About lab
This paper describes the complex interactions between two extreme types of macrophages (M1 and M2 cells), effector T cells and an oncolytic Vesicular Stomatitis Virus (VSV), on the growth/elimination. It can be used to explore systemsbiology eftimie2019 macrophages plasticity BioModels0000000806 dynamics and compare simulation behavior across conditions.
Runtime
Duration1
Comms Step0.1
Runs
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Metadata
Packageeftimie2019-macrophages-plasticity-lab
Created2026-05-17
Updated2026-05-17
immunologyoncologysystemsbiologysbmlbiomodels_ebifaithfulcuratedvisualisation
Manifest
{
"io": {
"inputs": [
{
"name": "initial_virus_xv",
"label": "Initial Virus Xv",
"maps_to": "systemsbiology_sbml_eftimie2019_macrophages_plasticity_biomd0000000806_model.initial_virus_xv",
"description": "Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol `Virus_Xv`."
},
{
"name": "initial_m2_macrophage_xm2",
"label": "Initial M2 Macrophage XM2",
"maps_to": "systemsbiology_sbml_eftimie2019_macrophages_plasticity_biomd0000000806_model.initial_m2_macrophage_xm2",
"description": "Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol `M2_Macrophage_Xm2`."
},
{
"name": "initial_m1_macrophage_xm1",
"label": "Initial M1 Macrophage XM1",
"maps_to": "systemsbiology_sbml_eftimie2019_macrophages_plasticity_biomd0000000806_model.initial_m1_macrophage_xm1",
"description": "Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol `M1_Macrophage_Xm1`."
},
{
"name": "initial_infected_tumour_cells_xi",
"label": "Initial Infected Tumour Cells Xi",
"maps_to": "systemsbiology_sbml_eftimie2019_macrophages_plasticity_biomd0000000806_model.initial_infected_tumour_cells_xi",
"description": "Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol `Infected_Tumour_Cells_Xi`."
},
{
"name": "initial_un_infected_tumour_cells_xu",
"label": "Initial Un Infected Tumour Cells Xu",
"maps_to": "systemsbiology_sbml_eftimie2019_macrophages_plasticity_biomd0000000806_model.initial_un_infected_tumour_cells_xu",
"description": "Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol `UnInfected_Tumour_Cells_Xu`."
},
{
"name": "initial_effector_cytotoxic_cd8_t_cells_xe",
"label": "Initial Effector Cytotoxic CD8 T Cells Xe",
"maps_to": "systemsbiology_sbml_eftimie2019_macrophages_plasticity_biomd0000000806_model.initial_effector_cytotoxic_cd8_t_cells_xe",
"description": "Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol `Effector_Cytotoxic_CD8_TCells__Xe`."
}
],
"outputs": [
{
"name": "state",
"maps_to": "systemsbiology_sbml_eftimie2019_macrophages_plasticity_biomd0000000806_model.state"
},
{
"name": "summary",
"maps_to": "systemsbiology_sbml_eftimie2019_macrophages_plasticity_biomd0000000806_model.summary"
},
{
"name": "species_labels",
"maps_to": "systemsbiology_sbml_eftimie2019_macrophages_plasticity_biomd0000000806_model.species_labels"
},
{
"name": "virus_xv",
"maps_to": "systemsbiology_sbml_eftimie2019_macrophages_plasticity_biomd0000000806_model.virus_xv"
},
{
"name": "m2_macrophage_xm2",
"maps_to": "systemsbiology_sbml_eftimie2019_macrophages_plasticity_biomd0000000806_model.m2_macrophage_xm2"
},
{
"name": "m1_macrophage_xm1",
"maps_to": "systemsbiology_sbml_eftimie2019_macrophages_plasticity_biomd0000000806_model.m1_macrophage_xm1"
},
{
"name": "infected_tumour_cells_xi",
"maps_to": "systemsbiology_sbml_eftimie2019_macrophages_plasticity_biomd0000000806_model.infected_tumour_cells_xi"
},
{
"name": "un_infected_tumour_cells_xu",
"maps_to": "systemsbiology_sbml_eftimie2019_macrophages_plasticity_biomd0000000806_model.un_infected_tumour_cells_xu"
},
{
"name": "effector_cytotoxic_cd8_t_cells_xe",
"maps_to": "systemsbiology_sbml_eftimie2019_macrophages_plasticity_biomd0000000806_model.effector_cytotoxic_cd8_t_cells_xe"
}
]
},
"tags": [
"immunology",
"oncology",
"systemsbiology",
"sbml",
"biomodels_ebi",
"faithful",
"curated"
],
"title": "Eftimie2019 Macrophages Plasticity Lab",
"models": [
{
"path": "owned/models/systemsbiology_sbml_eftimie2019_macrophages_plasticity_biomd0000000806_model",
"alias": "systemsbiology_sbml_eftimie2019_macrophages_plasticity_biomd0000000806_model",
"provenance": {
"owned_path": "owned/models/systemsbiology_sbml_eftimie2019_macrophages_plasticity_biomd0000000806_model"
}
},
{
"path": "owned/models/visualisation",
"alias": "visualisation",
"provenance": {
"owned_path": "owned/models/visualisation"
}
}
],
"wiring": [
{
"to": [
"visualisation.systemsbiology_sbml_eftimie2019_macrophages_plasticity_biomd0000000806_model_state"
],
"from": "systemsbiology_sbml_eftimie2019_macrophages_plasticity_biomd0000000806_model.state"
},
{
"to": [
"visualisation.systemsbiology_sbml_eftimie2019_macrophages_plasticity_biomd0000000806_model_summary"
],
"from": "systemsbiology_sbml_eftimie2019_macrophages_plasticity_biomd0000000806_model.summary"
},
{
"to": [
"visualisation.systemsbiology_sbml_eftimie2019_macrophages_plasticity_biomd0000000806_model_species_labels"
],
"from": "systemsbiology_sbml_eftimie2019_macrophages_plasticity_biomd0000000806_model.species_labels"
}
],
"runtime": {
"duration": 1,
"initial_inputs": {},
"communication_step": 0.1
},
"description": "This paper describes the complex interactions between two extreme types of macrophages (M1 and M2 cells), effector T cells and an oncolytic Vesicular Stomatitis Virus (VSV), on the growth/elimination. It can be used to explore systemsbiology eftimie2019 macrophages plasticity BioModels0000000806 dynamics and compare simulation behavior across conditions.",
"schema_version": "2.0"
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