{
  "io": {
    "inputs": [
      {
        "name": "initial_calcium_in_nucleus",
        "label": "Initial Calcium In Nucleus",
        "maps_to": "systemsbiology_sbml_fisher2006_ca_oscillation_dpdnt_nfat_dynamics_biomd0000000122_model.initial_calcium_in_nucleus",
        "description": "Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol `Ca_Nuc`."
      },
      {
        "name": "initial_calcium_in_cytosol",
        "label": "Initial Calcium In Cytosol",
        "maps_to": "systemsbiology_sbml_fisher2006_ca_oscillation_dpdnt_nfat_dynamics_biomd0000000122_model.initial_calcium_in_cytosol",
        "description": "Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol `Ca_Cyt`."
      },
      {
        "name": "initial_inactive_calcineurin_in_nucleus",
        "label": "Initial Inactive Calcineurin In Nucleus",
        "maps_to": "systemsbiology_sbml_fisher2006_ca_oscillation_dpdnt_nfat_dynamics_biomd0000000122_model.initial_inactive_calcineurin_in_nucleus",
        "description": "Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol `Inact_C_Nuc`."
      },
      {
        "name": "initial_inactive_calcineurin_in_cytosol",
        "label": "Initial Inactive Calcineurin In Cytosol",
        "maps_to": "systemsbiology_sbml_fisher2006_ca_oscillation_dpdnt_nfat_dynamics_biomd0000000122_model.initial_inactive_calcineurin_in_cytosol",
        "description": "Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol `Inact_C_Cyt`."
      },
      {
        "name": "initial_phosphorylated_nfat_in_cytosol",
        "label": "Initial Phosphorylated Nfat In Cytosol",
        "maps_to": "systemsbiology_sbml_fisher2006_ca_oscillation_dpdnt_nfat_dynamics_biomd0000000122_model.initial_phosphorylated_nfat_in_cytosol",
        "description": "Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol `NFAT_Pi_Cyt`."
      },
      {
        "name": "initial_nfat_calcineurin_complex_in_nucleus",
        "label": "Initial Nfat Calcineurin Complex In Nucleus",
        "maps_to": "systemsbiology_sbml_fisher2006_ca_oscillation_dpdnt_nfat_dynamics_biomd0000000122_model.initial_nfat_calcineurin_complex_in_nucleus",
        "description": "Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol `NFAT_Act_C_Nuc`."
      }
    ],
    "outputs": [
      {
        "name": "state",
        "maps_to": "systemsbiology_sbml_fisher2006_ca_oscillation_dpdnt_nfat_dynamics_biomd0000000122_model.state"
      },
      {
        "name": "summary",
        "maps_to": "systemsbiology_sbml_fisher2006_ca_oscillation_dpdnt_nfat_dynamics_biomd0000000122_model.summary"
      },
      {
        "name": "species_labels",
        "maps_to": "systemsbiology_sbml_fisher2006_ca_oscillation_dpdnt_nfat_dynamics_biomd0000000122_model.species_labels"
      },
      {
        "name": "calcium_in_nucleus",
        "maps_to": "systemsbiology_sbml_fisher2006_ca_oscillation_dpdnt_nfat_dynamics_biomd0000000122_model.calcium_in_nucleus"
      },
      {
        "name": "calcium_in_cytosol",
        "maps_to": "systemsbiology_sbml_fisher2006_ca_oscillation_dpdnt_nfat_dynamics_biomd0000000122_model.calcium_in_cytosol"
      },
      {
        "name": "inactive_calcineurin_in_nucleus",
        "maps_to": "systemsbiology_sbml_fisher2006_ca_oscillation_dpdnt_nfat_dynamics_biomd0000000122_model.inactive_calcineurin_in_nucleus"
      },
      {
        "name": "inactive_calcineurin_in_cytosol",
        "maps_to": "systemsbiology_sbml_fisher2006_ca_oscillation_dpdnt_nfat_dynamics_biomd0000000122_model.inactive_calcineurin_in_cytosol"
      },
      {
        "name": "phosphorylated_nfat_in_cytosol",
        "maps_to": "systemsbiology_sbml_fisher2006_ca_oscillation_dpdnt_nfat_dynamics_biomd0000000122_model.phosphorylated_nfat_in_cytosol"
      },
      {
        "name": "nfat_calcineurin_complex_in_nucleus",
        "maps_to": "systemsbiology_sbml_fisher2006_ca_oscillation_dpdnt_nfat_dynamics_biomd0000000122_model.nfat_calcineurin_complex_in_nucleus"
      }
    ]
  },
  "tags": [
    "immunology",
    "physiology",
    "systemsbiology",
    "sbml",
    "biomodels_ebi",
    "faithful",
    "curated"
  ],
  "title": "Fisher2006 Ca Oscillation Dpdnt Nfat Dynamics Lab",
  "models": [
    {
      "path": "owned/models/systemsbiology_sbml_fisher2006_ca_oscillation_dpdnt_nfat_dynamics_biomd0000000122_model",
      "alias": "systemsbiology_sbml_fisher2006_ca_oscillation_dpdnt_nfat_dynamics_biomd0000000122_model",
      "provenance": {
        "owned_path": "owned/models/systemsbiology_sbml_fisher2006_ca_oscillation_dpdnt_nfat_dynamics_biomd0000000122_model"
      }
    },
    {
      "path": "owned/models/visualisation",
      "alias": "visualisation",
      "provenance": {
        "owned_path": "owned/models/visualisation"
      }
    }
  ],
  "wiring": [
    {
      "to": [
        "visualisation.systemsbiology_sbml_fisher2006_ca_oscillation_dpdnt_nfat_dynamics_biomd0000000122_model_state"
      ],
      "from": "systemsbiology_sbml_fisher2006_ca_oscillation_dpdnt_nfat_dynamics_biomd0000000122_model.state"
    },
    {
      "to": [
        "visualisation.systemsbiology_sbml_fisher2006_ca_oscillation_dpdnt_nfat_dynamics_biomd0000000122_model_summary"
      ],
      "from": "systemsbiology_sbml_fisher2006_ca_oscillation_dpdnt_nfat_dynamics_biomd0000000122_model.summary"
    },
    {
      "to": [
        "visualisation.systemsbiology_sbml_fisher2006_ca_oscillation_dpdnt_nfat_dynamics_biomd0000000122_model_species_labels"
      ],
      "from": "systemsbiology_sbml_fisher2006_ca_oscillation_dpdnt_nfat_dynamics_biomd0000000122_model.species_labels"
    }
  ],
  "runtime": {
    "duration": 1,
    "initial_inputs": {},
    "communication_step": 0.1
  },
  "description": "The model reproduces the calcium oscillation dependent activation-deactivation kinetics of nuclear factor of activated T cells (NFAT) as depicted in Fig 4a of the paper. It can be used to explore systemsbiology fisher2006 ca oscillation dpdnt nfat dynamics and compare simulation behavior across conditions.",
  "schema_version": "2.0"
}