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Lockwood2006 - Application Clinical Trial Simulation Compare Proof Lab

About lab

Source-faithful physiology lab for Lockwood, Ewy, Hermann, Holford, 2006. Public controls and outputs are mapped to real source symbols for pharmacokinetics.

Runtime

Duration0.01
Comms Step0.01
Settle Steps1

Runs

Total0
Completed0
Failed0

Metadata

Packagelockwood2006-application-clinical-trial-simulation-compare-proof
Created2026-05-23
Updated2026-05-23
physiologycellmlphysiomefaithfulvisualisationother

Manifest

{
  "io": {
    "inputs": [
      {
        "name": "initial_drug_clearance_cc",
        "label": "Initial Drug Clearance Cc",
        "maps_to": "physiology_cellml_lockwood_ewy_hermann_holford_2006_lockwoodewyhermannholford2006_model.initial_drug_clearance_cc",
        "description": "Initial value for Drug Clearance Cc. Maps to source symbol `CC`. Units: mg_per_litre. Naming evidence: source symbol, component, or units provide a direct public name.",
        "accepted_units": [
          "mg_per_litre"
        ]
      },
      {
        "name": "initial_drug_clearance_pc",
        "label": "Initial Drug Clearance Pc",
        "maps_to": "physiology_cellml_lockwood_ewy_hermann_holford_2006_lockwoodewyhermannholford2006_model.initial_drug_clearance_pc",
        "description": "Initial value for Drug Clearance Pc. Maps to source symbol `PC`. Units: mg_per_litre. Naming evidence: source symbol, component, or units provide a direct public name.",
        "accepted_units": [
          "mg_per_litre"
        ]
      }
    ],
    "outputs": [
      {
        "name": "state",
        "label": "Selected Source State",
        "maps_to": "physiology_cellml_lockwood_ewy_hermann_holford_2006_lockwoodewyhermannholford2006_model.state"
      },
      {
        "name": "summary",
        "label": "Simulation Summary",
        "maps_to": "physiology_cellml_lockwood_ewy_hermann_holford_2006_lockwoodewyhermannholford2006_model.summary"
      },
      {
        "name": "trajectory",
        "label": "Source Trajectory",
        "maps_to": "physiology_cellml_lockwood_ewy_hermann_holford_2006_lockwoodewyhermannholford2006_model.trajectory"
      },
      {
        "name": "variable_labels",
        "label": "Observable Labels",
        "maps_to": "physiology_cellml_lockwood_ewy_hermann_holford_2006_lockwoodewyhermannholford2006_model.variable_labels"
      },
      {
        "name": "drug_clearance_cc",
        "label": "Drug Clearance Cc",
        "maps_to": "physiology_cellml_lockwood_ewy_hermann_holford_2006_lockwoodewyhermannholford2006_model.drug_clearance_cc",
        "description": "Drug Clearance Cc. Maps to source symbol `CC`. Units: mg_per_litre. Naming evidence: source symbol, component, or units provide a direct public name."
      },
      {
        "name": "drug_clearance_pc",
        "label": "Drug Clearance Pc",
        "maps_to": "physiology_cellml_lockwood_ewy_hermann_holford_2006_lockwoodewyhermannholford2006_model.drug_clearance_pc",
        "description": "Drug Clearance Pc. Maps to source symbol `PC`. Units: mg_per_litre. Naming evidence: source symbol, component, or units provide a direct public name."
      },
      {
        "name": "model_state_a_in",
        "label": "Model State A In (source A_in)",
        "maps_to": "physiology_cellml_lockwood_ewy_hermann_holford_2006_lockwoodewyhermannholford2006_model.model_state_a_in",
        "description": "Model State A In (source A_in). Maps to source symbol `A_in`. Units: mg. Naming evidence: source symbol is too ambiguous for a stronger public label."
      },
      {
        "name": "beta_a",
        "label": "Beta A",
        "maps_to": "physiology_cellml_lockwood_ewy_hermann_holford_2006_lockwoodewyhermannholford2006_model.beta_a",
        "description": "Beta A. Maps to source symbol `beta_a`. Units: units_ml_per_ng. Naming evidence: source symbol, component, or units provide a direct public name."
      },
      {
        "name": "ce_a",
        "label": "Ce A",
        "maps_to": "physiology_cellml_lockwood_ewy_hermann_holford_2006_lockwoodewyhermannholford2006_model.ce_a",
        "description": "Ce A. Maps to source symbol `CeA`. Units: ng_per_ml. Naming evidence: source symbol, component, or units provide a direct public name."
      },
      {
        "name": "cl_ic",
        "label": "Cl Ic",
        "maps_to": "physiology_cellml_lockwood_ewy_hermann_holford_2006_lockwoodewyhermannholford2006_model.cl_ic",
        "description": "Cl Ic. Maps to source symbol `CL_ic`. Units: litre_per_day. Naming evidence: source symbol, component, or units provide a direct public name."
      }
    ]
  },
  "title": "Lockwood2006 - Application Clinical Trial Simulation Compare Proof Lab",
  "models": [
    {
      "path": "owned/models/physiology_cellml_lockwood_ewy_hermann_holford_2006_lockwoodewyhermannholford2006_model",
      "alias": "physiology_cellml_lockwood_ewy_hermann_holford_2006_lockwoodewyhermannholford2006_model",
      "parameters": {
        "model_path": "data/lockwood_ewy_hermann_holford_2006.cellml",
        "integration_step": 0.01
      },
      "provenance": {
        "owned_path": "owned/models/physiology_cellml_lockwood_ewy_hermann_holford_2006_lockwoodewyhermannholford2006_model"
      }
    },
    {
      "path": "owned/models/visualisation",
      "alias": "visualisation",
      "provenance": {
        "owned_path": "owned/models/visualisation"
      }
    }
  ],
  "wiring": [
    {
      "to": [
        "visualisation.physiology_cellml_lockwood_ewy_hermann_holford_2006_lockwoodewyhermannholford2006_model_state"
      ],
      "from": "physiology_cellml_lockwood_ewy_hermann_holford_2006_lockwoodewyhermannholford2006_model.state"
    },
    {
      "to": [
        "visualisation.physiology_cellml_lockwood_ewy_hermann_holford_2006_lockwoodewyhermannholford2006_model_summary"
      ],
      "from": "physiology_cellml_lockwood_ewy_hermann_holford_2006_lockwoodewyhermannholford2006_model.summary"
    },
    {
      "to": [
        "visualisation.physiology_cellml_lockwood_ewy_hermann_holford_2006_lockwoodewyhermannholford2006_model_trajectory"
      ],
      "from": "physiology_cellml_lockwood_ewy_hermann_holford_2006_lockwoodewyhermannholford2006_model.trajectory"
    },
    {
      "to": [
        "visualisation.physiology_cellml_lockwood_ewy_hermann_holford_2006_lockwoodewyhermannholford2006_model_variable_labels"
      ],
      "from": "physiology_cellml_lockwood_ewy_hermann_holford_2006_lockwoodewyhermannholford2006_model.variable_labels"
    }
  ],
  "runtime": {
    "duration": 0.01,
    "settle_steps": 1,
    "initial_inputs": {},
    "communication_step": 0.01
  },
  "description": "Source-faithful physiology lab for Lockwood, Ewy, Hermann, Holford, 2006. Public controls and outputs are mapped to real source symbols for pharmacokinetics.",
  "schema_version": "2.0"
}

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