Barros2021 - CARTmath, Mathematical Model of CAR-T Immunotherapy in Raji Cell Line Lab

{
  "io": {
    "inputs": [
      {
        "name": "epsilon_source_parameter",
        "label": "Epsilon source parameter",
        "units": "native SBML value",
        "default": 1.59795,
        "maps_to": "oncology_sbml_barros2021_cartmath_mathematical_model_of_car_t_biomd0000001020_model.epsilon_source_parameter",
        "description": "Epsilon source parameter. Maps to bundled SBML parameter `epsilon`."
      },
      {
        "name": "raji_ido_cart_19_1_mt_source_parameter",
        "label": "Raji IDO+CART 19+1MT source parameter",
        "units": "native SBML value",
        "default": 0,
        "maps_to": "oncology_sbml_barros2021_cartmath_mathematical_model_of_car_t_biomd0000001020_model.raji_ido_cart_19_1_mt_source_parameter",
        "description": "Raji IDO+CART 19+1MT source parameter. Maps to bundled SBML parameter `Raji_IDO_CART_19_1MT`."
      },
      {
        "name": "initial_for_raji_ido_cart_19_1_mt_source_parameter",
        "label": "for Raji IDO+CART 19+1MT source parameter",
        "units": "native SBML value",
        "default": 0,
        "maps_to": "oncology_sbml_barros2021_cartmath_mathematical_model_of_car_t_biomd0000001020_model.initial_for_raji_ido_cart_19_1_mt_source_parameter",
        "description": "Initial for Raji IDO+CART 19+1MT source parameter. Maps to bundled SBML parameter `ModelValue_10`."
      }
    ],
    "outputs": [
      {
        "name": "tumor_cells",
        "maps_to": "oncology_sbml_barros2021_cartmath_mathematical_model_of_car_t_biomd0000001020_model.tumor_cells",
        "description": "T observable. Maps to SBML symbol `T`."
      },
      {
        "name": "cm",
        "maps_to": "oncology_sbml_barros2021_cartmath_mathematical_model_of_car_t_biomd0000001020_model.cm",
        "description": "Cm observable. Maps to SBML symbol `Cm`."
      },
      {
        "name": "ct",
        "maps_to": "oncology_sbml_barros2021_cartmath_mathematical_model_of_car_t_biomd0000001020_model.ct",
        "description": "Ct observable. Maps to SBML symbol `Ct`."
      },
      {
        "name": "state",
        "maps_to": "oncology_sbml_barros2021_cartmath_mathematical_model_of_car_t_biomd0000001020_model.state",
        "description": "Full raw SBML observable record for reproducibility and downstream visualisation."
      },
      {
        "name": "summary",
        "maps_to": "oncology_sbml_barros2021_cartmath_mathematical_model_of_car_t_biomd0000001020_model.summary",
        "description": "Change and peak summary across the simulated SBML observables."
      },
      {
        "name": "species_labels",
        "maps_to": "oncology_sbml_barros2021_cartmath_mathematical_model_of_car_t_biomd0000001020_model.species_labels",
        "description": "Mapping from selected raw SBML observable symbols to display labels."
      }
    ]
  },
  "tags": [
    "biomodels_ebi",
    "car-t",
    "curated",
    "drug-response",
    "faithful",
    "immunology",
    "immunotherapy",
    "logical-model",
    "oncology",
    "pharmacology",
    "physiology",
    "sbml",
    "systemsbiology",
    "tumor-growth"
  ],
  "title": "Barros2021 - CARTmath, Mathematical Model of CAR-T Immunotherapy in Raji Cell Line Lab",
  "models": [
    {
      "path": "owned/models/oncology_sbml_barros2021_cartmath_mathematical_model_of_car_t_biomd0000001020_model",
      "alias": "oncology_sbml_barros2021_cartmath_mathematical_model_of_car_t_biomd0000001020_model",
      "provenance": {
        "owned_path": "owned/models/oncology_sbml_barros2021_cartmath_mathematical_model_of_car_t_biomd0000001020_model"
      }
    },
    {
      "path": "owned/models/visualisation",
      "alias": "visualisation",
      "provenance": {
        "owned_path": "owned/models/visualisation"
      }
    }
  ],
  "wiring": [
    {
      "to": [
        "visualisation.oncology_sbml_barros2021_cartmath_mathematical_model_of_car_t_biomd0000001020_model_state"
      ],
      "from": "oncology_sbml_barros2021_cartmath_mathematical_model_of_car_t_biomd0000001020_model.state"
    },
    {
      "to": [
        "visualisation.oncology_sbml_barros2021_cartmath_mathematical_model_of_car_t_biomd0000001020_model_summary"
      ],
      "from": "oncology_sbml_barros2021_cartmath_mathematical_model_of_car_t_biomd0000001020_model.summary"
    },
    {
      "to": [
        "visualisation.oncology_sbml_barros2021_cartmath_mathematical_model_of_car_t_biomd0000001020_model_species_labels"
      ],
      "from": "oncology_sbml_barros2021_cartmath_mathematical_model_of_car_t_biomd0000001020_model.species_labels"
    }
  ],
  "runtime": {
    "duration": 10,
    "initial_inputs": {},
    "communication_step": 1
  },
  "description": "A mathematical model (CART-math) studying the impact of CAR-T cells therapy on haematological cancer cell lines which in this case is RAJI. It can be used to explore tumor-related dynamics and compare treatment-response behavior across conditions.",
  "schema_version": "2.0"
}