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Adams2003 Thrombin Inhibitors Lab

About lab

Adams2003 Thrombin Inhibitors

This Biosimulant lab wraps Adams2003 Thrombin Inhibitors as a runnable systems biology model with a companion visualization module. Mathematical model of blood coagulation. It can be used to explore the configured dynamics and compare scenario outcomes across configurations.

What You'll See

The lab asks: Which drug, dose, or target-linked model states drive the simulated profile? Source model: Adams2003 - Thrombin Inhibitors. It runs for 1.0 time units with a communication step of 0.1. The run uses the model defaults declared by the curated SBML wrapper. The generated visualizations focus on mIIa_ATIII, mIIa, Xa_Va_II, Xa_Va, Xa_TFPI, and Xa_ATIII, combining trajectory, endpoint-comparison, and summary-table views from one completed dark-mode run.

In this captured run, Xa_ATIII moved from 0 to 1.65e-17 across 1.0 simulation windows.

Output Visualizations

Adams2003 Thrombin Inhibitors - run interpretation

Summary table for Adams2003 Thrombin Inhibitors, reporting the scientific question, observed answer, dominant module, and caveat.

Adams2003 Thrombin Inhibitors - timeseries visualization

Trajectories of Xa_ATIII, Xa_TFPI, mIIa, Xa_Va, Xa_Va_II, and mIIa_ATIII across the 1.0 simulation. In this run Xa_ATIII climbed from 0 to 1.65e-17 — the largest movements among the focused observables.

Adams2003 Thrombin Inhibitors - excursions bar

Largest-excursion ranking of the focused observables — the absolute movement magnitude during the run. Top 3: Xa_ATIII = 1.65e-17, Xa_TFPI = 7.29e-18, mIIa = 4.61e-24, with 3 more observables below.

Adams2003 Thrombin Inhibitors - endpoint snapshot bar

Endpoint snapshot of the focused observables — final values from the captured run. Top 3 by value: Xa_ATIII = 1.65e-17, Xa_TFPI = 7.29e-18, mIIa = 4.61e-24, with 3 more observables below.

Adams2003 Thrombin Inhibitors - visualization

Visualization card from the Adams2003 Thrombin Inhibitors dark-mode run.

Model Context

  • Core model: models/core
  • Visualization model: models/visualisation
  • Standard: other
  • Upstream source: biomodels_ebi:MODEL1808150002
  • License: CC0

Inputs

InputMaps ToDefaultNotes
Initial M I Ia Atiiisystemsbiology_sbml_adams2003_thrombin_inhibitors_model1808150002_model.initial_m_i_ia_atiiiSource state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol mIIa_ATIII.
Initial M I Iasystemsbiology_sbml_adams2003_thrombin_inhibitors_model1808150002_model.initial_m_i_iaSource state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol mIIa.
Initial Xa Va Iisystemsbiology_sbml_adams2003_thrombin_inhibitors_model1808150002_model.initial_xa_va_iiSource state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol Xa_Va_II.
Initial Xa Vasystemsbiology_sbml_adams2003_thrombin_inhibitors_model1808150002_model.initial_xa_vaSource state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol Xa_Va.
Initial Xa Tfpisystemsbiology_sbml_adams2003_thrombin_inhibitors_model1808150002_model.initial_xa_tfpiSource state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol Xa_TFPI.
Initial Xa Atiiisystemsbiology_sbml_adams2003_thrombin_inhibitors_model1808150002_model.initial_xa_atiiiSource state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol Xa_ATIII.

Outputs

OutputMaps ToRole
statesystemsbiology_sbml_adams2003_thrombin_inhibitors_model1808150002_model.stateAvailable to the visualization model and downstream workflows.
summarysystemsbiology_sbml_adams2003_thrombin_inhibitors_model1808150002_model.summaryAvailable to the visualization model and downstream workflows.
species_labelssystemsbiology_sbml_adams2003_thrombin_inhibitors_model1808150002_model.species_labelsAvailable to the visualization model and downstream workflows.
m_i_ia_atiiisystemsbiology_sbml_adams2003_thrombin_inhibitors_model1808150002_model.m_i_ia_atiiiAvailable to the visualization model and downstream workflows.
m_i_iasystemsbiology_sbml_adams2003_thrombin_inhibitors_model1808150002_model.m_i_iaAvailable to the visualization model and downstream workflows.
xa_va_iisystemsbiology_sbml_adams2003_thrombin_inhibitors_model1808150002_model.xa_va_iiAvailable to the visualization model and downstream workflows.
xa_vasystemsbiology_sbml_adams2003_thrombin_inhibitors_model1808150002_model.xa_vaAvailable to the visualization model and downstream workflows.
xa_tfpisystemsbiology_sbml_adams2003_thrombin_inhibitors_model1808150002_model.xa_tfpiAvailable to the visualization model and downstream workflows.
xa_atiiisystemsbiology_sbml_adams2003_thrombin_inhibitors_model1808150002_model.xa_atiiiAvailable to the visualization model and downstream workflows.

Runtime

  • Duration: 1.0
  • Communication step: 0.1

Running Locally

biosimulant labs serve

Mathematical model of blood coagulation. It can be used to explore systemsbiology adams2003 thrombin inhibitors model1808150002 dynamics and compare simulation behavior across conditions.

Runtime

Duration1
Comms Step0.1

Runs

Total0
Completed0
Failed0

Metadata

Packageadams2003-thrombin-inhibitors-lab
Created2026-05-17
Updated2026-05-17
pharmacologysystemsbiologysbmlbiomodels_ebifaithfulcuratedvisualisation

Manifest

{
  "io": {
    "inputs": [
      {
        "name": "initial_m_i_ia_atiii",
        "label": "Initial M I Ia Atiii",
        "maps_to": "systemsbiology_sbml_adams2003_thrombin_inhibitors_model1808150002_model.initial_m_i_ia_atiii",
        "description": "Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol `mIIa_ATIII`."
      },
      {
        "name": "initial_m_i_ia",
        "label": "Initial M I Ia",
        "maps_to": "systemsbiology_sbml_adams2003_thrombin_inhibitors_model1808150002_model.initial_m_i_ia",
        "description": "Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol `mIIa`."
      },
      {
        "name": "initial_xa_va_ii",
        "label": "Initial Xa Va Ii",
        "maps_to": "systemsbiology_sbml_adams2003_thrombin_inhibitors_model1808150002_model.initial_xa_va_ii",
        "description": "Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol `Xa_Va_II`."
      },
      {
        "name": "initial_xa_va",
        "label": "Initial Xa Va",
        "maps_to": "systemsbiology_sbml_adams2003_thrombin_inhibitors_model1808150002_model.initial_xa_va",
        "description": "Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol `Xa_Va`."
      },
      {
        "name": "initial_xa_tfpi",
        "label": "Initial Xa Tfpi",
        "maps_to": "systemsbiology_sbml_adams2003_thrombin_inhibitors_model1808150002_model.initial_xa_tfpi",
        "description": "Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol `Xa_TFPI`."
      },
      {
        "name": "initial_xa_atiii",
        "label": "Initial Xa Atiii",
        "maps_to": "systemsbiology_sbml_adams2003_thrombin_inhibitors_model1808150002_model.initial_xa_atiii",
        "description": "Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol `Xa_ATIII`."
      }
    ],
    "outputs": [
      {
        "name": "state",
        "maps_to": "systemsbiology_sbml_adams2003_thrombin_inhibitors_model1808150002_model.state"
      },
      {
        "name": "summary",
        "maps_to": "systemsbiology_sbml_adams2003_thrombin_inhibitors_model1808150002_model.summary"
      },
      {
        "name": "species_labels",
        "maps_to": "systemsbiology_sbml_adams2003_thrombin_inhibitors_model1808150002_model.species_labels"
      },
      {
        "name": "m_i_ia_atiii",
        "maps_to": "systemsbiology_sbml_adams2003_thrombin_inhibitors_model1808150002_model.m_i_ia_atiii"
      },
      {
        "name": "m_i_ia",
        "maps_to": "systemsbiology_sbml_adams2003_thrombin_inhibitors_model1808150002_model.m_i_ia"
      },
      {
        "name": "xa_va_ii",
        "maps_to": "systemsbiology_sbml_adams2003_thrombin_inhibitors_model1808150002_model.xa_va_ii"
      },
      {
        "name": "xa_va",
        "maps_to": "systemsbiology_sbml_adams2003_thrombin_inhibitors_model1808150002_model.xa_va"
      },
      {
        "name": "xa_tfpi",
        "maps_to": "systemsbiology_sbml_adams2003_thrombin_inhibitors_model1808150002_model.xa_tfpi"
      },
      {
        "name": "xa_atiii",
        "maps_to": "systemsbiology_sbml_adams2003_thrombin_inhibitors_model1808150002_model.xa_atiii"
      }
    ]
  },
  "tags": [
    "pharmacology",
    "systemsbiology",
    "sbml",
    "biomodels_ebi",
    "faithful",
    "curated"
  ],
  "title": "Adams2003 Thrombin Inhibitors Lab",
  "models": [
    {
      "path": "owned/models/systemsbiology_sbml_adams2003_thrombin_inhibitors_model1808150002_model",
      "alias": "systemsbiology_sbml_adams2003_thrombin_inhibitors_model1808150002_model",
      "provenance": {
        "owned_path": "owned/models/systemsbiology_sbml_adams2003_thrombin_inhibitors_model1808150002_model"
      }
    },
    {
      "path": "owned/models/visualisation",
      "alias": "visualisation",
      "provenance": {
        "owned_path": "owned/models/visualisation"
      }
    }
  ],
  "wiring": [
    {
      "to": [
        "visualisation.systemsbiology_sbml_adams2003_thrombin_inhibitors_model1808150002_model_state"
      ],
      "from": "systemsbiology_sbml_adams2003_thrombin_inhibitors_model1808150002_model.state"
    },
    {
      "to": [
        "visualisation.systemsbiology_sbml_adams2003_thrombin_inhibitors_model1808150002_model_summary"
      ],
      "from": "systemsbiology_sbml_adams2003_thrombin_inhibitors_model1808150002_model.summary"
    },
    {
      "to": [
        "visualisation.systemsbiology_sbml_adams2003_thrombin_inhibitors_model1808150002_model_species_labels"
      ],
      "from": "systemsbiology_sbml_adams2003_thrombin_inhibitors_model1808150002_model.species_labels"
    }
  ],
  "runtime": {
    "duration": 1,
    "initial_inputs": {},
    "communication_step": 0.1
  },
  "description": "Mathematical model of blood coagulation. It can be used to explore systemsbiology adams2003 thrombin inhibitors model1808150002 dynamics and compare simulation behavior across conditions.",
  "schema_version": "2.0"
}

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