Grzegorzewski2022 - PBPK model of dextromethorphan Lab

{
  "io": {
    "inputs": [
      {
        "name": "oral_dextromethorphan_dose_mg",
        "label": "Oral Dextromethorphan Dose Mg",
        "maps_to": "pharmacology_sbml_grzegorzewski2022_pbpk_model_of_dextromethorphan_model2301090002_model.oral_dextromethorphan_dose_mg"
      },
      {
        "name": "iv_dextromethorphan_bolus_mg",
        "label": "IV Dextromethorphan Bolus Mg",
        "maps_to": "pharmacology_sbml_grzegorzewski2022_pbpk_model_of_dextromethorphan_model2301090002_model.iv_dextromethorphan_bolus_mg"
      },
      {
        "name": "dextromethorphan_infusion_rate_mg_per_min",
        "label": "Dextromethorphan Infusion Rate Mg Per Min",
        "maps_to": "pharmacology_sbml_grzegorzewski2022_pbpk_model_of_dextromethorphan_model2301090002_model.dextromethorphan_infusion_rate_mg_per_min"
      },
      {
        "name": "cyp2d6_custom_activity",
        "label": "CYP2D6 Custom Activity",
        "maps_to": "pharmacology_sbml_grzegorzewski2022_pbpk_model_of_dextromethorphan_model2301090002_model.cyp2d6_custom_activity"
      },
      {
        "name": "cyp2d6_vmax",
        "label": "CYP2D6 VMAX",
        "maps_to": "pharmacology_sbml_grzegorzewski2022_pbpk_model_of_dextromethorphan_model2301090002_model.cyp2d6_vmax"
      },
      {
        "name": "cyp3a4_vmax",
        "label": "CYP3A4 VMAX",
        "maps_to": "pharmacology_sbml_grzegorzewski2022_pbpk_model_of_dextromethorphan_model2301090002_model.cyp3a4_vmax"
      }
    ],
    "outputs": [
      {
        "name": "state",
        "label": "Tracked source state",
        "maps_to": "pharmacology_sbml_grzegorzewski2022_pbpk_model_of_dextromethorphan_model2301090002_model.state"
      },
      {
        "name": "summary",
        "label": "Simulation summary",
        "maps_to": "pharmacology_sbml_grzegorzewski2022_pbpk_model_of_dextromethorphan_model2301090002_model.summary"
      },
      {
        "name": "species_labels",
        "label": "Observable labels",
        "maps_to": "pharmacology_sbml_grzegorzewski2022_pbpk_model_of_dextromethorphan_model2301090002_model.species_labels"
      },
      {
        "name": "dextromethorphan_liver_plasma",
        "label": "Dextromethorphan Liver Plasma",
        "maps_to": "pharmacology_sbml_grzegorzewski2022_pbpk_model_of_dextromethorphan_model2301090002_model.dextromethorphan_liver_plasma"
      },
      {
        "name": "dextromethorphan_gut_plasma",
        "label": "Dextromethorphan Gut Plasma",
        "maps_to": "pharmacology_sbml_grzegorzewski2022_pbpk_model_of_dextromethorphan_model2301090002_model.dextromethorphan_gut_plasma"
      },
      {
        "name": "dextromethorphan_kidney_plasma",
        "label": "Dextromethorphan Kidney Plasma",
        "maps_to": "pharmacology_sbml_grzegorzewski2022_pbpk_model_of_dextromethorphan_model2301090002_model.dextromethorphan_kidney_plasma"
      },
      {
        "name": "dextromethorphan_lung_plasma",
        "label": "Dextromethorphan Lung Plasma",
        "maps_to": "pharmacology_sbml_grzegorzewski2022_pbpk_model_of_dextromethorphan_model2301090002_model.dextromethorphan_lung_plasma"
      },
      {
        "name": "dextorphan_liver_plasma",
        "label": "Dextorphan Liver Plasma",
        "maps_to": "pharmacology_sbml_grzegorzewski2022_pbpk_model_of_dextromethorphan_model2301090002_model.dextorphan_liver_plasma"
      },
      {
        "name": "dextorphan_glucuronide_liver_plasma",
        "label": "Dextorphan Glucuronide Liver Plasma",
        "maps_to": "pharmacology_sbml_grzegorzewski2022_pbpk_model_of_dextromethorphan_model2301090002_model.dextorphan_glucuronide_liver_plasma"
      }
    ]
  },
  "tags": [
    "pharmacology",
    "pbpk",
    "pharmacokinetics",
    "physiology",
    "cyp-metabolism",
    "sbml",
    "tellurium",
    "faithful",
    "biomodels_ebi"
  ],
  "title": "Grzegorzewski2022 - PBPK model of dextromethorphan Lab",
  "models": [
    {
      "path": "models/core",
      "alias": "pharmacology_sbml_grzegorzewski2022_pbpk_model_of_dextromethorphan_model2301090002_model",
      "parameters": {
        "model_path": "data/MODEL2301090002.xml",
        "integration_step": 0.1
      }
    },
    {
      "path": "models/visualisation",
      "alias": "visualisation"
    }
  ],
  "wiring": [
    {
      "to": [
        "visualisation.pharmacology_sbml_grzegorzewski2022_pbpk_model_of_dextromethorphan_model2301090002_model_state"
      ],
      "from": "pharmacology_sbml_grzegorzewski2022_pbpk_model_of_dextromethorphan_model2301090002_model.state"
    },
    {
      "to": [
        "visualisation.pharmacology_sbml_grzegorzewski2022_pbpk_model_of_dextromethorphan_model2301090002_model_summary"
      ],
      "from": "pharmacology_sbml_grzegorzewski2022_pbpk_model_of_dextromethorphan_model2301090002_model.summary"
    },
    {
      "to": [
        "visualisation.pharmacology_sbml_grzegorzewski2022_pbpk_model_of_dextromethorphan_model2301090002_model_species_labels"
      ],
      "from": "pharmacology_sbml_grzegorzewski2022_pbpk_model_of_dextromethorphan_model2301090002_model.species_labels"
    }
  ],
  "package": "grzegorzewski2022-dextromethorphan-pbpk",
  "runtime": {
    "duration": 24,
    "initial_inputs": {},
    "communication_step": 1
  },
  "version": "1.0.0",
  "description": "Physiologically based pharmacokinetic (PBPK) modeling of the role of CYP2D6 polymorphism for metabolic phenotyping with dextromethorphan. It can be used to explore dose-response dynamics and compare treatment scenarios across conditions.",
  "schema_version": "2.0"
}