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Ledzewicz2013 - On optimal chemotherapy with a strongly targeted agent for a model of tumor immune system interactions with generalized logistic growth Lab

About lab

On optimal chemotherapy with a strongly targeted agent for a model of tumor-immune system interactions with generalized logistic growth.Ledzewicz U1, Olumoye O, Schättler H.1Dept. It can be used to explore immune response dynamics and compare pathway-level behavior across conditions.

Runtime

Duration10
Comms Step1

Runs

Total0
Completed0
Failed0

Metadata

Packageledzewicz2013-on-optimal-chemotherapy-with-a-strongly-targeted-a
Created2026-05-15
Updated2026-05-15
immunologysbmlbiomodels_ebifaithfulcuratedvisualisation

Manifest

{
  "io": {
    "inputs": [
      {
        "name": "initial_unresolved_tumor_observable_1",
        "label": "Initial Unresolved Tumor Observable 1",
        "units": "native source value",
        "default": 0.1,
        "maps_to": "immunology_sbml_ledzewicz2013_on_optimal_chemotherapy_with_a_str_biomd0000000919_model.initial_unresolved_tumor_observable_1",
        "description": "Initial Unresolved Tumor Observable 1. Sets the initial value of bundled SBML species `y`."
      },
      {
        "name": "initial_unresolved_tumor_observable_2",
        "label": "Initial Unresolved Tumor Observable 2",
        "units": "native source value",
        "default": 600,
        "maps_to": "immunology_sbml_ledzewicz2013_on_optimal_chemotherapy_with_a_str_biomd0000000919_model.initial_unresolved_tumor_observable_2",
        "description": "Initial Unresolved Tumor Observable 2. Sets the initial value of bundled SBML species `x`."
      },
      {
        "name": "a_constant_rate_of_influx_of_t_cells_generated_through_the_primary_organs_rate",
        "label": "A Constant Rate Of Influx Of T Cells Generated Through The Primary Organs Rate",
        "units": "native source value",
        "default": 0.1181,
        "maps_to": "immunology_sbml_ledzewicz2013_on_optimal_chemotherapy_with_a_str_biomd0000000919_model.a_constant_rate_of_influx_of_t_cells_generated_through_the_primary_organs_rate",
        "description": "A Constant Rate Of Influx Of T Cells Generated Through The Primary Organs Rate. Sets bundled SBML parameter `alpha`."
      },
      {
        "name": "natural_death_of_t_cells_rate",
        "label": "Natural Death Of T Cells Rate",
        "units": "native source value",
        "default": 0.37451,
        "maps_to": "immunology_sbml_ledzewicz2013_on_optimal_chemotherapy_with_a_str_biomd0000000919_model.natural_death_of_t_cells_rate",
        "description": "Natural Death Of T Cells Rate. Sets bundled SBML parameter `delta`."
      }
    ],
    "outputs": [
      {
        "name": "unresolved_tumor_observable_1",
        "maps_to": "immunology_sbml_ledzewicz2013_on_optimal_chemotherapy_with_a_str_biomd0000000919_model.unresolved_tumor_observable_1"
      },
      {
        "name": "unresolved_tumor_observable_2",
        "maps_to": "immunology_sbml_ledzewicz2013_on_optimal_chemotherapy_with_a_str_biomd0000000919_model.unresolved_tumor_observable_2"
      },
      {
        "name": "state",
        "maps_to": "immunology_sbml_ledzewicz2013_on_optimal_chemotherapy_with_a_str_biomd0000000919_model.state"
      },
      {
        "name": "summary",
        "maps_to": "immunology_sbml_ledzewicz2013_on_optimal_chemotherapy_with_a_str_biomd0000000919_model.summary"
      },
      {
        "name": "species_labels",
        "maps_to": "immunology_sbml_ledzewicz2013_on_optimal_chemotherapy_with_a_str_biomd0000000919_model.species_labels"
      }
    ]
  },
  "title": "Ledzewicz2013 - On optimal chemotherapy with a strongly targeted agent for a model of tumor immune system interactions with generalized logistic growth Lab",
  "models": [
    {
      "path": "owned/models/immunology_sbml_ledzewicz2013_on_optimal_chemotherapy_with_a_str_biomd0000000919_model",
      "alias": "immunology_sbml_ledzewicz2013_on_optimal_chemotherapy_with_a_str_biomd0000000919_model",
      "provenance": {
        "owned_path": "owned/models/immunology_sbml_ledzewicz2013_on_optimal_chemotherapy_with_a_str_biomd0000000919_model"
      }
    },
    {
      "path": "owned/models/visualisation",
      "alias": "visualisation",
      "provenance": {
        "owned_path": "owned/models/visualisation"
      }
    }
  ],
  "wiring": [
    {
      "to": [
        "visualisation.immunology_sbml_ledzewicz2013_on_optimal_chemotherapy_with_a_str_biomd0000000919_model_state"
      ],
      "from": "immunology_sbml_ledzewicz2013_on_optimal_chemotherapy_with_a_str_biomd0000000919_model.state"
    },
    {
      "to": [
        "visualisation.immunology_sbml_ledzewicz2013_on_optimal_chemotherapy_with_a_str_biomd0000000919_model_summary"
      ],
      "from": "immunology_sbml_ledzewicz2013_on_optimal_chemotherapy_with_a_str_biomd0000000919_model.summary"
    },
    {
      "to": [
        "visualisation.immunology_sbml_ledzewicz2013_on_optimal_chemotherapy_with_a_str_biomd0000000919_model_species_labels"
      ],
      "from": "immunology_sbml_ledzewicz2013_on_optimal_chemotherapy_with_a_str_biomd0000000919_model.species_labels"
    }
  ],
  "runtime": {
    "duration": 10,
    "initial_inputs": {},
    "communication_step": 1
  },
  "description": "On optimal chemotherapy with a strongly targeted agent for a model of tumor-immune system interactions with generalized logistic growth.Ledzewicz U1, Olumoye O, Schättler H.1Dept. It can be used to explore immune response dynamics and compare pathway-level behavior across conditions.",
  "schema_version": "2.0"
}

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