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Hoffmann2002 Nfkb Ikb Knockout Lab

About lab

NF-kB/IkB knockout signaling. The model corresponds to the knock out model of beta-/-, epsilon -/- and reproduces the upper panel in Fig 2C. In order to reproduce the other knock out models the transcription rate of the species th.

Runtime

Duration10
Comms Step1

Runs

Total0
Completed0
Failed0

Metadata

Packagehoffmann2002-nfkb-ikb-knockout-lab
Created2026-05-15
Updated2026-05-15
generegulationsbmlbiomodels_ebifaithfulvisualisation

Manifest

{
  "io": {
    "inputs": [],
    "outputs": [
      {
        "name": "nfkb",
        "maps_to": "hoffmann2002_nfkb_ikb_knockout.nfkb"
      },
      {
        "name": "ikb_alpha",
        "maps_to": "hoffmann2002_nfkb_ikb_knockout.ikb_alpha"
      },
      {
        "name": "ikk",
        "maps_to": "hoffmann2002_nfkb_ikb_knockout.ikk"
      },
      {
        "name": "ikb_alpha_nfkb_complex",
        "maps_to": "hoffmann2002_nfkb_ikb_knockout.ikb_alpha_nfkb_complex"
      },
      {
        "name": "state",
        "maps_to": "hoffmann2002_nfkb_ikb_knockout.state"
      },
      {
        "name": "summary",
        "maps_to": "hoffmann2002_nfkb_ikb_knockout.summary"
      },
      {
        "name": "species_labels",
        "maps_to": "hoffmann2002_nfkb_ikb_knockout.species_labels"
      }
    ]
  },
  "title": "Hoffmann2002 Nfkb Ikb Knockout Lab",
  "models": [
    {
      "path": "owned/models/hoffmann2002_nfkb_ikb_knockout",
      "alias": "hoffmann2002_nfkb_ikb_knockout",
      "parameters": {
        "model_path": "data/BIOMD0000000139.xml",
        "integration_step": 0.1
      },
      "provenance": {
        "owned_path": "owned/models/hoffmann2002_nfkb_ikb_knockout"
      }
    },
    {
      "path": "owned/models/visualisation",
      "alias": "visualisation",
      "provenance": {
        "owned_path": "owned/models/visualisation"
      }
    }
  ],
  "wiring": [
    {
      "to": [
        "visualisation.hoffmann2002_nfkb_ikb_knockout_nfkb"
      ],
      "from": "hoffmann2002_nfkb_ikb_knockout.nfkb"
    },
    {
      "to": [
        "visualisation.hoffmann2002_nfkb_ikb_knockout_ikb_alpha"
      ],
      "from": "hoffmann2002_nfkb_ikb_knockout.ikb_alpha"
    },
    {
      "to": [
        "visualisation.hoffmann2002_nfkb_ikb_knockout_ikk"
      ],
      "from": "hoffmann2002_nfkb_ikb_knockout.ikk"
    },
    {
      "to": [
        "visualisation.hoffmann2002_nfkb_ikb_knockout_ikb_alpha_nfkb_complex"
      ],
      "from": "hoffmann2002_nfkb_ikb_knockout.ikb_alpha_nfkb_complex"
    },
    {
      "to": [
        "visualisation.hoffmann2002_nfkb_ikb_knockout_state"
      ],
      "from": "hoffmann2002_nfkb_ikb_knockout.state"
    },
    {
      "to": [
        "visualisation.hoffmann2002_nfkb_ikb_knockout_summary"
      ],
      "from": "hoffmann2002_nfkb_ikb_knockout.summary"
    },
    {
      "to": [
        "visualisation.hoffmann2002_nfkb_ikb_knockout_species_labels"
      ],
      "from": "hoffmann2002_nfkb_ikb_knockout.species_labels"
    }
  ],
  "runtime": {
    "duration": 10,
    "initial_inputs": {},
    "communication_step": 1
  },
  "description": "NF-kB/IkB knockout signaling. The model corresponds to the knock out model of beta-/-, epsilon -/- and reproduces the upper panel in Fig 2C. In order to reproduce the other knock out models the transcription rate of the species th.",
  "schema_version": "2.0"
}

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