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Begitt2014 - STAT1 cooperative DNA binding - single GAS polymer model Lab
Curated immunology lab using the bundled source model as the scientific source of truth.
What You'll See
This captured run documents the default Begitt2014 - STAT1 cooperative DNA binding - single GAS polymer model configuration for 10.0 time units with a 1.0 communication step. Default inputs include Initial Unresolved Signaling Observable 1, Initial DNA 000, Initial DNA 100, and Initial DNA 010. Reported outputs include unresolved_signaling_observable_1, dna_000, dna_100, and dna_010. The screenshots below pair the run-interpretation table with Immune signaling activity and Largest state excursions so the README shows both trajectories and the strongest state changes from the same dark-mode run.
Output Visualizations
The run-interpretation table summarizes the configured Begitt2014 - STAT1 cooperative DNA binding - single GAS polymer model simulation and its final-state diagnostics.
The Immune signaling activity time series follows the selected immune, pathogen, tumor, or signaling quantities across the simulated horizon.
The largest state excursions chart ranks the state variables that moved furthest during the run.
Begitt2014 - STAT1 cooperative DNA binding - single GAS polymer model The importance of STAT1-cooperative DNA binding in type 1 and type 2 interferon signalling has been studies using experimental and. It can be used to explore immune response dynamics and compare pathway-level behavior across conditions.
Runtime
Runs
Metadata
Manifest
{
"io": {
"inputs": [
{
"name": "initial_unresolved_signaling_observable_1",
"label": "Initial Unresolved Signaling Observable 1",
"units": "native source value",
"default": "1e-10",
"maps_to": "immunology_sbml_begitt2014_stat1_cooperative_dna_binding_single_biomd0000000500_model.initial_unresolved_signaling_observable_1",
"description": "Initial Unresolved Signaling Observable 1. Sets the initial value of bundled SBML species `S1`."
},
{
"name": "initial_dna_000",
"label": "Initial DNA 000",
"units": "native source value",
"default": "1e-10",
"maps_to": "immunology_sbml_begitt2014_stat1_cooperative_dna_binding_single_biomd0000000500_model.initial_dna_000",
"description": "Initial DNA 000. Sets the initial value of bundled SBML species `DNA_000`."
},
{
"name": "initial_dna_100",
"label": "Initial DNA 100",
"units": "native source value",
"default": 0,
"maps_to": "immunology_sbml_begitt2014_stat1_cooperative_dna_binding_single_biomd0000000500_model.initial_dna_100",
"description": "Initial DNA 100. Sets the initial value of bundled SBML species `DNA_100`."
},
{
"name": "initial_dna_010",
"label": "Initial DNA 010",
"units": "native source value",
"default": 0,
"maps_to": "immunology_sbml_begitt2014_stat1_cooperative_dna_binding_single_biomd0000000500_model.initial_dna_010",
"description": "Initial DNA 010. Sets the initial value of bundled SBML species `DNA_010`."
},
{
"name": "initial_dna_001",
"label": "Initial DNA 001",
"units": "native source value",
"default": 0,
"maps_to": "immunology_sbml_begitt2014_stat1_cooperative_dna_binding_single_biomd0000000500_model.initial_dna_001",
"description": "Initial DNA 001. Sets the initial value of bundled SBML species `DNA_001`."
}
],
"outputs": [
{
"name": "unresolved_signaling_observable_1",
"maps_to": "immunology_sbml_begitt2014_stat1_cooperative_dna_binding_single_biomd0000000500_model.unresolved_signaling_observable_1"
},
{
"name": "dna_000",
"maps_to": "immunology_sbml_begitt2014_stat1_cooperative_dna_binding_single_biomd0000000500_model.dna_000"
},
{
"name": "dna_100",
"maps_to": "immunology_sbml_begitt2014_stat1_cooperative_dna_binding_single_biomd0000000500_model.dna_100"
},
{
"name": "dna_010",
"maps_to": "immunology_sbml_begitt2014_stat1_cooperative_dna_binding_single_biomd0000000500_model.dna_010"
},
{
"name": "dna_001",
"maps_to": "immunology_sbml_begitt2014_stat1_cooperative_dna_binding_single_biomd0000000500_model.dna_001"
},
{
"name": "state",
"maps_to": "immunology_sbml_begitt2014_stat1_cooperative_dna_binding_single_biomd0000000500_model.state"
},
{
"name": "summary",
"maps_to": "immunology_sbml_begitt2014_stat1_cooperative_dna_binding_single_biomd0000000500_model.summary"
},
{
"name": "species_labels",
"maps_to": "immunology_sbml_begitt2014_stat1_cooperative_dna_binding_single_biomd0000000500_model.species_labels"
}
]
},
"title": "Begitt2014 - STAT1 cooperative DNA binding - single GAS polymer model Lab",
"models": [
{
"path": "owned/models/immunology_sbml_begitt2014_stat1_cooperative_dna_binding_single_biomd0000000500_model",
"alias": "immunology_sbml_begitt2014_stat1_cooperative_dna_binding_single_biomd0000000500_model",
"provenance": {
"owned_path": "owned/models/immunology_sbml_begitt2014_stat1_cooperative_dna_binding_single_biomd0000000500_model"
}
},
{
"path": "owned/models/visualisation",
"alias": "visualisation",
"provenance": {
"owned_path": "owned/models/visualisation"
}
}
],
"wiring": [
{
"to": [
"visualisation.immunology_sbml_begitt2014_stat1_cooperative_dna_binding_single_biomd0000000500_model_state"
],
"from": "immunology_sbml_begitt2014_stat1_cooperative_dna_binding_single_biomd0000000500_model.state"
},
{
"to": [
"visualisation.immunology_sbml_begitt2014_stat1_cooperative_dna_binding_single_biomd0000000500_model_summary"
],
"from": "immunology_sbml_begitt2014_stat1_cooperative_dna_binding_single_biomd0000000500_model.summary"
},
{
"to": [
"visualisation.immunology_sbml_begitt2014_stat1_cooperative_dna_binding_single_biomd0000000500_model_species_labels"
],
"from": "immunology_sbml_begitt2014_stat1_cooperative_dna_binding_single_biomd0000000500_model.species_labels"
}
],
"runtime": {
"duration": 10,
"initial_inputs": {},
"communication_step": 1
},
"description": "Begitt2014 - STAT1 cooperative DNA binding - single GAS polymer model The importance of STAT1-cooperative DNA binding in type 1 and type 2 interferon signalling has been studies using experimental and. It can be used to explore immune response dynamics and compare pathway-level behavior across conditions.",
"schema_version": "2.0"
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