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Singh2006_TCA_mtu_model2 Lab

About lab

This a model from the article: Kinetic modeling of tricarboxylic acid cycle and glyoxylate bypass in Mycobacterium tuberculosis, and its application to assessment of drug targets. It can be used to explore dose-response dynamics and compare treatment scenarios across conditions.

Runtime

Duration5
Comms Step0.5

Runs

Total0
Completed0
Failed0

Metadata

Packagesingh2006-tca-mtu-model2-lab
Created2026-05-16
Updated2026-05-16
pharmacologyantimicrobialtuberculosismetabolismsbmltelluriumfaithfulbiomodels_ebivisualisation

Manifest

{
  "io": {
    "inputs": [
      {
        "name": "initial_coa_pool",
        "label": "Initial Coa Pool",
        "maps_to": "pharmacology_sbml_singh2006_tca_mtu_model2_biomd0000000218_model.initial_coa_pool"
      },
      {
        "name": "initial_acetate_or_acetyl_pool",
        "label": "Initial Acetate Or Acetyl Pool",
        "maps_to": "pharmacology_sbml_singh2006_tca_mtu_model2_biomd0000000218_model.initial_acetate_or_acetyl_pool"
      },
      {
        "name": "initial_oxaloacetate_pool",
        "label": "Initial Oxaloacetate Pool",
        "maps_to": "pharmacology_sbml_singh2006_tca_mtu_model2_biomd0000000218_model.initial_oxaloacetate_pool"
      },
      {
        "name": "initial_citrate_pool",
        "label": "Initial Citrate Pool",
        "maps_to": "pharmacology_sbml_singh2006_tca_mtu_model2_biomd0000000218_model.initial_citrate_pool"
      }
    ],
    "outputs": [
      {
        "name": "state",
        "label": "Tracked source state",
        "maps_to": "pharmacology_sbml_singh2006_tca_mtu_model2_biomd0000000218_model.state"
      },
      {
        "name": "summary",
        "label": "Simulation summary",
        "maps_to": "pharmacology_sbml_singh2006_tca_mtu_model2_biomd0000000218_model.summary"
      },
      {
        "name": "species_labels",
        "label": "Observable labels",
        "maps_to": "pharmacology_sbml_singh2006_tca_mtu_model2_biomd0000000218_model.species_labels"
      },
      {
        "name": "coa_pool",
        "label": "Coa Pool",
        "maps_to": "pharmacology_sbml_singh2006_tca_mtu_model2_biomd0000000218_model.coa_pool"
      },
      {
        "name": "acetate_or_acetyl_pool",
        "label": "Acetate Or Acetyl Pool",
        "maps_to": "pharmacology_sbml_singh2006_tca_mtu_model2_biomd0000000218_model.acetate_or_acetyl_pool"
      },
      {
        "name": "oxaloacetate_pool",
        "label": "Oxaloacetate Pool",
        "maps_to": "pharmacology_sbml_singh2006_tca_mtu_model2_biomd0000000218_model.oxaloacetate_pool"
      },
      {
        "name": "citrate_pool",
        "label": "Citrate Pool",
        "maps_to": "pharmacology_sbml_singh2006_tca_mtu_model2_biomd0000000218_model.citrate_pool"
      },
      {
        "name": "isocitrate_pool",
        "label": "Isocitrate Pool",
        "maps_to": "pharmacology_sbml_singh2006_tca_mtu_model2_biomd0000000218_model.isocitrate_pool"
      },
      {
        "name": "alpha_ketoglutarate_pool",
        "label": "Alpha Ketoglutarate Pool",
        "maps_to": "pharmacology_sbml_singh2006_tca_mtu_model2_biomd0000000218_model.alpha_ketoglutarate_pool"
      },
      {
        "name": "succinate_semialdehyde_pool",
        "label": "Succinate Semialdehyde Pool",
        "maps_to": "pharmacology_sbml_singh2006_tca_mtu_model2_biomd0000000218_model.succinate_semialdehyde_pool"
      },
      {
        "name": "succinate_pool",
        "label": "Succinate Pool",
        "maps_to": "pharmacology_sbml_singh2006_tca_mtu_model2_biomd0000000218_model.succinate_pool"
      }
    ]
  },
  "tags": [
    "pharmacology",
    "antimicrobial",
    "tuberculosis",
    "metabolism",
    "sbml",
    "tellurium",
    "faithful",
    "biomodels_ebi"
  ],
  "title": "Singh2006_TCA_mtu_model2 Lab",
  "models": [
    {
      "path": "owned/models/pharmacology_sbml_singh2006_tca_mtu_model2_biomd0000000218_model",
      "alias": "pharmacology_sbml_singh2006_tca_mtu_model2_biomd0000000218_model",
      "parameters": {
        "model_path": "data/BIOMD0000000218.xml",
        "integration_step": 0.05
      },
      "provenance": {
        "owned_path": "owned/models/pharmacology_sbml_singh2006_tca_mtu_model2_biomd0000000218_model"
      }
    },
    {
      "path": "owned/models/visualisation",
      "alias": "visualisation",
      "provenance": {
        "owned_path": "owned/models/visualisation"
      }
    }
  ],
  "wiring": [
    {
      "to": [
        "visualisation.pharmacology_sbml_singh2006_tca_mtu_model2_biomd0000000218_model_state"
      ],
      "from": "pharmacology_sbml_singh2006_tca_mtu_model2_biomd0000000218_model.state"
    },
    {
      "to": [
        "visualisation.pharmacology_sbml_singh2006_tca_mtu_model2_biomd0000000218_model_summary"
      ],
      "from": "pharmacology_sbml_singh2006_tca_mtu_model2_biomd0000000218_model.summary"
    },
    {
      "to": [
        "visualisation.pharmacology_sbml_singh2006_tca_mtu_model2_biomd0000000218_model_species_labels"
      ],
      "from": "pharmacology_sbml_singh2006_tca_mtu_model2_biomd0000000218_model.species_labels"
    }
  ],
  "runtime": {
    "duration": 5,
    "initial_inputs": {},
    "communication_step": 0.5
  },
  "description": "This a model from the article: Kinetic modeling of tricarboxylic acid cycle and glyoxylate bypass in Mycobacterium tuberculosis, and its application to assessment of drug targets. It can be used to explore dose-response dynamics and compare treatment scenarios across conditions.",
  "schema_version": "2.0"
}

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