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Millard2023 - Gluconolactone-Gluconate extracellular bypass in Escherichia coli Lab

About lab

This model was used for instationary 13C metabolic flux analysis of the extracellular GL-GNT by-pass of E. It can be used to explore metabolic flux dynamics and compare pathway behavior across conditions.

Runtime

Duration10
Comms Step1

Runs

Total0
Completed0
Failed0

Metadata

Packagemillard2023-gluconolactone-gluconate-extracellular-bypass-in-esc
Created2026-05-15
Updated2026-05-15
biomodels_ebifaithfulmetabolismodesbmltelluriumvisualisation

Manifest

{
  "io": {
    "inputs": [
      {
        "name": "initial_microbial_metabolism_state_1",
        "units": "native SBML value",
        "default": 1,
        "maps_to": "metabolism_sbml_millard2023_gluconolactone_gluconate_extracellul_model2310250001_model.initial_microbial_metabolism_state_1",
        "description": "Initial condition for microbial metabolism state 1. Maps to bundled SBML symbol `G6P_0`. Applied before the Tellurium simulation starts; this does not change kinetic parameters or equations. Default from bundled SBML initial value."
      },
      {
        "name": "initial_microbial_metabolism_state_2",
        "units": "native SBML value",
        "default": 1,
        "maps_to": "metabolism_sbml_millard2023_gluconolactone_gluconate_extracellul_model2310250001_model.initial_microbial_metabolism_state_2",
        "description": "Initial condition for microbial metabolism state 2. Maps to bundled SBML symbol `GAP_0`. Applied before the Tellurium simulation starts; this does not change kinetic parameters or equations. Default from bundled SBML initial value."
      },
      {
        "name": "initial_microbial_metabolism_state_3",
        "units": "native SBML value",
        "default": 1,
        "maps_to": "metabolism_sbml_millard2023_gluconolactone_gluconate_extracellul_model2310250001_model.initial_microbial_metabolism_state_3",
        "description": "Initial condition for microbial metabolism state 3. Maps to bundled SBML symbol `PYR_0`. Applied before the Tellurium simulation starts; this does not change kinetic parameters or equations. Default from bundled SBML initial value."
      },
      {
        "name": "initial_observable_6pgl_0",
        "units": "native SBML value",
        "default": 1,
        "maps_to": "metabolism_sbml_millard2023_gluconolactone_gluconate_extracellul_model2310250001_model.initial_observable_6pgl_0",
        "description": "Initial condition for observable 6pgl 0. Maps to bundled SBML symbol `_6PGL_0`. Applied before the Tellurium simulation starts; this does not change kinetic parameters or equations. Default from bundled SBML initial value."
      },
      {
        "name": "initial_observable_6pg_0",
        "units": "native SBML value",
        "default": 1,
        "maps_to": "metabolism_sbml_millard2023_gluconolactone_gluconate_extracellul_model2310250001_model.initial_observable_6pg_0",
        "description": "Initial condition for observable 6pg 0. Maps to bundled SBML symbol `_6PG_0`. Applied before the Tellurium simulation starts; this does not change kinetic parameters or equations. Default from bundled SBML initial value."
      }
    ],
    "outputs": [
      {
        "name": "microbial_metabolism_state_1",
        "maps_to": "metabolism_sbml_millard2023_gluconolactone_gluconate_extracellul_model2310250001_model.microbial_metabolism_state_1"
      },
      {
        "name": "microbial_metabolism_state_2",
        "maps_to": "metabolism_sbml_millard2023_gluconolactone_gluconate_extracellul_model2310250001_model.microbial_metabolism_state_2"
      },
      {
        "name": "microbial_metabolism_state_3",
        "maps_to": "metabolism_sbml_millard2023_gluconolactone_gluconate_extracellul_model2310250001_model.microbial_metabolism_state_3"
      },
      {
        "name": "observable_6pgl_0",
        "maps_to": "metabolism_sbml_millard2023_gluconolactone_gluconate_extracellul_model2310250001_model.observable_6pgl_0"
      },
      {
        "name": "observable_6pg_0",
        "maps_to": "metabolism_sbml_millard2023_gluconolactone_gluconate_extracellul_model2310250001_model.observable_6pg_0"
      },
      {
        "name": "observable_values",
        "maps_to": "metabolism_sbml_millard2023_gluconolactone_gluconate_extracellul_model2310250001_model.observable_values"
      },
      {
        "name": "run_summary",
        "maps_to": "metabolism_sbml_millard2023_gluconolactone_gluconate_extracellul_model2310250001_model.run_summary"
      },
      {
        "name": "observable_labels",
        "maps_to": "metabolism_sbml_millard2023_gluconolactone_gluconate_extracellul_model2310250001_model.observable_labels"
      }
    ]
  },
  "title": "Millard2023 - Gluconolactone-Gluconate extracellular bypass in Escherichia coli Lab",
  "models": [
    {
      "path": "owned/models/metabolism_sbml_millard2023_gluconolactone_gluconate_extracellul_model2310250001_model",
      "alias": "metabolism_sbml_millard2023_gluconolactone_gluconate_extracellul_model2310250001_model",
      "parameters": {
        "model_path": "data/MODEL2310250001.xml",
        "integration_step": 0.1
      },
      "provenance": {
        "owned_path": "owned/models/metabolism_sbml_millard2023_gluconolactone_gluconate_extracellul_model2310250001_model"
      }
    },
    {
      "path": "owned/models/visualisation",
      "alias": "visualisation",
      "provenance": {
        "owned_path": "owned/models/visualisation"
      }
    }
  ],
  "wiring": [
    {
      "to": [
        "visualisation.metabolism_sbml_millard2023_gluconolactone_gluconate_extracellul_model2310250001_model_observable_values"
      ],
      "from": "metabolism_sbml_millard2023_gluconolactone_gluconate_extracellul_model2310250001_model.observable_values"
    },
    {
      "to": [
        "visualisation.metabolism_sbml_millard2023_gluconolactone_gluconate_extracellul_model2310250001_model_run_summary"
      ],
      "from": "metabolism_sbml_millard2023_gluconolactone_gluconate_extracellul_model2310250001_model.run_summary"
    },
    {
      "to": [
        "visualisation.metabolism_sbml_millard2023_gluconolactone_gluconate_extracellul_model2310250001_model_observable_labels"
      ],
      "from": "metabolism_sbml_millard2023_gluconolactone_gluconate_extracellul_model2310250001_model.observable_labels"
    }
  ],
  "runtime": {
    "duration": 10,
    "initial_inputs": {},
    "communication_step": 1
  },
  "description": "This model was used for instationary 13C metabolic flux analysis of the extracellular GL-GNT by-pass of E. It can be used to explore metabolic flux dynamics and compare pathway behavior across conditions.",
  "schema_version": "2.0"
}

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