Galante2012 - B7-H1 and a Mathematical Model for Cytotoxic T Cell and Tumor Cell Interaction Lab

{
  "io": {
    "inputs": [
      {
        "name": "initial_p_perforin",
        "label": "P Perforin",
        "units": "native SBML value",
        "default": 0.315,
        "maps_to": "oncology_sbml_galante2012_b7_h1_and_a_mathematical_model_for_c_biomd0000000812_model.initial_p_perforin",
        "description": "Initial P Perforin. Sets the initial value of bundled SBML symbol `P_Perforin`."
      },
      {
        "name": "initial_c_cancer_uncomplexed",
        "label": "C Cancer Uncomplexed",
        "units": "native SBML value",
        "default": 1,
        "maps_to": "oncology_sbml_galante2012_b7_h1_and_a_mathematical_model_for_c_biomd0000000812_model.initial_c_cancer_uncomplexed",
        "description": "Initial C Cancer Uncomplexed. Sets the initial value of bundled SBML symbol `C_Cancer_Uncomplexed`."
      },
      {
        "name": "initial_t_ast",
        "label": "T ast",
        "units": "native SBML value",
        "default": 1,
        "maps_to": "oncology_sbml_galante2012_b7_h1_and_a_mathematical_model_for_c_biomd0000000812_model.initial_t_ast",
        "description": "Initial T ast. Sets the initial value of bundled SBML symbol `T_ast`."
      },
      {
        "name": "initial_x_complex",
        "label": "X Complex",
        "units": "native SBML value",
        "default": 0,
        "maps_to": "oncology_sbml_galante2012_b7_h1_and_a_mathematical_model_for_c_biomd0000000812_model.initial_x_complex",
        "description": "Initial X Complex. Sets the initial value of bundled SBML symbol `X_Complex`."
      }
    ],
    "outputs": [
      {
        "name": "p_perforin",
        "maps_to": "oncology_sbml_galante2012_b7_h1_and_a_mathematical_model_for_c_biomd0000000812_model.p_perforin",
        "description": "P Perforin observable. Maps to SBML symbol `P_Perforin`."
      },
      {
        "name": "c_cancer_uncomplexed",
        "maps_to": "oncology_sbml_galante2012_b7_h1_and_a_mathematical_model_for_c_biomd0000000812_model.c_cancer_uncomplexed",
        "description": "C Cancer Uncomplexed observable. Maps to SBML symbol `C_Cancer_Uncomplexed`."
      },
      {
        "name": "t_ast",
        "maps_to": "oncology_sbml_galante2012_b7_h1_and_a_mathematical_model_for_c_biomd0000000812_model.t_ast",
        "description": "T ast observable. Maps to SBML symbol `T_ast`."
      },
      {
        "name": "x_complex",
        "maps_to": "oncology_sbml_galante2012_b7_h1_and_a_mathematical_model_for_c_biomd0000000812_model.x_complex",
        "description": "X Complex observable. Maps to SBML symbol `X_Complex`."
      },
      {
        "name": "state",
        "maps_to": "oncology_sbml_galante2012_b7_h1_and_a_mathematical_model_for_c_biomd0000000812_model.state",
        "description": "Full raw SBML observable record for reproducibility and downstream visualisation."
      },
      {
        "name": "summary",
        "maps_to": "oncology_sbml_galante2012_b7_h1_and_a_mathematical_model_for_c_biomd0000000812_model.summary",
        "description": "Change and peak summary across the simulated SBML observables."
      },
      {
        "name": "species_labels",
        "maps_to": "oncology_sbml_galante2012_b7_h1_and_a_mathematical_model_for_c_biomd0000000812_model.species_labels",
        "description": "Mapping from selected raw SBML observable symbols to display labels."
      }
    ]
  },
  "tags": [
    "biomodels_ebi",
    "curated",
    "drug-response",
    "faithful",
    "immunology",
    "immunotherapy",
    "microenvironment",
    "oncology",
    "pharmacology",
    "physiology",
    "sbml",
    "systemsbiology",
    "tumor-growth"
  ],
  "title": "Galante2012 - B7-H1 and a Mathematical Model for Cytotoxic T Cell and Tumor Cell Interaction Lab",
  "models": [
    {
      "path": "owned/models/oncology_sbml_galante2012_b7_h1_and_a_mathematical_model_for_c_biomd0000000812_model",
      "alias": "oncology_sbml_galante2012_b7_h1_and_a_mathematical_model_for_c_biomd0000000812_model",
      "provenance": {
        "owned_path": "owned/models/oncology_sbml_galante2012_b7_h1_and_a_mathematical_model_for_c_biomd0000000812_model"
      }
    },
    {
      "path": "owned/models/visualisation",
      "alias": "visualisation",
      "provenance": {
        "owned_path": "owned/models/visualisation"
      }
    }
  ],
  "wiring": [
    {
      "to": [
        "visualisation.oncology_sbml_galante2012_b7_h1_and_a_mathematical_model_for_c_biomd0000000812_model_state"
      ],
      "from": "oncology_sbml_galante2012_b7_h1_and_a_mathematical_model_for_c_biomd0000000812_model.state"
    },
    {
      "to": [
        "visualisation.oncology_sbml_galante2012_b7_h1_and_a_mathematical_model_for_c_biomd0000000812_model_summary"
      ],
      "from": "oncology_sbml_galante2012_b7_h1_and_a_mathematical_model_for_c_biomd0000000812_model.summary"
    },
    {
      "to": [
        "visualisation.oncology_sbml_galante2012_b7_h1_and_a_mathematical_model_for_c_biomd0000000812_model_species_labels"
      ],
      "from": "oncology_sbml_galante2012_b7_h1_and_a_mathematical_model_for_c_biomd0000000812_model.species_labels"
    }
  ],
  "runtime": {
    "duration": 10,
    "initial_inputs": {},
    "communication_step": 1
  },
  "description": "This is a mathematical model that describes the interactions between cytotoxic T cells and tumor cells as influenced by B7-H1 (PD-L1) activity, with a focus on how B7-H1 affects cancer cells apoptosis. It can be used to explore tumor-related dynamics and compare treatment-response behavior across conditions.",
  "schema_version": "2.0"
}