Gerard2010 - Progression of mammalian cell cycle by successive activation of various cyclin cdk complexes Lab

{
  "io": {
    "inputs": [
      {
        "name": "growth_factor",
        "label": "Growth Factor",
        "maps_to": "cellcycle_sbml_gerard2010_progression_of_mammalian_cell_cycle_b_biomd0000000941_model.growth_factor",
        "description": "Controls Growth Factor in the lab model via `cellcycle_sbml_gerard2010_progression_of_mammalian_cell_cycle_b_biomd0000000941_model.growth_factor`."
      },
      {
        "name": "kgf",
        "label": "Kgf",
        "maps_to": "cellcycle_sbml_gerard2010_progression_of_mammalian_cell_cycle_b_biomd0000000941_model.kgf",
        "description": "Controls Kgf in the lab model via `cellcycle_sbml_gerard2010_progression_of_mammalian_cell_cycle_b_biomd0000000941_model.kgf`."
      }
    ],
    "outputs": [
      {
        "name": "cyclin_d_cdk4_6",
        "label": "Cyclin D CDK4 6",
        "maps_to": "cellcycle_sbml_gerard2010_progression_of_mammalian_cell_cycle_b_biomd0000000941_model.cyclin_d_cdk4_6",
        "description": "Tracks Cyclin D CDK4 6 in the lab model via `cellcycle_sbml_gerard2010_progression_of_mammalian_cell_cycle_b_biomd0000000941_model.cyclin_d_cdk4_6`."
      },
      {
        "name": "transcription_factor_e2f_active",
        "label": "Transcription Factor E2F Active",
        "maps_to": "cellcycle_sbml_gerard2010_progression_of_mammalian_cell_cycle_b_biomd0000000941_model.transcription_factor_e2f_active",
        "description": "Tracks Transcription Factor E2F Active in the lab model via `cellcycle_sbml_gerard2010_progression_of_mammalian_cell_cycle_b_biomd0000000941_model.transcription_factor_e2f_active`."
      },
      {
        "name": "cyclin_e_cdk2",
        "label": "Cyclin E CDK2",
        "maps_to": "cellcycle_sbml_gerard2010_progression_of_mammalian_cell_cycle_b_biomd0000000941_model.cyclin_e_cdk2",
        "description": "Tracks Cyclin E CDK2 in the lab model via `cellcycle_sbml_gerard2010_progression_of_mammalian_cell_cycle_b_biomd0000000941_model.cyclin_e_cdk2`."
      },
      {
        "name": "cyclin_active_cdk2",
        "label": "Cyclin Active CDK2",
        "maps_to": "cellcycle_sbml_gerard2010_progression_of_mammalian_cell_cycle_b_biomd0000000941_model.cyclin_active_cdk2",
        "description": "Tracks Cyclin Active CDK2 in the lab model via `cellcycle_sbml_gerard2010_progression_of_mammalian_cell_cycle_b_biomd0000000941_model.cyclin_active_cdk2`."
      },
      {
        "name": "cyclin_b_cdk1",
        "label": "Cyclin B CDK1",
        "maps_to": "cellcycle_sbml_gerard2010_progression_of_mammalian_cell_cycle_b_biomd0000000941_model.cyclin_b_cdk1",
        "description": "Tracks Cyclin B CDK1 in the lab model via `cellcycle_sbml_gerard2010_progression_of_mammalian_cell_cycle_b_biomd0000000941_model.cyclin_b_cdk1`."
      },
      {
        "name": "cdc20_active",
        "label": "Cdc20 Active",
        "maps_to": "cellcycle_sbml_gerard2010_progression_of_mammalian_cell_cycle_b_biomd0000000941_model.cdc20_active",
        "description": "Tracks Cdc20 Active in the lab model via `cellcycle_sbml_gerard2010_progression_of_mammalian_cell_cycle_b_biomd0000000941_model.cdc20_active`."
      },
      {
        "name": "e2f_total",
        "label": "E2F Total",
        "maps_to": "cellcycle_sbml_gerard2010_progression_of_mammalian_cell_cycle_b_biomd0000000941_model.e2f_total",
        "description": "Tracks E2F Total in the lab model via `cellcycle_sbml_gerard2010_progression_of_mammalian_cell_cycle_b_biomd0000000941_model.e2f_total`."
      },
      {
        "name": "cdc20_total",
        "label": "Cdc20 Total",
        "maps_to": "cellcycle_sbml_gerard2010_progression_of_mammalian_cell_cycle_b_biomd0000000941_model.cdc20_total",
        "description": "Tracks Cdc20 Total in the lab model via `cellcycle_sbml_gerard2010_progression_of_mammalian_cell_cycle_b_biomd0000000941_model.cdc20_total`."
      }
    ]
  },
  "title": "Gerard2010 - Progression of mammalian cell cycle by successive activation of various cyclin cdk complexes Lab",
  "models": [
    {
      "path": "models/core",
      "alias": "cellcycle_sbml_gerard2010_progression_of_mammalian_cell_cycle_b_biomd0000000941_model"
    },
    {
      "path": "models/visualisation",
      "alias": "visualisation"
    }
  ],
  "wiring": [
    {
      "to": [
        "visualisation.cellcycle_sbml_gerard2010_progression_of_mammalian_cell_cycle_b_biomd0000000941_model_state"
      ],
      "from": "cellcycle_sbml_gerard2010_progression_of_mammalian_cell_cycle_b_biomd0000000941_model.state"
    },
    {
      "to": [
        "visualisation.cellcycle_sbml_gerard2010_progression_of_mammalian_cell_cycle_b_biomd0000000941_model_summary"
      ],
      "from": "cellcycle_sbml_gerard2010_progression_of_mammalian_cell_cycle_b_biomd0000000941_model.summary"
    },
    {
      "to": [
        "visualisation.cellcycle_sbml_gerard2010_progression_of_mammalian_cell_cycle_b_biomd0000000941_model_species_labels"
      ],
      "from": "cellcycle_sbml_gerard2010_progression_of_mammalian_cell_cycle_b_biomd0000000941_model.species_labels"
    }
  ],
  "package": "gerard2010-cyclin-cdk-progression",
  "runtime": {
    "duration": 10,
    "initial_inputs": {},
    "communication_step": 1
  },
  "version": "1.0.0",
  "description": "Single-model lab wrapper for Gerard2010 - Progression of mammalian cell cycle by successive activation of various cyclin cdk complexes. We previously proposed a detailed, 39-variable model for the network of cyclin-dependent kinases (Cdks) that controls progression along the successive phases of the mammalian cell cycle. It can be used to explore cell-cycle regulation dynamics and compare checkpoint behavior across conditions.",
  "schema_version": "2.0"
}