
    "communication_step": 1
  },
  "description": "In this model, TLR2-TLR6 mediates MyD88 pathway gets activated, which activates IL-12 production and induces iNOS expression when the Macrophage is infected with Leishmania parasite. It can be used to explore immune response dynamics and compare pathway-level behavior across conditions.",
  "schema_version": "2.0"
}