Hatzimanikatis1999-Regulation of the G1-S transition of the mammalian cell cycle. Lab

About lab

Hatzimanikatis1999-Regulation of the G1-S transition of the mammalian cell cycle. Lab

Single-model lab wrapper for Hatzimanikatis1999-Regulation of the G1-S transition of the mammalian cell cycle.. A mathematical model of regulation of the G1-S transition of the mammalian cell cycle has been formulated to organize available experimental molecular-level information in a systematic quantitative fr. It can be used to explore cell-cycle regulation dynamics and compare checkpoint behavior across conditions.

This lab is a single-model Biosimulant wrapper for a cell-cycle simulation. The captured run uses the lab defaults and renders the model outputs as dark-mode visualizations for quick inspection and README embedding.

Model Context

A mathematical model of regulation of the G1-S transition of the mammalian cell cycle has been formulated to organize available experimental molecular-level information in a systematic quantitative fr. It can be used to explore cell-cycle regulation dynamics and compare checkpoint behavior across conditions.

Core model: Hatzimanikatis1999-Regulation of the G1-S transition of the mammalian cell cycle.
Runtime used by the lab: duration 10, step 1
Controllable inputs: Model state E, Model state Kp, Model state RE
Primary outputs: Model state C (C), Model state K, Model state Rp
Tags: cellcycle, sbml, biomodels_ebi, faithful

Output Visualizations

The images below were generated from a Biosimulant lab run in dark mode. Each capture corresponds to one rendered visualization from the run output panel.

1. Hatzimanikatis1999 Regulation Of The G1 S Transition Of The Mammalian Cell Cycle

G1/S commitment view, focused on the regulatory variables that gate entry into DNA synthesis and cell-cycle progression.

hatzimanikatis1999 regulation of the g1 s transition of the mammalian cell cycle

2. Hatzimanikatis1999 Regulation Of The G1 S Transition Of The Mammalian Cell Cycle

G1/S commitment view, focused on the regulatory variables that gate entry into DNA synthesis and cell-cycle progression.

hatzimanikatis1999 regulation of the g1 s transition of the mammalian cell cycle

3. Hatzimanikatis1999 Regulation Of The G1 S Transition Of The Mammalian Cell Cycle

G1/S commitment view, focused on the regulatory variables that gate entry into DNA synthesis and cell-cycle progression.

hatzimanikatis1999 regulation of the g1 s transition of the mammalian cell cycle

4. Hatzimanikatis1999 Regulation Of The G1 S Transition Of The Mammalian Cell Cycle

G1/S commitment view, focused on the regulatory variables that gate entry into DNA synthesis and cell-cycle progression.

hatzimanikatis1999 regulation of the g1 s transition of the mammalian cell cycle

5. Hatzimanikatis1999 Regulation Of The G1 S Transition Of The Mammalian Cell Cycle

G1/S commitment view, focused on the regulatory variables that gate entry into DNA synthesis and cell-cycle progression.

hatzimanikatis1999 regulation of the g1 s transition of the mammalian cell cycle

How to Read This Run

Use the time-course plots to see transient and steady-state behavior, the range or snapshot charts to identify the variables with the strongest response, and any phase-portrait view to inspect coupled regulator movement through the simulated trajectory. For this cell-cycle lab, the most useful comparison is usually between checkpoint, commitment, and mitotic-exit variables because those signals define where the simulated system sits in the cycle.

Inputs

Input	Context
Model state E	Controls Model state E in the lab model via `cellcycle_sbml_hatzimanikatis1999_regulation_of_the_g1_s_transi_model2005070001_model.model_state_e`.
Model state Kp	Controls Model state Kp in the lab model via `cellcycle_sbml_hatzimanikatis1999_regulation_of_the_g1_s_transi_model2005070001_model.model_state_kp`.
Model state RE	Controls Model state RE in the lab model via `cellcycle_sbml_hatzimanikatis1999_regulation_of_the_g1_s_transi_model2005070001_model.model_state_re`.

Outputs

Output	Context
Model state C (C)	Tracks Model state C (C) in the lab model via `cellcycle_sbml_hatzimanikatis1999_regulation_of_the_g1_s_transi_model2005070001_model.model_state_c_c`.
Model state K	Tracks Model state K in the lab model via `cellcycle_sbml_hatzimanikatis1999_regulation_of_the_g1_s_transi_model2005070001_model.model_state_k`.
Model state Rp	Tracks Model state Rp in the lab model via `cellcycle_sbml_hatzimanikatis1999_regulation_of_the_g1_s_transi_model2005070001_model.model_state_rp`.

Lab Files

lab.yaml defines the Biosimulant lab wrapper, exposed inputs, outputs, and runtime settings.
wiring-layout.json stores the canvas layout used by the lab UI.
models/core/model.yaml contains the wrapped simulation model metadata.
models/core/README.md contains the source model notes and provenance.
models/visualisation/model.yaml defines the visualization model used to render the run outputs.
assets/ contains the generated dark-mode visualization captures embedded above.

Single-model lab wrapper for Hatzimanikatis1999-Regulation of the G1-S transition of the mammalian cell cycle.. A mathematical model of regulation of the G1-S transition of the mammalian cell cycle has been formulated to organize available experimental molecular-level information in a systematic quantitative fr. It can be used to explore cell-cycle regulation dynamics and compare checkpoint behavior across conditions.

Runtime

Duration10

Comms Step1

Runs

Total0

Completed0

Failed0

Metadata

Packagehatzimanikatis1999-regulation-of-the-g1-s-transition-of-the-mamm

Created2026-05-15

Updated2026-05-15

cellcyclesbmlbiomodels_ebifaithfulvisualisation

Manifest

{
  "io": {
    "inputs": [
      {
        "name": "model_state_e",
        "label": "Model state E",
        "maps_to": "cellcycle_sbml_hatzimanikatis1999_regulation_of_the_g1_s_transi_model2005070001_model.model_state_e",
        "description": "Controls Model state E in the lab model via `cellcycle_sbml_hatzimanikatis1999_regulation_of_the_g1_s_transi_model2005070001_model.model_state_e`."
      },
      {
        "name": "model_state_kp",
        "label": "Model state Kp",
        "maps_to": "cellcycle_sbml_hatzimanikatis1999_regulation_of_the_g1_s_transi_model2005070001_model.model_state_kp",
        "description": "Controls Model state Kp in the lab model via `cellcycle_sbml_hatzimanikatis1999_regulation_of_the_g1_s_transi_model2005070001_model.model_state_kp`."
      },
      {
        "name": "model_state_re",
        "label": "Model state RE",
        "maps_to": "cellcycle_sbml_hatzimanikatis1999_regulation_of_the_g1_s_transi_model2005070001_model.model_state_re",
        "description": "Controls Model state RE in the lab model via `cellcycle_sbml_hatzimanikatis1999_regulation_of_the_g1_s_transi_model2005070001_model.model_state_re`."
      }
    ],
    "outputs": [
      {
        "name": "model_state_c_c",
        "label": "Model state C (C)",
        "maps_to": "cellcycle_sbml_hatzimanikatis1999_regulation_of_the_g1_s_transi_model2005070001_model.model_state_c_c",
        "description": "Tracks Model state C (C) in the lab model via `cellcycle_sbml_hatzimanikatis1999_regulation_of_the_g1_s_transi_model2005070001_model.model_state_c_c`."
      },
      {
        "name": "model_state_k",
        "label": "Model state K",
        "maps_to": "cellcycle_sbml_hatzimanikatis1999_regulation_of_the_g1_s_transi_model2005070001_model.model_state_k",
        "description": "Tracks Model state K in the lab model via `cellcycle_sbml_hatzimanikatis1999_regulation_of_the_g1_s_transi_model2005070001_model.model_state_k`."
      },
      {
        "name": "model_state_rp",
        "label": "Model state Rp",
        "maps_to": "cellcycle_sbml_hatzimanikatis1999_regulation_of_the_g1_s_transi_model2005070001_model.model_state_rp",
        "description": "Tracks Model state Rp in the lab model via `cellcycle_sbml_hatzimanikatis1999_regulation_of_the_g1_s_transi_model2005070001_model.model_state_rp`."
      }
    ]
  },
  "title": "Hatzimanikatis1999-Regulation of the G1-S transition of the mammalian cell cycle. Lab",
  "models": [
    {
      "path": "owned/models/cellcycle_sbml_hatzimanikatis1999_regulation_of_the_g1_s_transi_model2005070001_model",
      "alias": "cellcycle_sbml_hatzimanikatis1999_regulation_of_the_g1_s_transi_model2005070001_model",
      "provenance": {
        "owned_path": "owned/models/cellcycle_sbml_hatzimanikatis1999_regulation_of_the_g1_s_transi_model2005070001_model"
      }
    },
    {
      "path": "owned/models/visualisation",
      "alias": "visualisation",
      "provenance": {
        "owned_path": "owned/models/visualisation"
      }
    }
  ],
  "wiring": [
    {
      "to": [
        "visualisation.cellcycle_sbml_hatzimanikatis1999_regulation_of_the_g1_s_transi_model2005070001_model_state"
      ],
      "from": "cellcycle_sbml_hatzimanikatis1999_regulation_of_the_g1_s_transi_model2005070001_model.state"
    },
    {
      "to": [
        "visualisation.cellcycle_sbml_hatzimanikatis1999_regulation_of_the_g1_s_transi_model2005070001_model_summary"
      ],
      "from": "cellcycle_sbml_hatzimanikatis1999_regulation_of_the_g1_s_transi_model2005070001_model.summary"
    },
    {
      "to": [
        "visualisation.cellcycle_sbml_hatzimanikatis1999_regulation_of_the_g1_s_transi_model2005070001_model_species_labels"
      ],
      "from": "cellcycle_sbml_hatzimanikatis1999_regulation_of_the_g1_s_transi_model2005070001_model.species_labels"
    }
  ],
  "runtime": {
    "duration": 10,
    "initial_inputs": {},
    "communication_step": 1
  },
  "description": "Single-model lab wrapper for Hatzimanikatis1999-Regulation of the G1-S transition of the mammalian cell cycle.. A mathematical model of regulation of the G1-S transition of the mammalian cell cycle has been formulated to organize available experimental molecular-level information in a systematic quantitative fr. It can be used to explore cell-cycle regulation dynamics and compare checkpoint behavior across conditions.",
  "schema_version": "2.0"
}

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