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Hornberg2005 - Hornberg Binder Bruggeman Schoeberl Heinrich Wes Lab

About lab

Source-faithful physiology lab for Hornberg, Binder, Bruggeman, Schoeberl, Heinrich, Westerhoff, 2005. Public controls and outputs are mapped to real source symbols for source-model physiology.

Runtime

Duration0.01
Comms Step0.01
Settle Steps1

Runs

Total0
Completed0
Failed0

Metadata

Packagehornberg2005-hornberg-binder-bruggeman-schoeberl-heinrich-wes-la
Created2026-05-23
Updated2026-05-23
physiologycellmlphysiomefaithfulvisualisationother

Manifest

{
  "io": {
    "inputs": [
      {
        "name": "initial_egf",
        "label": "Initial Egf",
        "maps_to": "physiology_cellml_hornberg_binder_bruggeman_schoeberl_heinrich_wes_hornbergbinderbruggemanschoeberlheinrichwesterhoff2005_model.initial_egf",
        "description": "Initial value for Egf. Maps to source symbol `c1`. Units: molar. Naming evidence: source metadata names `c1` as `EGF`.",
        "accepted_units": [
          "molar"
        ]
      },
      {
        "name": "initial_egf_egfr",
        "label": "Initial Egf Egfr",
        "maps_to": "physiology_cellml_hornberg_binder_bruggeman_schoeberl_heinrich_wes_hornbergbinderbruggemanschoeberlheinrichwesterhoff2005_model.initial_egf_egfr",
        "description": "Initial value for Egf Egfr. Maps to source symbol `c3`. Units: molar. Naming evidence: source metadata names `c3` as `EGF-EGFR`.",
        "accepted_units": [
          "molar"
        ]
      }
    ],
    "outputs": [
      {
        "name": "state",
        "label": "Selected Source State",
        "maps_to": "physiology_cellml_hornberg_binder_bruggeman_schoeberl_heinrich_wes_hornbergbinderbruggemanschoeberlheinrichwesterhoff2005_model.state"
      },
      {
        "name": "summary",
        "label": "Simulation Summary",
        "maps_to": "physiology_cellml_hornberg_binder_bruggeman_schoeberl_heinrich_wes_hornbergbinderbruggemanschoeberlheinrichwesterhoff2005_model.summary"
      },
      {
        "name": "trajectory",
        "label": "Source Trajectory",
        "maps_to": "physiology_cellml_hornberg_binder_bruggeman_schoeberl_heinrich_wes_hornbergbinderbruggemanschoeberlheinrichwesterhoff2005_model.trajectory"
      },
      {
        "name": "variable_labels",
        "label": "Observable Labels",
        "maps_to": "physiology_cellml_hornberg_binder_bruggeman_schoeberl_heinrich_wes_hornbergbinderbruggemanschoeberlheinrichwesterhoff2005_model.variable_labels"
      },
      {
        "name": "egf_egfri",
        "label": "Egf Egfri",
        "maps_to": "physiology_cellml_hornberg_binder_bruggeman_schoeberl_heinrich_wes_hornbergbinderbruggemanschoeberlheinrichwesterhoff2005_model.egf_egfri",
        "description": "Egf Egfri. Maps to source symbol `c10`. Units: molar. Naming evidence: source metadata names `c10` as `EGF-EGFRi`."
      },
      {
        "name": "egf_egfri_2_c11",
        "label": "Egf Egfri 2 C11",
        "maps_to": "physiology_cellml_hornberg_binder_bruggeman_schoeberl_heinrich_wes_hornbergbinderbruggemanschoeberlheinrichwesterhoff2005_model.egf_egfri_2_c11",
        "description": "Egf Egfri 2 C11. Maps to source symbol `c11`. Units: molar. Naming evidence: source metadata names `c11` as `(EGF-EGFRi)2`."
      },
      {
        "name": "egf_egfri_2_gap_grb2_sos_deg",
        "label": "Egf Egfri 2 Gap Grb2 Sos Deg",
        "maps_to": "physiology_cellml_hornberg_binder_bruggeman_schoeberl_heinrich_wes_hornbergbinderbruggemanschoeberlheinrichwesterhoff2005_model.egf_egfri_2_gap_grb2_sos_deg",
        "description": "Egf Egfri 2 Gap Grb2 Sos Deg. Maps to source symbol `c100`. Units: molar. Naming evidence: source metadata names `c100` as `(EGF-EGFRi*)2-GAP-Grb2-Sos-deg`."
      },
      {
        "name": "sos_erk_pp",
        "label": "Sos Erk Pp",
        "maps_to": "physiology_cellml_hornberg_binder_bruggeman_schoeberl_heinrich_wes_hornbergbinderbruggemanschoeberlheinrichwesterhoff2005_model.sos_erk_pp",
        "description": "Sos Erk Pp. Maps to source symbol `c101`. Units: molar. Naming evidence: source metadata names `c101` as `Sos-ERK-PP`."
      },
      {
        "name": "sos_erki_pp",
        "label": "Sos Erki Pp",
        "maps_to": "physiology_cellml_hornberg_binder_bruggeman_schoeberl_heinrich_wes_hornbergbinderbruggemanschoeberlheinrichwesterhoff2005_model.sos_erki_pp",
        "description": "Sos Erki Pp. Maps to source symbol `c102`. Units: molar. Naming evidence: source metadata names `c102` as `Sos-ERKi-PP`."
      },
      {
        "name": "sosi",
        "label": "Sosi",
        "maps_to": "physiology_cellml_hornberg_binder_bruggeman_schoeberl_heinrich_wes_hornbergbinderbruggemanschoeberlheinrichwesterhoff2005_model.sosi",
        "description": "Sosi. Maps to source symbol `c103`. Units: molar. Naming evidence: source metadata names `c103` as `Sosi`."
      }
    ]
  },
  "title": "Hornberg2005 - Hornberg Binder Bruggeman Schoeberl Heinrich Wes Lab",
  "models": [
    {
      "path": "owned/models/physiology_cellml_hornberg_binder_bruggeman_schoeberl_heinrich_wes_hornbergbinderbruggemanschoeberlheinrichwesterhoff2005_model",
      "alias": "physiology_cellml_hornberg_binder_bruggeman_schoeberl_heinrich_wes_hornbergbinderbruggemanschoeberlheinrichwesterhoff2005_model",
      "parameters": {
        "model_path": "data/hornberg_binder_bruggeman_schoeberl_heinrich_westerhoff_2005.cellml",
        "integration_step": 0.01
      },
      "provenance": {
        "owned_path": "owned/models/physiology_cellml_hornberg_binder_bruggeman_schoeberl_heinrich_wes_hornbergbinderbruggemanschoeberlheinrichwesterhoff2005_model"
      }
    },
    {
      "path": "owned/models/visualisation",
      "alias": "visualisation",
      "provenance": {
        "owned_path": "owned/models/visualisation"
      }
    }
  ],
  "wiring": [
    {
      "to": [
        "visualisation.physiology_cellml_hornberg_binder_bruggeman_schoeberl_heinrich_wes_hornbergbinderbruggemanschoeberlheinrichwesterhoff2005_model_state"
      ],
      "from": "physiology_cellml_hornberg_binder_bruggeman_schoeberl_heinrich_wes_hornbergbinderbruggemanschoeberlheinrichwesterhoff2005_model.state"
    },
    {
      "to": [
        "visualisation.physiology_cellml_hornberg_binder_bruggeman_schoeberl_heinrich_wes_hornbergbinderbruggemanschoeberlheinrichwesterhoff2005_model_summary"
      ],
      "from": "physiology_cellml_hornberg_binder_bruggeman_schoeberl_heinrich_wes_hornbergbinderbruggemanschoeberlheinrichwesterhoff2005_model.summary"
    },
    {
      "to": [
        "visualisation.physiology_cellml_hornberg_binder_bruggeman_schoeberl_heinrich_wes_hornbergbinderbruggemanschoeberlheinrichwesterhoff2005_model_trajectory"
      ],
      "from": "physiology_cellml_hornberg_binder_bruggeman_schoeberl_heinrich_wes_hornbergbinderbruggemanschoeberlheinrichwesterhoff2005_model.trajectory"
    },
    {
      "to": [
        "visualisation.physiology_cellml_hornberg_binder_bruggeman_schoeberl_heinrich_wes_hornbergbinderbruggemanschoeberlheinrichwesterhoff2005_model_variable_labels"
      ],
      "from": "physiology_cellml_hornberg_binder_bruggeman_schoeberl_heinrich_wes_hornbergbinderbruggemanschoeberlheinrichwesterhoff2005_model.variable_labels"
    }
  ],
  "runtime": {
    "duration": 0.01,
    "settle_steps": 1,
    "initial_inputs": {},
    "communication_step": 0.01
  },
  "description": "Source-faithful physiology lab for Hornberg, Binder, Bruggeman, Schoeberl, Heinrich, Westerhoff, 2005. Public controls and outputs are mapped to real source symbols for source-model physiology.",
  "schema_version": "2.0"
}

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