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Jarrah2014 - mathematical model of the immune response in muscle degeneration and subsequent regeneration in Duchenne muscular dystrophy in mdx mice Lab

About lab

Duchenne muscular dystrophy (DMD) is a genetic disease that results in the death of affected boys by early adulthood.The genetic defect responsible for DMD has been known for over 25 years, yet at pre. It can be used to explore immune response dynamics and compare pathway-level behavior across conditions.

Runtime

Duration10
Comms Step1

Runs

Total0
Completed0
Failed0

Metadata

Packagejarrah2014-mathematical-model-of-the-immune-response-in-muscle-d
Created2026-05-15
Updated2026-05-15
immunologysbmlbiomodels_ebifaithfulcuratedvisualisation

Manifest

{
  "io": {
    "inputs": [
      {
        "name": "initial_cd4_t_helper_cells_h",
        "label": "Initial CD4 T Helper Cells H",
        "units": "substance",
        "default": 0,
        "maps_to": "immunology_sbml_jarrah2014_mathematical_model_of_the_immune_resp_biomd0000001015_model.initial_cd4_t_helper_cells_h",
        "description": "Initial CD4 T Helper Cells H. Sets the initial value of bundled SBML species `H`."
      },
      {
        "name": "initial_macrophages_m",
        "label": "Initial Macrophages M",
        "units": "substance",
        "default": 400,
        "maps_to": "immunology_sbml_jarrah2014_mathematical_model_of_the_immune_resp_biomd0000001015_model.initial_macrophages_m",
        "description": "Initial Macrophages M. Sets the initial value of bundled SBML species `M`."
      },
      {
        "name": "initial_cd8_cytotoxic_t_lymphocytes_c",
        "label": "Initial CD8 Cytotoxic T Lymphocytes C",
        "units": "substance",
        "default": 4,
        "maps_to": "immunology_sbml_jarrah2014_mathematical_model_of_the_immune_resp_biomd0000001015_model.initial_cd8_cytotoxic_t_lymphocytes_c",
        "description": "Initial CD8 Cytotoxic T Lymphocytes C. Sets the initial value of bundled SBML species `C`."
      },
      {
        "name": "initial_damaged_fibres_d",
        "label": "Initial Damaged Fibres D",
        "units": "substance",
        "default": 0,
        "maps_to": "immunology_sbml_jarrah2014_mathematical_model_of_the_immune_resp_biomd0000001015_model.initial_damaged_fibres_d",
        "description": "Initial Damaged Fibres D. Sets the initial value of bundled SBML species `D`."
      },
      {
        "name": "initial_normal_fibres_n",
        "label": "Initial Normal Fibres N",
        "units": "substance",
        "default": 100,
        "maps_to": "immunology_sbml_jarrah2014_mathematical_model_of_the_immune_resp_biomd0000001015_model.initial_normal_fibres_n",
        "description": "Initial Normal Fibres N. Sets the initial value of bundled SBML species `N`."
      }
    ],
    "outputs": [
      {
        "name": "cd4_t_helper_cells_h",
        "maps_to": "immunology_sbml_jarrah2014_mathematical_model_of_the_immune_resp_biomd0000001015_model.cd4_t_helper_cells_h"
      },
      {
        "name": "macrophages_m",
        "maps_to": "immunology_sbml_jarrah2014_mathematical_model_of_the_immune_resp_biomd0000001015_model.macrophages_m"
      },
      {
        "name": "cd8_cytotoxic_t_lymphocytes_c",
        "maps_to": "immunology_sbml_jarrah2014_mathematical_model_of_the_immune_resp_biomd0000001015_model.cd8_cytotoxic_t_lymphocytes_c"
      },
      {
        "name": "damaged_fibres_d",
        "maps_to": "immunology_sbml_jarrah2014_mathematical_model_of_the_immune_resp_biomd0000001015_model.damaged_fibres_d"
      },
      {
        "name": "normal_fibres_n",
        "maps_to": "immunology_sbml_jarrah2014_mathematical_model_of_the_immune_resp_biomd0000001015_model.normal_fibres_n"
      },
      {
        "name": "state",
        "maps_to": "immunology_sbml_jarrah2014_mathematical_model_of_the_immune_resp_biomd0000001015_model.state"
      },
      {
        "name": "summary",
        "maps_to": "immunology_sbml_jarrah2014_mathematical_model_of_the_immune_resp_biomd0000001015_model.summary"
      },
      {
        "name": "species_labels",
        "maps_to": "immunology_sbml_jarrah2014_mathematical_model_of_the_immune_resp_biomd0000001015_model.species_labels"
      }
    ]
  },
  "title": "Jarrah2014 - mathematical model of the immune response in muscle degeneration and subsequent regeneration in Duchenne muscular dystrophy in mdx mice Lab",
  "models": [
    {
      "path": "owned/models/immunology_sbml_jarrah2014_mathematical_model_of_the_immune_resp_biomd0000001015_model",
      "alias": "immunology_sbml_jarrah2014_mathematical_model_of_the_immune_resp_biomd0000001015_model",
      "provenance": {
        "owned_path": "owned/models/immunology_sbml_jarrah2014_mathematical_model_of_the_immune_resp_biomd0000001015_model"
      }
    },
    {
      "path": "owned/models/visualisation",
      "alias": "visualisation",
      "provenance": {
        "owned_path": "owned/models/visualisation"
      }
    }
  ],
  "wiring": [
    {
      "to": [
        "visualisation.immunology_sbml_jarrah2014_mathematical_model_of_the_immune_resp_biomd0000001015_model_state"
      ],
      "from": "immunology_sbml_jarrah2014_mathematical_model_of_the_immune_resp_biomd0000001015_model.state"
    },
    {
      "to": [
        "visualisation.immunology_sbml_jarrah2014_mathematical_model_of_the_immune_resp_biomd0000001015_model_summary"
      ],
      "from": "immunology_sbml_jarrah2014_mathematical_model_of_the_immune_resp_biomd0000001015_model.summary"
    },
    {
      "to": [
        "visualisation.immunology_sbml_jarrah2014_mathematical_model_of_the_immune_resp_biomd0000001015_model_species_labels"
      ],
      "from": "immunology_sbml_jarrah2014_mathematical_model_of_the_immune_resp_biomd0000001015_model.species_labels"
    }
  ],
  "runtime": {
    "duration": 10,
    "initial_inputs": {},
    "communication_step": 1
  },
  "description": "Duchenne muscular dystrophy (DMD) is a genetic disease that results in the death of affected boys by early adulthood.The genetic defect responsible for DMD has been known for over 25 years, yet at pre. It can be used to explore immune response dynamics and compare pathway-level behavior across conditions.",
  "schema_version": "2.0"
}

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