Obeyesekere1999 - Cell Cycle Behavior Dominated By Kinetics Pathway Lab

{
  "io": {
    "inputs": [
      {
        "name": "initial_unphosphorylated_free_rb",
        "label": "Initial Unphosphorylated Free Rb",
        "maps_to": "physiology_cellml_obeyesekere_zimmerman_tecarro_auchmuty_1999_obeyesekerezimmermantecarroauchmuty1999_model.initial_unphosphorylated_free_rb",
        "description": "Initial value for Unphosphorylated Free Rb. Maps to source symbol `R`. Units: dimensionless. Naming evidence: source metadata names `R` as `unphosphorylated, free RB`.",
        "accepted_units": [
          "dimensionless"
        ]
      },
      {
        "name": "initial_cyclin_d_cdk4_complex",
        "label": "Initial Cyclin D Cdk4 Complex",
        "maps_to": "physiology_cellml_obeyesekere_zimmerman_tecarro_auchmuty_1999_obeyesekerezimmermantecarroauchmuty1999_model.initial_cyclin_d_cdk4_complex",
        "description": "Initial value for Cyclin D Cdk4 Complex. Maps to source symbol `D`. Units: dimensionless. Naming evidence: source metadata names `D` as `cyclin D/cdk4 complex`.",
        "accepted_units": [
          "dimensionless"
        ]
      }
    ],
    "outputs": [
      {
        "name": "state",
        "label": "Selected Source State",
        "maps_to": "physiology_cellml_obeyesekere_zimmerman_tecarro_auchmuty_1999_obeyesekerezimmermantecarroauchmuty1999_model.state"
      },
      {
        "name": "summary",
        "label": "Simulation Summary",
        "maps_to": "physiology_cellml_obeyesekere_zimmerman_tecarro_auchmuty_1999_obeyesekerezimmermantecarroauchmuty1999_model.summary"
      },
      {
        "name": "trajectory",
        "label": "Source Trajectory",
        "maps_to": "physiology_cellml_obeyesekere_zimmerman_tecarro_auchmuty_1999_obeyesekerezimmermantecarroauchmuty1999_model.trajectory"
      },
      {
        "name": "variable_labels",
        "label": "Observable Labels",
        "maps_to": "physiology_cellml_obeyesekere_zimmerman_tecarro_auchmuty_1999_obeyesekerezimmermantecarroauchmuty1999_model.variable_labels"
      },
      {
        "name": "unphosphorylated_free_rb",
        "label": "Unphosphorylated Free Rb",
        "maps_to": "physiology_cellml_obeyesekere_zimmerman_tecarro_auchmuty_1999_obeyesekerezimmermantecarroauchmuty1999_model.unphosphorylated_free_rb",
        "description": "Unphosphorylated Free Rb. Maps to source symbol `R`. Units: dimensionless. Naming evidence: source metadata names `R` as `unphosphorylated, free RB`."
      },
      {
        "name": "cell_cycle_state_q_d",
        "label": "Cell Cycle State Q D (source q_D)",
        "maps_to": "physiology_cellml_obeyesekere_zimmerman_tecarro_auchmuty_1999_obeyesekerezimmermantecarroauchmuty1999_model.cell_cycle_state_q_d",
        "description": "Cell Cycle State Q D (source q_D). Maps to source symbol `q_D`. Units: dimensionless. Naming evidence: cell-cycle context supports a conservative source-state label."
      },
      {
        "name": "cyclin_d_cdk4_complex",
        "label": "Cyclin D Cdk4 Complex",
        "maps_to": "physiology_cellml_obeyesekere_zimmerman_tecarro_auchmuty_1999_obeyesekerezimmermantecarroauchmuty1999_model.cyclin_d_cdk4_complex",
        "description": "Cyclin D Cdk4 Complex. Maps to source symbol `D`. Units: dimensionless. Naming evidence: source metadata names `D` as `cyclin D/cdk4 complex`."
      },
      {
        "name": "cyclin_e_cdk2_complex",
        "label": "Cyclin E Cdk2 Complex",
        "maps_to": "physiology_cellml_obeyesekere_zimmerman_tecarro_auchmuty_1999_obeyesekerezimmermantecarroauchmuty1999_model.cyclin_e_cdk2_complex",
        "description": "Cyclin E Cdk2 Complex. Maps to source symbol `E`. Units: dimensionless. Naming evidence: source metadata names `E` as `cyclin E/cdk2 complex`."
      },
      {
        "name": "rb_e2_f_complex",
        "label": "Rb E2 F Complex",
        "maps_to": "physiology_cellml_obeyesekere_zimmerman_tecarro_auchmuty_1999_obeyesekerezimmermantecarroauchmuty1999_model.rb_e2_f_complex",
        "description": "Rb E2 F Complex. Maps to source symbol `R_S`. Units: dimensionless. Naming evidence: source metadata names `R_S` as `RB/E2F complex`."
      },
      {
        "name": "cell_progression_indicator_cpi",
        "label": "Cell Progression Indicator Cpi",
        "maps_to": "physiology_cellml_obeyesekere_zimmerman_tecarro_auchmuty_1999_obeyesekerezimmermantecarroauchmuty1999_model.cell_progression_indicator_cpi",
        "description": "Cell Progression Indicator Cpi. Maps to source symbol `X`. Units: dimensionless. Naming evidence: source metadata names `X` as `Cell Progression Indicator (CPI)`."
      }
    ]
  },
  "title": "Obeyesekere1999 - Cell Cycle Behavior Dominated By Kinetics Pathway Lab",
  "models": [
    {
      "path": "owned/models/physiology_cellml_obeyesekere_zimmerman_tecarro_auchmuty_1999_obeyesekerezimmermantecarroauchmuty1999_model",
      "alias": "physiology_cellml_obeyesekere_zimmerman_tecarro_auchmuty_1999_obeyesekerezimmermantecarroauchmuty1999_model",
      "parameters": {
        "model_path": "data/obeyesekere_zimmerman_tecarro_auchmuty_1999.cellml",
        "integration_step": 0.01
      },
      "provenance": {
        "owned_path": "owned/models/physiology_cellml_obeyesekere_zimmerman_tecarro_auchmuty_1999_obeyesekerezimmermantecarroauchmuty1999_model"
      }
    },
    {
      "path": "owned/models/visualisation",
      "alias": "visualisation",
      "provenance": {
        "owned_path": "owned/models/visualisation"
      }
    }
  ],
  "wiring": [
    {
      "to": [
        "visualisation.physiology_cellml_obeyesekere_zimmerman_tecarro_auchmuty_1999_obeyesekerezimmermantecarroauchmuty1999_model_state"
      ],
      "from": "physiology_cellml_obeyesekere_zimmerman_tecarro_auchmuty_1999_obeyesekerezimmermantecarroauchmuty1999_model.state"
    },
    {
      "to": [
        "visualisation.physiology_cellml_obeyesekere_zimmerman_tecarro_auchmuty_1999_obeyesekerezimmermantecarroauchmuty1999_model_summary"
      ],
      "from": "physiology_cellml_obeyesekere_zimmerman_tecarro_auchmuty_1999_obeyesekerezimmermantecarroauchmuty1999_model.summary"
    },
    {
      "to": [
        "visualisation.physiology_cellml_obeyesekere_zimmerman_tecarro_auchmuty_1999_obeyesekerezimmermantecarroauchmuty1999_model_trajectory"
      ],
      "from": "physiology_cellml_obeyesekere_zimmerman_tecarro_auchmuty_1999_obeyesekerezimmermantecarroauchmuty1999_model.trajectory"
    },
    {
      "to": [
        "visualisation.physiology_cellml_obeyesekere_zimmerman_tecarro_auchmuty_1999_obeyesekerezimmermantecarroauchmuty1999_model_variable_labels"
      ],
      "from": "physiology_cellml_obeyesekere_zimmerman_tecarro_auchmuty_1999_obeyesekerezimmermantecarroauchmuty1999_model.variable_labels"
    }
  ],
  "runtime": {
    "duration": 0.01,
    "settle_steps": 1,
    "initial_inputs": {},
    "communication_step": 0.01
  },
  "description": "Source-faithful physiology lab for Obeyesekere, Zimmerman, Tecarro, Auchmuty, 1999. Public controls and outputs are mapped to real source symbols for cell-cycle dynamics.",
  "schema_version": "2.0"
}