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Chang2010_Reduced_Kidney_FBA Lab

About lab

This is the reduced kidney metabolic network described in the article Drug off-target effects predicted using structural analysis in the context of a metabolic network model. It can be used to explore dose-response dynamics and compare treatment scenarios across conditions.

Runtime

Duration5
Comms Step0.5

Runs

Total0
Completed0
Failed0

Metadata

Packagechang2010-reduced-kidney-fba-lab
Created2026-05-16
Updated2026-05-16
pharmacologymetabolismkidneysystems-biologyfbasbmltelluriumfaithfulbiomodels_ebivisualisation

Manifest

{
  "io": {
    "inputs": [
      {
        "name": "initial_cytosolic_atp",
        "label": "Initial Cytosolic ATP",
        "maps_to": "pharmacology_sbml_chang2010_reduced_kidney_fba_model1011080004_model.initial_cytosolic_atp"
      },
      {
        "name": "initial_mitochondrial_atp",
        "label": "Initial Mitochondrial ATP",
        "maps_to": "pharmacology_sbml_chang2010_reduced_kidney_fba_model1011080004_model.initial_mitochondrial_atp"
      },
      {
        "name": "initial_extracellular_glucose",
        "label": "Initial Extracellular Glucose",
        "maps_to": "pharmacology_sbml_chang2010_reduced_kidney_fba_model1011080004_model.initial_extracellular_glucose"
      },
      {
        "name": "initial_cytosolic_lactate",
        "label": "Initial Cytosolic Lactate",
        "maps_to": "pharmacology_sbml_chang2010_reduced_kidney_fba_model1011080004_model.initial_cytosolic_lactate"
      }
    ],
    "outputs": [
      {
        "name": "state",
        "label": "Tracked source state",
        "maps_to": "pharmacology_sbml_chang2010_reduced_kidney_fba_model1011080004_model.state"
      },
      {
        "name": "summary",
        "label": "Simulation summary",
        "maps_to": "pharmacology_sbml_chang2010_reduced_kidney_fba_model1011080004_model.summary"
      },
      {
        "name": "species_labels",
        "label": "Observable labels",
        "maps_to": "pharmacology_sbml_chang2010_reduced_kidney_fba_model1011080004_model.species_labels"
      },
      {
        "name": "cytosolic_atp",
        "label": "Cytosolic ATP",
        "maps_to": "pharmacology_sbml_chang2010_reduced_kidney_fba_model1011080004_model.cytosolic_atp"
      },
      {
        "name": "mitochondrial_atp",
        "label": "Mitochondrial ATP",
        "maps_to": "pharmacology_sbml_chang2010_reduced_kidney_fba_model1011080004_model.mitochondrial_atp"
      },
      {
        "name": "cytosolic_glucose",
        "label": "Cytosolic Glucose",
        "maps_to": "pharmacology_sbml_chang2010_reduced_kidney_fba_model1011080004_model.cytosolic_glucose"
      },
      {
        "name": "extracellular_glucose",
        "label": "Extracellular Glucose",
        "maps_to": "pharmacology_sbml_chang2010_reduced_kidney_fba_model1011080004_model.extracellular_glucose"
      },
      {
        "name": "cytosolic_lactate",
        "label": "Cytosolic Lactate",
        "maps_to": "pharmacology_sbml_chang2010_reduced_kidney_fba_model1011080004_model.cytosolic_lactate"
      },
      {
        "name": "extracellular_lactate",
        "label": "Extracellular Lactate",
        "maps_to": "pharmacology_sbml_chang2010_reduced_kidney_fba_model1011080004_model.extracellular_lactate"
      },
      {
        "name": "cytosolic_urea",
        "label": "Cytosolic Urea",
        "maps_to": "pharmacology_sbml_chang2010_reduced_kidney_fba_model1011080004_model.cytosolic_urea"
      }
    ]
  },
  "tags": [
    "pharmacology",
    "metabolism",
    "kidney",
    "systems-biology",
    "fba",
    "sbml",
    "tellurium",
    "faithful",
    "biomodels_ebi"
  ],
  "title": "Chang2010_Reduced_Kidney_FBA Lab",
  "models": [
    {
      "path": "owned/models/pharmacology_sbml_chang2010_reduced_kidney_fba_model1011080004_model",
      "alias": "pharmacology_sbml_chang2010_reduced_kidney_fba_model1011080004_model",
      "parameters": {
        "model_path": "data/MODEL1011080004.xml",
        "integration_step": 0.05
      },
      "provenance": {
        "owned_path": "owned/models/pharmacology_sbml_chang2010_reduced_kidney_fba_model1011080004_model"
      }
    },
    {
      "path": "owned/models/visualisation",
      "alias": "visualisation",
      "provenance": {
        "owned_path": "owned/models/visualisation"
      }
    }
  ],
  "wiring": [
    {
      "to": [
        "visualisation.pharmacology_sbml_chang2010_reduced_kidney_fba_model1011080004_model_state"
      ],
      "from": "pharmacology_sbml_chang2010_reduced_kidney_fba_model1011080004_model.state"
    },
    {
      "to": [
        "visualisation.pharmacology_sbml_chang2010_reduced_kidney_fba_model1011080004_model_summary"
      ],
      "from": "pharmacology_sbml_chang2010_reduced_kidney_fba_model1011080004_model.summary"
    },
    {
      "to": [
        "visualisation.pharmacology_sbml_chang2010_reduced_kidney_fba_model1011080004_model_species_labels"
      ],
      "from": "pharmacology_sbml_chang2010_reduced_kidney_fba_model1011080004_model.species_labels"
    }
  ],
  "runtime": {
    "duration": 5,
    "initial_inputs": {},
    "communication_step": 0.5
  },
  "description": "This is the reduced kidney metabolic network described in the article Drug off-target effects predicted using structural analysis in the context of a metabolic network model. It can be used to explore dose-response dynamics and compare treatment scenarios across conditions.",
  "schema_version": "2.0"
}

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