About lab
This a model from the article: Metabolic engineering of lactic acid bacteria, the combined approach: kinetic modelling, metabolic control and experimental analysis. It can be used to explore metabolic flux dynamics and compare pathway behavior across conditions.
Runtime
Duration10
Comms Step1
Runs
Total0
Completed0
Failed0
Metadata
Packagehoefnagel2002-pyruvatebranches-lab
Created2026-05-15
Updated2026-05-15
biomodels_ebifaithfulmetabolismodesbmltelluriumvisualisation
Manifest
{
"io": {
"inputs": [
{
"name": "initial_adp",
"units": "native SBML value",
"default": 4.9,
"maps_to": "metabolism_sbml_hoefnagel2002_pyruvatebranches_biomd0000000017_model.initial_adp",
"description": "Initial condition for adp. Maps to bundled SBML symbol `ADP`. Applied before the Tellurium simulation starts; this does not change kinetic parameters or equations. Default from bundled SBML initial value."
},
{
"name": "initial_nad",
"units": "native SBML value",
"default": 6.33,
"maps_to": "metabolism_sbml_hoefnagel2002_pyruvatebranches_biomd0000000017_model.initial_nad",
"description": "Initial condition for nad. Maps to bundled SBML symbol `NAD`. Applied before the Tellurium simulation starts; this does not change kinetic parameters or equations. Default from bundled SBML initial value."
},
{
"name": "initial_atp",
"units": "native SBML value",
"default": 0.1,
"maps_to": "metabolism_sbml_hoefnagel2002_pyruvatebranches_biomd0000000017_model.initial_atp",
"description": "Initial condition for atp. Maps to bundled SBML symbol `ATP`. Applied before the Tellurium simulation starts; this does not change kinetic parameters or equations. Default from bundled SBML initial value."
},
{
"name": "initial_nadh",
"units": "native SBML value",
"default": 3.67,
"maps_to": "metabolism_sbml_hoefnagel2002_pyruvatebranches_biomd0000000017_model.initial_nadh",
"description": "Initial condition for nadh. Maps to bundled SBML symbol `NADH`. Applied before the Tellurium simulation starts; this does not change kinetic parameters or equations. Default from bundled SBML initial value."
},
{
"name": "initial_metabolic_pathway_state_5",
"units": "native SBML value",
"default": 1,
"maps_to": "metabolism_sbml_hoefnagel2002_pyruvatebranches_biomd0000000017_model.initial_metabolic_pathway_state_5",
"description": "Initial condition for metabolic pathway state 5. Maps to bundled SBML symbol `pyruvate`. Applied before the Tellurium simulation starts; this does not change kinetic parameters or equations. Default from bundled SBML initial value."
}
],
"outputs": [
{
"name": "adp",
"maps_to": "metabolism_sbml_hoefnagel2002_pyruvatebranches_biomd0000000017_model.adp"
},
{
"name": "nad",
"maps_to": "metabolism_sbml_hoefnagel2002_pyruvatebranches_biomd0000000017_model.nad"
},
{
"name": "atp",
"maps_to": "metabolism_sbml_hoefnagel2002_pyruvatebranches_biomd0000000017_model.atp"
},
{
"name": "nadh",
"maps_to": "metabolism_sbml_hoefnagel2002_pyruvatebranches_biomd0000000017_model.nadh"
},
{
"name": "metabolic_pathway_state_5",
"maps_to": "metabolism_sbml_hoefnagel2002_pyruvatebranches_biomd0000000017_model.metabolic_pathway_state_5"
},
{
"name": "observable_values",
"maps_to": "metabolism_sbml_hoefnagel2002_pyruvatebranches_biomd0000000017_model.observable_values"
},
{
"name": "run_summary",
"maps_to": "metabolism_sbml_hoefnagel2002_pyruvatebranches_biomd0000000017_model.run_summary"
},
{
"name": "observable_labels",
"maps_to": "metabolism_sbml_hoefnagel2002_pyruvatebranches_biomd0000000017_model.observable_labels"
}
]
},
"title": "Hoefnagel2002_PyruvateBranches Lab",
"models": [
{
"path": "owned/models/metabolism_sbml_hoefnagel2002_pyruvatebranches_biomd0000000017_model",
"alias": "metabolism_sbml_hoefnagel2002_pyruvatebranches_biomd0000000017_model",
"parameters": {
"model_path": "data/BIOMD0000000017.xml",
"integration_step": 0.1
},
"provenance": {
"owned_path": "owned/models/metabolism_sbml_hoefnagel2002_pyruvatebranches_biomd0000000017_model"
}
},
{
"path": "owned/models/visualisation",
"alias": "visualisation",
"provenance": {
"owned_path": "owned/models/visualisation"
}
}
],
"wiring": [
{
"to": [
"visualisation.metabolism_sbml_hoefnagel2002_pyruvatebranches_biomd0000000017_model_observable_values"
],
"from": "metabolism_sbml_hoefnagel2002_pyruvatebranches_biomd0000000017_model.observable_values"
},
{
"to": [
"visualisation.metabolism_sbml_hoefnagel2002_pyruvatebranches_biomd0000000017_model_run_summary"
],
"from": "metabolism_sbml_hoefnagel2002_pyruvatebranches_biomd0000000017_model.run_summary"
},
{
"to": [
"visualisation.metabolism_sbml_hoefnagel2002_pyruvatebranches_biomd0000000017_model_observable_labels"
],
"from": "metabolism_sbml_hoefnagel2002_pyruvatebranches_biomd0000000017_model.observable_labels"
}
],
"runtime": {
"duration": 10,
"initial_inputs": {},
"communication_step": 1
},
"description": "This a model from the article: Metabolic engineering of lactic acid bacteria, the combined approach: kinetic modelling, metabolic control and experimental analysis. It can be used to explore metabolic flux dynamics and compare pathway behavior across conditions.",
"schema_version": "2.0"
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