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Parton2018 - A model of Atherosclerosis and atheroma formation. Lab

About lab

SBML and SBGN-ML models of atherosclerosis and atheroma formation. This model is described in the publication: New models of atherosclerosis and multi-drug therapeutic interventions.

Runtime

Duration10
Comms Step0.5

Runs

Total0
Completed0
Failed0

Metadata

Packageparton2018-a-model-of-atherosclerosis-and-atheroma-formation-lab
Created2026-05-16
Updated2026-05-16
pharmacologycardiovascularphysiologyinflammationsystems-biologysbmltelluriumfaithfulbiomodels_ebivisualisation

Manifest

{
  "io": {
    "inputs": [
      {
        "name": "initial_ldl",
        "label": "Initial LDL",
        "maps_to": "pharmacology_sbml_parton2018_a_model_of_atherosclerosis_and_athero_model1812100001_model.initial_ldl"
      },
      {
        "name": "initial_hdl",
        "label": "Initial HDL",
        "maps_to": "pharmacology_sbml_parton2018_a_model_of_atherosclerosis_and_athero_model1812100001_model.initial_hdl"
      },
      {
        "name": "initial_free_oxygen_radicals",
        "label": "Initial Free Oxygen Radicals",
        "maps_to": "pharmacology_sbml_parton2018_a_model_of_atherosclerosis_and_athero_model1812100001_model.initial_free_oxygen_radicals"
      },
      {
        "name": "initial_monocytes",
        "label": "Initial Monocytes",
        "maps_to": "pharmacology_sbml_parton2018_a_model_of_atherosclerosis_and_athero_model1812100001_model.initial_monocytes"
      },
      {
        "name": "initial_t_cells",
        "label": "Initial T Cells",
        "maps_to": "pharmacology_sbml_parton2018_a_model_of_atherosclerosis_and_athero_model1812100001_model.initial_t_cells"
      }
    ],
    "outputs": [
      {
        "name": "state",
        "label": "Tracked source state",
        "maps_to": "pharmacology_sbml_parton2018_a_model_of_atherosclerosis_and_athero_model1812100001_model.state"
      },
      {
        "name": "summary",
        "label": "Simulation summary",
        "maps_to": "pharmacology_sbml_parton2018_a_model_of_atherosclerosis_and_athero_model1812100001_model.summary"
      },
      {
        "name": "species_labels",
        "label": "Observable labels",
        "maps_to": "pharmacology_sbml_parton2018_a_model_of_atherosclerosis_and_athero_model1812100001_model.species_labels"
      },
      {
        "name": "hdl",
        "label": "HDL",
        "maps_to": "pharmacology_sbml_parton2018_a_model_of_atherosclerosis_and_athero_model1812100001_model.hdl"
      },
      {
        "name": "ldl",
        "label": "LDL",
        "maps_to": "pharmacology_sbml_parton2018_a_model_of_atherosclerosis_and_athero_model1812100001_model.ldl"
      },
      {
        "name": "blood_ldl",
        "label": "Blood LDL",
        "maps_to": "pharmacology_sbml_parton2018_a_model_of_atherosclerosis_and_athero_model1812100001_model.blood_ldl"
      },
      {
        "name": "blood_hdl",
        "label": "Blood HDL",
        "maps_to": "pharmacology_sbml_parton2018_a_model_of_atherosclerosis_and_athero_model1812100001_model.blood_hdl"
      },
      {
        "name": "oxidized_ldl",
        "label": "Oxidized LDL",
        "maps_to": "pharmacology_sbml_parton2018_a_model_of_atherosclerosis_and_athero_model1812100001_model.oxidized_ldl"
      },
      {
        "name": "oxidized_hdl",
        "label": "Oxidized HDL",
        "maps_to": "pharmacology_sbml_parton2018_a_model_of_atherosclerosis_and_athero_model1812100001_model.oxidized_hdl"
      },
      {
        "name": "monocytes",
        "label": "Monocytes",
        "maps_to": "pharmacology_sbml_parton2018_a_model_of_atherosclerosis_and_athero_model1812100001_model.monocytes"
      },
      {
        "name": "macrophages",
        "label": "Macrophages",
        "maps_to": "pharmacology_sbml_parton2018_a_model_of_atherosclerosis_and_athero_model1812100001_model.macrophages"
      },
      {
        "name": "foam_cells",
        "label": "Foam Cells",
        "maps_to": "pharmacology_sbml_parton2018_a_model_of_atherosclerosis_and_athero_model1812100001_model.foam_cells"
      }
    ]
  },
  "tags": [
    "pharmacology",
    "cardiovascular",
    "physiology",
    "inflammation",
    "systems-biology",
    "sbml",
    "tellurium",
    "faithful",
    "biomodels_ebi"
  ],
  "title": "Parton2018 - A model of Atherosclerosis and atheroma formation. Lab",
  "models": [
    {
      "path": "owned/models/pharmacology_sbml_parton2018_a_model_of_atherosclerosis_and_athero_model1812100001_model",
      "alias": "pharmacology_sbml_parton2018_a_model_of_atherosclerosis_and_athero_model1812100001_model",
      "parameters": {
        "model_path": "data/MODEL1812100001.xml",
        "integration_step": 0.05
      },
      "provenance": {
        "owned_path": "owned/models/pharmacology_sbml_parton2018_a_model_of_atherosclerosis_and_athero_model1812100001_model"
      }
    },
    {
      "path": "owned/models/visualisation",
      "alias": "visualisation",
      "provenance": {
        "owned_path": "owned/models/visualisation"
      }
    }
  ],
  "wiring": [
    {
      "to": [
        "visualisation.pharmacology_sbml_parton2018_a_model_of_atherosclerosis_and_athero_model1812100001_model_state"
      ],
      "from": "pharmacology_sbml_parton2018_a_model_of_atherosclerosis_and_athero_model1812100001_model.state"
    },
    {
      "to": [
        "visualisation.pharmacology_sbml_parton2018_a_model_of_atherosclerosis_and_athero_model1812100001_model_summary"
      ],
      "from": "pharmacology_sbml_parton2018_a_model_of_atherosclerosis_and_athero_model1812100001_model.summary"
    },
    {
      "to": [
        "visualisation.pharmacology_sbml_parton2018_a_model_of_atherosclerosis_and_athero_model1812100001_model_species_labels"
      ],
      "from": "pharmacology_sbml_parton2018_a_model_of_atherosclerosis_and_athero_model1812100001_model.species_labels"
    }
  ],
  "runtime": {
    "duration": 10,
    "initial_inputs": {},
    "communication_step": 0.5
  },
  "description": "SBML and SBGN-ML models of atherosclerosis and atheroma formation. This model is described in the publication: New models of atherosclerosis and multi-drug therapeutic interventions.",
  "schema_version": "2.0"
}

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