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Alexander2010 - Self Tolerance Autoimmunity Regulatory T Cell System 1 Lab

About lab

Source-faithful physiology lab for Alexander and Wahl 2010. Public controls and outputs are mapped to real source symbols for source-model physiology.

Runtime

Duration0.01
Comms Step0.01
Settle Steps1

Runs

Total0
Completed0
Failed0

Metadata

Packagealexander2010-self-tolerance-autoimmunity-regulatory-t-cell-syst
Created2026-05-23
Updated2026-05-23
physiologycellmlphysiomefaithfulvisualisationother

Manifest

{
  "io": {
    "inputs": [
      {
        "name": "initial_antigen",
        "label": "Initial Antigen",
        "maps_to": "physiology_cellml_alexander_and_wahl_2010_2d8_model.initial_antigen",
        "description": "Initial value for Antigen. Maps to source symbol `G`. Units: dimensionless. Naming evidence: source metadata names `G` as `antigen`.",
        "accepted_units": [
          "dimensionless"
        ]
      },
      {
        "name": "initial_effector_t_cells",
        "label": "Initial Effector T Cells",
        "maps_to": "physiology_cellml_alexander_and_wahl_2010_2d8_model.initial_effector_t_cells",
        "description": "Initial value for Effector T Cells. Maps to source symbol `E`. Units: dimensionless. Naming evidence: source metadata names `E` as `effector T cells`.",
        "accepted_units": [
          "dimensionless"
        ]
      }
    ],
    "outputs": [
      {
        "name": "state",
        "label": "Selected Source State",
        "maps_to": "physiology_cellml_alexander_and_wahl_2010_2d8_model.state"
      },
      {
        "name": "summary",
        "label": "Simulation Summary",
        "maps_to": "physiology_cellml_alexander_and_wahl_2010_2d8_model.summary"
      },
      {
        "name": "trajectory",
        "label": "Source Trajectory",
        "maps_to": "physiology_cellml_alexander_and_wahl_2010_2d8_model.trajectory"
      },
      {
        "name": "variable_labels",
        "label": "Observable Labels",
        "maps_to": "physiology_cellml_alexander_and_wahl_2010_2d8_model.variable_labels"
      },
      {
        "name": "antigen",
        "label": "Antigen",
        "maps_to": "physiology_cellml_alexander_and_wahl_2010_2d8_model.antigen",
        "description": "Antigen. Maps to source symbol `G`. Units: dimensionless. Naming evidence: source metadata names `G` as `antigen`."
      },
      {
        "name": "effector_t_cells",
        "label": "Effector T Cells",
        "maps_to": "physiology_cellml_alexander_and_wahl_2010_2d8_model.effector_t_cells",
        "description": "Effector T Cells. Maps to source symbol `E`. Units: dimensionless. Naming evidence: source metadata names `E` as `effector T cells`."
      },
      {
        "name": "regulatory_t_cells",
        "label": "Regulatory T Cells",
        "maps_to": "physiology_cellml_alexander_and_wahl_2010_2d8_model.regulatory_t_cells",
        "description": "Regulatory T Cells. Maps to source symbol `R`. Units: dimensionless. Naming evidence: source metadata names `R` as `regulatory T cells`."
      },
      {
        "name": "mature_antigen_presenting_cells",
        "label": "Mature Antigen Presenting Cells",
        "maps_to": "physiology_cellml_alexander_and_wahl_2010_2d8_model.mature_antigen_presenting_cells",
        "description": "Mature Antigen Presenting Cells. Maps to source symbol `A`. Units: dimensionless. Naming evidence: source metadata names `A` as `mature antigen presenting cells`."
      },
      {
        "name": "beta",
        "label": "Beta",
        "maps_to": "physiology_cellml_alexander_and_wahl_2010_2d8_model.beta",
        "description": "Beta. Maps to source symbol `beta`. Units: first_order_rate_constant. Naming evidence: source symbol, component, or units provide a direct public name."
      },
      {
        "name": "model_parameter_f",
        "label": "Model Parameter F (source f)",
        "maps_to": "physiology_cellml_alexander_and_wahl_2010_2d8_model.model_parameter_f",
        "description": "Model Parameter F (source f). Maps to source symbol `f`. Units: dimensionless. Naming evidence: source symbol is dimensionless but lacks enough evidence for a biological label."
      }
    ]
  },
  "title": "Alexander2010 - Self Tolerance Autoimmunity Regulatory T Cell System 1 Lab",
  "models": [
    {
      "path": "owned/models/physiology_cellml_alexander_and_wahl_2010_2d8_model",
      "alias": "physiology_cellml_alexander_and_wahl_2010_2d8_model",
      "parameters": {
        "model_path": "data/alexander_2010.cellml",
        "integration_step": 0.01
      },
      "provenance": {
        "owned_path": "owned/models/physiology_cellml_alexander_and_wahl_2010_2d8_model"
      }
    },
    {
      "path": "owned/models/visualisation",
      "alias": "visualisation",
      "provenance": {
        "owned_path": "owned/models/visualisation"
      }
    }
  ],
  "wiring": [
    {
      "to": [
        "visualisation.physiology_cellml_alexander_and_wahl_2010_2d8_model_state"
      ],
      "from": "physiology_cellml_alexander_and_wahl_2010_2d8_model.state"
    },
    {
      "to": [
        "visualisation.physiology_cellml_alexander_and_wahl_2010_2d8_model_summary"
      ],
      "from": "physiology_cellml_alexander_and_wahl_2010_2d8_model.summary"
    },
    {
      "to": [
        "visualisation.physiology_cellml_alexander_and_wahl_2010_2d8_model_trajectory"
      ],
      "from": "physiology_cellml_alexander_and_wahl_2010_2d8_model.trajectory"
    },
    {
      "to": [
        "visualisation.physiology_cellml_alexander_and_wahl_2010_2d8_model_variable_labels"
      ],
      "from": "physiology_cellml_alexander_and_wahl_2010_2d8_model.variable_labels"
    }
  ],
  "runtime": {
    "duration": 0.01,
    "settle_steps": 1,
    "initial_inputs": {},
    "communication_step": 0.01
  },
  "description": "Source-faithful physiology lab for Alexander and Wahl 2010. Public controls and outputs are mapped to real source symbols for source-model physiology.",
  "schema_version": "2.0"
}

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