Bianconi2012 - EGFR and IGF1R pathway in lung cancer Lab

{
  "io": {
    "inputs": [
      {
        "name": "gamma_egfr_source_parameter",
        "label": "Gamma EGFR source parameter",
        "units": "native SBML value",
        "default": 0.02,
        "maps_to": "oncology_sbml_bianconi2012_egfr_and_igf1r_pathway_in_lung_canc_biomd0000000427_model.gamma_egfr_source_parameter",
        "description": "Gamma EGFR source parameter. Maps to bundled SBML parameter `gamma_EGFR`."
      },
      {
        "name": "initial_egfr_active",
        "label": "EGFR active",
        "units": "native SBML value",
        "default": 8000,
        "maps_to": "oncology_sbml_bianconi2012_egfr_and_igf1r_pathway_in_lung_canc_biomd0000000427_model.initial_egfr_active",
        "description": "Initial EGFR active. Sets the initial value of bundled SBML symbol `EGFR_active`."
      },
      {
        "name": "initial_raf",
        "label": "Raf",
        "units": "native SBML value",
        "default": 120000,
        "maps_to": "oncology_sbml_bianconi2012_egfr_and_igf1r_pathway_in_lung_canc_biomd0000000427_model.initial_raf",
        "description": "Initial Raf. Sets the initial value of bundled SBML symbol `Raf`."
      },
      {
        "name": "initial_erk",
        "label": "ERK",
        "units": "native SBML value",
        "default": 600000,
        "maps_to": "oncology_sbml_bianconi2012_egfr_and_igf1r_pathway_in_lung_canc_biomd0000000427_model.initial_erk",
        "description": "Initial ERK. Sets the initial value of bundled SBML symbol `ERK`."
      },
      {
        "name": "initial_akt",
        "label": "AKT",
        "units": "native SBML value",
        "default": 600000,
        "maps_to": "oncology_sbml_bianconi2012_egfr_and_igf1r_pathway_in_lung_canc_biomd0000000427_model.initial_akt",
        "description": "Initial AKT. Sets the initial value of bundled SBML symbol `AKT`."
      },
      {
        "name": "initial_ras",
        "label": "Ras",
        "units": "native SBML value",
        "default": 120000,
        "maps_to": "oncology_sbml_bianconi2012_egfr_and_igf1r_pathway_in_lung_canc_biomd0000000427_model.initial_ras",
        "description": "Initial Ras. Sets the initial value of bundled SBML symbol `Ras`."
      }
    ],
    "outputs": [
      {
        "name": "egfr_active",
        "maps_to": "oncology_sbml_bianconi2012_egfr_and_igf1r_pathway_in_lung_canc_biomd0000000427_model.egfr_active",
        "description": "EGFR active observable. Maps to SBML symbol `EGFR_active`."
      },
      {
        "name": "raf",
        "maps_to": "oncology_sbml_bianconi2012_egfr_and_igf1r_pathway_in_lung_canc_biomd0000000427_model.raf",
        "description": "Raf observable. Maps to SBML symbol `Raf`."
      },
      {
        "name": "erk",
        "maps_to": "oncology_sbml_bianconi2012_egfr_and_igf1r_pathway_in_lung_canc_biomd0000000427_model.erk",
        "description": "ERK observable. Maps to SBML symbol `ERK`."
      },
      {
        "name": "akt",
        "maps_to": "oncology_sbml_bianconi2012_egfr_and_igf1r_pathway_in_lung_canc_biomd0000000427_model.akt",
        "description": "AKT observable. Maps to SBML symbol `AKT`."
      },
      {
        "name": "ras",
        "maps_to": "oncology_sbml_bianconi2012_egfr_and_igf1r_pathway_in_lung_canc_biomd0000000427_model.ras",
        "description": "Ras observable. Maps to SBML symbol `Ras`."
      },
      {
        "name": "pi3_kca",
        "maps_to": "oncology_sbml_bianconi2012_egfr_and_igf1r_pathway_in_lung_canc_biomd0000000427_model.pi3_kca",
        "description": "PI3KCA observable. Maps to SBML symbol `PI3KCA`."
      },
      {
        "name": "state",
        "maps_to": "oncology_sbml_bianconi2012_egfr_and_igf1r_pathway_in_lung_canc_biomd0000000427_model.state",
        "description": "Full raw SBML observable record for reproducibility and downstream visualisation."
      },
      {
        "name": "summary",
        "maps_to": "oncology_sbml_bianconi2012_egfr_and_igf1r_pathway_in_lung_canc_biomd0000000427_model.summary",
        "description": "Change and peak summary across the simulated SBML observables."
      },
      {
        "name": "species_labels",
        "maps_to": "oncology_sbml_bianconi2012_egfr_and_igf1r_pathway_in_lung_canc_biomd0000000427_model.species_labels",
        "description": "Mapping from selected raw SBML observable symbols to display labels."
      }
    ]
  },
  "tags": [
    "biomodels_ebi",
    "curated",
    "drug-response",
    "faithful",
    "immunology",
    "immunotherapy",
    "microenvironment",
    "oncology",
    "pharmacology",
    "physiology",
    "sbml",
    "signal-transduction",
    "signaling",
    "systemsbiology",
    "tumor-growth"
  ],
  "title": "Bianconi2012 - EGFR and IGF1R pathway in lung cancer Lab",
  "models": [
    {
      "path": "owned/models/oncology_sbml_bianconi2012_egfr_and_igf1r_pathway_in_lung_canc_biomd0000000427_model",
      "alias": "oncology_sbml_bianconi2012_egfr_and_igf1r_pathway_in_lung_canc_biomd0000000427_model",
      "provenance": {
        "owned_path": "owned/models/oncology_sbml_bianconi2012_egfr_and_igf1r_pathway_in_lung_canc_biomd0000000427_model"
      }
    },
    {
      "path": "owned/models/visualisation",
      "alias": "visualisation",
      "provenance": {
        "owned_path": "owned/models/visualisation"
      }
    }
  ],
  "wiring": [
    {
      "to": [
        "visualisation.oncology_sbml_bianconi2012_egfr_and_igf1r_pathway_in_lung_canc_biomd0000000427_model_state"
      ],
      "from": "oncology_sbml_bianconi2012_egfr_and_igf1r_pathway_in_lung_canc_biomd0000000427_model.state"
    },
    {
      "to": [
        "visualisation.oncology_sbml_bianconi2012_egfr_and_igf1r_pathway_in_lung_canc_biomd0000000427_model_summary"
      ],
      "from": "oncology_sbml_bianconi2012_egfr_and_igf1r_pathway_in_lung_canc_biomd0000000427_model.summary"
    },
    {
      "to": [
        "visualisation.oncology_sbml_bianconi2012_egfr_and_igf1r_pathway_in_lung_canc_biomd0000000427_model_species_labels"
      ],
      "from": "oncology_sbml_bianconi2012_egfr_and_igf1r_pathway_in_lung_canc_biomd0000000427_model.species_labels"
    }
  ],
  "runtime": {
    "duration": 10,
    "initial_inputs": {},
    "communication_step": 1
  },
  "description": "Bianconi2012 - EGFR and IGF1R pathway in lung cancer EGFR and IGF1R pathways play a key role in various human cancers and are crucial for tumour transformation and survival of malignant cells. It can be used to explore tumor-related dynamics and compare treatment-response behavior across conditions.",
  "schema_version": "2.0"
}