Bingzheng1990 - Zhenye Liansong Mathematical Regulation System Secretion Lab

About lab

Bingzheng1990 - Zhenye Liansong Mathematical Regulation System Secretion Lab

Scientific Source

Source type: PhysioMe CellML
Upstream ID: physiome:bingzheng_zhenye_liansong_1990
Original URL: https://models.physiomeproject.org/workspace/bingzheng_zhenye_liansong_1990
Bundled artifact: data/bingzheng_zhenye_liansong_1990.cellml

The bundled CellML/SBML artifact remains the scientific source of truth. This cleanup does not rewrite equations, parameters, units, or initial values; it exposes selected source symbols with conservative user-facing names.

Public Interface

Source-backed inputs:

initial_acth (Acth) maps to source symbol X2; units: pg_ml; evidence: source metadata names X2 as ACTH.
initial_cortisol (Cortisol) maps to source symbol X3; units: microg_dl; evidence: source metadata names X3 as cortisol.
The simulator still uses an internal integration_step parameter from the model manifest; it is not exposed as a biological lab input.

Selected outputs:

state, summary, trajectory, and variable_labels remain available for traceability.
acth (Acth) maps to source symbol X2; units: pg_ml; evidence: source metadata names X2 as ACTH.
cortisol (Cortisol) maps to source symbol X3; units: microg_dl; evidence: source metadata names X3 as cortisol.
crh (Crh) maps to source symbol X1; units: ng_ml; evidence: source metadata names X1 as CRH.
x1_a0 (X1 A0) maps to source symbol a0; units: ng_ml_min; evidence: source symbol, component, or units provide a direct public name.
x1_a1 (X1 A1) maps to source symbol a1; units: ng_ml_min; evidence: source symbol, component, or units provide a direct public name.
x1_a2 (X1 A2) maps to source symbol a2; units: dl_microg; evidence: source symbol, component, or units provide a direct public name.

Ambiguous source symbols are intentionally given conservative names such as model_state_*, cell_population_*, or rate_constant_* rather than unsupported biological interpretations.

Visualisations

Visual scope: Selected source-variable trajectories; final observable ranking; source/runtime evidence table; scientific Q/A.

The visualisation renders a scientific Q/A table, selected source-variable trajectories, final observable values, and source/runtime evidence. The cards use runtime outputs from the core wrapper and suppress empty data.

Output Visualizations

01-bingzheng1990-zhenye-liansong-mathematical-regulation-system-secretion-lab-physi

02-selected-physiology-trajectories

03-selected-final-observable-values

04-source-and-runtime-evidence

Caveat

This validates source-faithful execution and Biosimulant wiring for source-model physiology; it does not claim clinical safety or full reproduction of every upstream figure.

Source-faithful physiology lab for Bingzheng, Zhenye, Liansong, 1990. Public controls and outputs are mapped to real source symbols for source-model physiology.

Runtime

Duration0.01

Comms Step0.01

Settle Steps1

Runs

Total0

Completed0

Failed0

Metadata

Packagebingzheng1990-zhenye-liansong-mathematical-regulation-system-sec

Created2026-05-23

Updated2026-05-23

physiologycellmlphysiomefaithfulvisualisationother

Manifest

{
  "io": {
    "inputs": [
      {
        "name": "initial_acth",
        "label": "Initial Acth",
        "maps_to": "physiology_cellml_bingzheng_zhenye_liansong_1990_bingzhengzhenyeliansong1990_model.initial_acth",
        "description": "Initial value for Acth. Maps to source symbol `X2`. Units: pg_ml. Naming evidence: source metadata names `X2` as `ACTH`.",
        "accepted_units": [
          "pg_ml"
        ]
      },
      {
        "name": "initial_cortisol",
        "label": "Initial Cortisol",
        "maps_to": "physiology_cellml_bingzheng_zhenye_liansong_1990_bingzhengzhenyeliansong1990_model.initial_cortisol",
        "description": "Initial value for Cortisol. Maps to source symbol `X3`. Units: microg_dl. Naming evidence: source metadata names `X3` as `cortisol`.",
        "accepted_units": [
          "microg_dl"
        ]
      }
    ],
    "outputs": [
      {
        "name": "state",
        "label": "Selected Source State",
        "maps_to": "physiology_cellml_bingzheng_zhenye_liansong_1990_bingzhengzhenyeliansong1990_model.state"
      },
      {
        "name": "summary",
        "label": "Simulation Summary",
        "maps_to": "physiology_cellml_bingzheng_zhenye_liansong_1990_bingzhengzhenyeliansong1990_model.summary"
      },
      {
        "name": "trajectory",
        "label": "Source Trajectory",
        "maps_to": "physiology_cellml_bingzheng_zhenye_liansong_1990_bingzhengzhenyeliansong1990_model.trajectory"
      },
      {
        "name": "variable_labels",
        "label": "Observable Labels",
        "maps_to": "physiology_cellml_bingzheng_zhenye_liansong_1990_bingzhengzhenyeliansong1990_model.variable_labels"
      },
      {
        "name": "acth",
        "label": "Acth",
        "maps_to": "physiology_cellml_bingzheng_zhenye_liansong_1990_bingzhengzhenyeliansong1990_model.acth",
        "description": "Acth. Maps to source symbol `X2`. Units: pg_ml. Naming evidence: source metadata names `X2` as `ACTH`."
      },
      {
        "name": "cortisol",
        "label": "Cortisol",
        "maps_to": "physiology_cellml_bingzheng_zhenye_liansong_1990_bingzhengzhenyeliansong1990_model.cortisol",
        "description": "Cortisol. Maps to source symbol `X3`. Units: microg_dl. Naming evidence: source metadata names `X3` as `cortisol`."
      },
      {
        "name": "crh",
        "label": "Crh",
        "maps_to": "physiology_cellml_bingzheng_zhenye_liansong_1990_bingzhengzhenyeliansong1990_model.crh",
        "description": "Crh. Maps to source symbol `X1`. Units: ng_ml. Naming evidence: source metadata names `X1` as `CRH`."
      },
      {
        "name": "x1_a0",
        "label": "X1 A0",
        "maps_to": "physiology_cellml_bingzheng_zhenye_liansong_1990_bingzhengzhenyeliansong1990_model.x1_a0",
        "description": "X1 A0. Maps to source symbol `a0`. Units: ng_ml_min. Naming evidence: source symbol, component, or units provide a direct public name."
      },
      {
        "name": "x1_a1",
        "label": "X1 A1",
        "maps_to": "physiology_cellml_bingzheng_zhenye_liansong_1990_bingzhengzhenyeliansong1990_model.x1_a1",
        "description": "X1 A1. Maps to source symbol `a1`. Units: ng_ml_min. Naming evidence: source symbol, component, or units provide a direct public name."
      },
      {
        "name": "x1_a2",
        "label": "X1 A2",
        "maps_to": "physiology_cellml_bingzheng_zhenye_liansong_1990_bingzhengzhenyeliansong1990_model.x1_a2",
        "description": "X1 A2. Maps to source symbol `a2`. Units: dl_microg. Naming evidence: source symbol, component, or units provide a direct public name."
      }
    ]
  },
  "title": "Bingzheng1990 - Zhenye Liansong Mathematical Regulation System Secretion Lab",
  "models": [
    {
      "path": "owned/models/physiology_cellml_bingzheng_zhenye_liansong_1990_bingzhengzhenyeliansong1990_model",
      "alias": "physiology_cellml_bingzheng_zhenye_liansong_1990_bingzhengzhenyeliansong1990_model",
      "parameters": {
        "model_path": "data/bingzheng_zhenye_liansong_1990.cellml",
        "integration_step": 0.01
      },
      "provenance": {
        "owned_path": "owned/models/physiology_cellml_bingzheng_zhenye_liansong_1990_bingzhengzhenyeliansong1990_model"
      }
    },
    {
      "path": "owned/models/visualisation",
      "alias": "visualisation",
      "provenance": {
        "owned_path": "owned/models/visualisation"
      }
    }
  ],
  "wiring": [
    {
      "to": [
        "visualisation.physiology_cellml_bingzheng_zhenye_liansong_1990_bingzhengzhenyeliansong1990_model_state"
      ],
      "from": "physiology_cellml_bingzheng_zhenye_liansong_1990_bingzhengzhenyeliansong1990_model.state"
    },
    {
      "to": [
        "visualisation.physiology_cellml_bingzheng_zhenye_liansong_1990_bingzhengzhenyeliansong1990_model_summary"
      ],
      "from": "physiology_cellml_bingzheng_zhenye_liansong_1990_bingzhengzhenyeliansong1990_model.summary"
    },
    {
      "to": [
        "visualisation.physiology_cellml_bingzheng_zhenye_liansong_1990_bingzhengzhenyeliansong1990_model_trajectory"
      ],
      "from": "physiology_cellml_bingzheng_zhenye_liansong_1990_bingzhengzhenyeliansong1990_model.trajectory"
    },
    {
      "to": [
        "visualisation.physiology_cellml_bingzheng_zhenye_liansong_1990_bingzhengzhenyeliansong1990_model_variable_labels"
      ],
      "from": "physiology_cellml_bingzheng_zhenye_liansong_1990_bingzhengzhenyeliansong1990_model.variable_labels"
    }
  ],
  "runtime": {
    "duration": 0.01,
    "settle_steps": 1,
    "initial_inputs": {},
    "communication_step": 0.01
  },
  "description": "Source-faithful physiology lab for Bingzheng, Zhenye, Liansong, 1990. Public controls and outputs are mapped to real source symbols for source-model physiology.",
  "schema_version": "2.0"
}

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