Shi1993_Caffeine_pressor_tolerance Lab

{
  "io": {
    "inputs": [
      {
        "name": "initial_gut_caffeine_amount",
        "label": "Initial Gut Caffeine Amount",
        "maps_to": "pharmacology_sbml_shi1993_caffeine_pressor_tolerance_biomd0000000241_model.initial_gut_caffeine_amount"
      },
      {
        "name": "initial_plasma_caffeine_concentration",
        "label": "Initial Plasma Caffeine Concentration",
        "maps_to": "pharmacology_sbml_shi1993_caffeine_pressor_tolerance_biomd0000000241_model.initial_plasma_caffeine_concentration"
      },
      {
        "name": "initial_effect_site_caffeine",
        "label": "Initial Effect Site Caffeine",
        "maps_to": "pharmacology_sbml_shi1993_caffeine_pressor_tolerance_biomd0000000241_model.initial_effect_site_caffeine"
      },
      {
        "name": "initial_tolerance_state",
        "label": "Initial Tolerance State",
        "maps_to": "pharmacology_sbml_shi1993_caffeine_pressor_tolerance_biomd0000000241_model.initial_tolerance_state"
      }
    ],
    "outputs": [
      {
        "name": "state",
        "label": "Tracked source state",
        "maps_to": "pharmacology_sbml_shi1993_caffeine_pressor_tolerance_biomd0000000241_model.state"
      },
      {
        "name": "summary",
        "label": "Simulation summary",
        "maps_to": "pharmacology_sbml_shi1993_caffeine_pressor_tolerance_biomd0000000241_model.summary"
      },
      {
        "name": "species_labels",
        "label": "Observable labels",
        "maps_to": "pharmacology_sbml_shi1993_caffeine_pressor_tolerance_biomd0000000241_model.species_labels"
      },
      {
        "name": "gut_caffeine_amount",
        "label": "Gut Caffeine Amount",
        "maps_to": "pharmacology_sbml_shi1993_caffeine_pressor_tolerance_biomd0000000241_model.gut_caffeine_amount"
      },
      {
        "name": "plasma_caffeine_concentration",
        "label": "Plasma Caffeine Concentration",
        "maps_to": "pharmacology_sbml_shi1993_caffeine_pressor_tolerance_biomd0000000241_model.plasma_caffeine_concentration"
      },
      {
        "name": "peripheral_caffeine_concentration",
        "label": "Peripheral Caffeine Concentration",
        "maps_to": "pharmacology_sbml_shi1993_caffeine_pressor_tolerance_biomd0000000241_model.peripheral_caffeine_concentration"
      },
      {
        "name": "effect_site_caffeine_concentration",
        "label": "Effect Site Caffeine Concentration",
        "maps_to": "pharmacology_sbml_shi1993_caffeine_pressor_tolerance_biomd0000000241_model.effect_site_caffeine_concentration"
      },
      {
        "name": "tolerance_state",
        "label": "Tolerance State",
        "maps_to": "pharmacology_sbml_shi1993_caffeine_pressor_tolerance_biomd0000000241_model.tolerance_state"
      }
    ]
  },
  "tags": [
    "pharmacology",
    "pharmacodynamics",
    "cardiovascular",
    "physiology",
    "tolerance",
    "sbml",
    "tellurium",
    "faithful",
    "biomodels_ebi"
  ],
  "title": "Shi1993_Caffeine_pressor_tolerance Lab",
  "models": [
    {
      "path": "owned/models/pharmacology_sbml_shi1993_caffeine_pressor_tolerance_biomd0000000241_model",
      "alias": "pharmacology_sbml_shi1993_caffeine_pressor_tolerance_biomd0000000241_model",
      "parameters": {
        "model_path": "data/BIOMD0000000241.xml",
        "integration_step": 0.2
      },
      "provenance": {
        "owned_path": "owned/models/pharmacology_sbml_shi1993_caffeine_pressor_tolerance_biomd0000000241_model"
      }
    },
    {
      "path": "owned/models/visualisation",
      "alias": "visualisation",
      "provenance": {
        "owned_path": "owned/models/visualisation"
      }
    }
  ],
  "wiring": [
    {
      "to": [
        "visualisation.pharmacology_sbml_shi1993_caffeine_pressor_tolerance_biomd0000000241_model_state"
      ],
      "from": "pharmacology_sbml_shi1993_caffeine_pressor_tolerance_biomd0000000241_model.state"
    },
    {
      "to": [
        "visualisation.pharmacology_sbml_shi1993_caffeine_pressor_tolerance_biomd0000000241_model_summary"
      ],
      "from": "pharmacology_sbml_shi1993_caffeine_pressor_tolerance_biomd0000000241_model.summary"
    },
    {
      "to": [
        "visualisation.pharmacology_sbml_shi1993_caffeine_pressor_tolerance_biomd0000000241_model_species_labels"
      ],
      "from": "pharmacology_sbml_shi1993_caffeine_pressor_tolerance_biomd0000000241_model.species_labels"
    }
  ],
  "runtime": {
    "duration": 60,
    "initial_inputs": {},
    "communication_step": 2
  },
  "description": "described in: Pharmacokinetic-pharmacodynamic modeling of caffeine: Tolerance to pressor effects Shi J, Benowitz NL, Denaro CP and Sheiner LB. It can be used to explore dose-response dynamics and compare treatment scenarios across conditions.",
  "schema_version": "2.0"
}