About lab
NF-kB/IkB knockout signaling. The model corresponds to the knock out model of beta-/-, epsilon -/- and reproduces the upper panel in Fig 2C. In order to reproduce the other knock out models the transcription rate of the species th.
Runtime
Duration10
Comms Step1
Runs
Total0
Completed0
Failed0
Metadata
Packagehoffmann2002-nfkb-ikb-knockout
Created2026-05-15
Updated2026-06-13
generegulationsbmlbiomodels_ebifaithfulvisualisationother
Manifest
{
"io": {
"inputs": [],
"outputs": [
{
"name": "nfkb",
"maps_to": "hoffmann2002_nfkb_ikb_knockout.nfkb"
},
{
"name": "ikb_alpha",
"maps_to": "hoffmann2002_nfkb_ikb_knockout.ikb_alpha"
},
{
"name": "ikk",
"maps_to": "hoffmann2002_nfkb_ikb_knockout.ikk"
},
{
"name": "ikb_alpha_nfkb_complex",
"maps_to": "hoffmann2002_nfkb_ikb_knockout.ikb_alpha_nfkb_complex"
},
{
"name": "state",
"maps_to": "hoffmann2002_nfkb_ikb_knockout.state"
},
{
"name": "summary",
"maps_to": "hoffmann2002_nfkb_ikb_knockout.summary"
},
{
"name": "species_labels",
"maps_to": "hoffmann2002_nfkb_ikb_knockout.species_labels"
}
]
},
"title": "Hoffmann2002 Nfkb Ikb Knockout Lab",
"models": [
{
"path": "models/core",
"alias": "hoffmann2002_nfkb_ikb_knockout",
"parameters": {
"model_path": "data/BIOMD0000000139.xml",
"integration_step": 0.1
}
},
{
"path": "models/visualisation",
"alias": "visualisation"
}
],
"wiring": [
{
"to": [
"visualisation.hoffmann2002_nfkb_ikb_knockout_nfkb"
],
"from": "hoffmann2002_nfkb_ikb_knockout.nfkb"
},
{
"to": [
"visualisation.hoffmann2002_nfkb_ikb_knockout_ikb_alpha"
],
"from": "hoffmann2002_nfkb_ikb_knockout.ikb_alpha"
},
{
"to": [
"visualisation.hoffmann2002_nfkb_ikb_knockout_ikk"
],
"from": "hoffmann2002_nfkb_ikb_knockout.ikk"
},
{
"to": [
"visualisation.hoffmann2002_nfkb_ikb_knockout_ikb_alpha_nfkb_complex"
],
"from": "hoffmann2002_nfkb_ikb_knockout.ikb_alpha_nfkb_complex"
},
{
"to": [
"visualisation.hoffmann2002_nfkb_ikb_knockout_state"
],
"from": "hoffmann2002_nfkb_ikb_knockout.state"
},
{
"to": [
"visualisation.hoffmann2002_nfkb_ikb_knockout_summary"
],
"from": "hoffmann2002_nfkb_ikb_knockout.summary"
},
{
"to": [
"visualisation.hoffmann2002_nfkb_ikb_knockout_species_labels"
],
"from": "hoffmann2002_nfkb_ikb_knockout.species_labels"
}
],
"package": "hoffmann2002-nfkb-ikb-knockout",
"runtime": {
"duration": 10,
"initial_inputs": {},
"communication_step": 1
},
"version": "1.0.1",
"description": "NF-kB/IkB knockout signaling. The model corresponds to the knock out model of beta-/-, epsilon -/- and reproduces the upper panel in Fig 2C. In order to reproduce the other knock out models the transcription rate of the species th.",
"schema_version": "2.0"
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