About lab
Palmer2008 - Negative Feedback in IL-7 mediated Jak-Stat signaling Lab
Curated immunology lab using the bundled source model as the scientific source of truth.
What You'll See
This captured run documents the default Palmer2008 - Negative Feedback in IL-7 mediated Jak-Stat signaling configuration for 10.0 time units with a 1.0 communication step. Default inputs include Initial Interleukin 7 Receptor Jak1 Stat5 Complex, Initial Interleukin 7 Receptor Jak1 Complex, Initial Interleukin 7 Receptor Jak1, and Initial Phosphorylated Interleukin 7 Receptor Jak1 Complex. Reported outputs include interleukin_7_receptor_jak1_stat5_complex, interleukin_7_receptor_jak1_complex, interleukin_7_receptor_jak1, and phosphorylated_interleukin_7_receptor_jak1_complex. The screenshots below pair the run-interpretation table with Immune signaling activity and Largest state excursions so the README shows both trajectories and the strongest state changes from the same dark-mode run.
Output Visualizations
The run-interpretation table summarizes the configured Palmer2008 - Negative Feedback in IL-7 mediated Jak-Stat signaling simulation and its final-state diagnostics.
The Immune signaling activity time series follows the selected immune, pathogen, tumor, or signaling quantities across the simulated horizon.
The largest state excursions chart ranks the state variables that moved furthest during the run.
Interleukin-7 (IL-7) is an essential cytokine for the development and homeostatic maintenance of T and B lymphocytes. Binding of IL-7 to its cognate receptor, the IL-7 receptor (IL-7R), activates mult.
Runtime
Runs
Metadata
Manifest
{
"io": {
"inputs": [
{
"name": "initial_interleukin_7_receptor_jak1_stat5_complex",
"label": "Initial Interleukin 7 Receptor Jak1 Stat5 Complex",
"units": "substance",
"default": 0,
"maps_to": "immunology_sbml_palmer2008_negative_feedback_in_il_7_mediated_ja_biomd0000000968_model.initial_interleukin_7_receptor_jak1_stat5_complex",
"description": "Initial Interleukin 7 Receptor Jak1 Stat5 Complex. Sets the initial value of bundled SBML species `IL7IL7RpJAK1STAT5`."
},
{
"name": "initial_interleukin_7_receptor_jak1_complex",
"label": "Initial Interleukin 7 Receptor Jak1 Complex",
"units": "substance",
"default": 0,
"maps_to": "immunology_sbml_palmer2008_negative_feedback_in_il_7_mediated_ja_biomd0000000968_model.initial_interleukin_7_receptor_jak1_complex",
"description": "Initial Interleukin 7 Receptor Jak1 Complex. Sets the initial value of bundled SBML species `IL7IL7RJAK1`."
},
{
"name": "initial_interleukin_7_receptor_jak1",
"label": "Initial Interleukin 7 Receptor Jak1",
"units": "substance",
"default": 1.66053904042716,
"maps_to": "immunology_sbml_palmer2008_negative_feedback_in_il_7_mediated_ja_biomd0000000968_model.initial_interleukin_7_receptor_jak1",
"description": "Initial Interleukin 7 Receptor Jak1. Sets the initial value of bundled SBML species `IL7RJAK1`."
},
{
"name": "initial_phosphorylated_interleukin_7_receptor_jak1_complex",
"label": "Initial Phosphorylated Interleukin 7 Receptor Jak1 Complex",
"units": "substance",
"default": 0,
"maps_to": "immunology_sbml_palmer2008_negative_feedback_in_il_7_mediated_ja_biomd0000000968_model.initial_phosphorylated_interleukin_7_receptor_jak1_complex",
"description": "Initial Phosphorylated Interleukin 7 Receptor Jak1 Complex. Sets the initial value of bundled SBML species `IL7IL7RpJAK1`."
},
{
"name": "initial_interleukin_7_receptor_jak1_socs1_complex",
"label": "Initial Interleukin 7 Receptor Jak1 Socs1 Complex",
"units": "substance",
"default": 0,
"maps_to": "immunology_sbml_palmer2008_negative_feedback_in_il_7_mediated_ja_biomd0000000968_model.initial_interleukin_7_receptor_jak1_socs1_complex",
"description": "Initial Interleukin 7 Receptor Jak1 Socs1 Complex. Sets the initial value of bundled SBML species `IL7IL7RpJAK1SOCS1`."
}
],
"outputs": [
{
"name": "interleukin_7_receptor_jak1_stat5_complex",
"maps_to": "immunology_sbml_palmer2008_negative_feedback_in_il_7_mediated_ja_biomd0000000968_model.interleukin_7_receptor_jak1_stat5_complex"
},
{
"name": "interleukin_7_receptor_jak1_complex",
"maps_to": "immunology_sbml_palmer2008_negative_feedback_in_il_7_mediated_ja_biomd0000000968_model.interleukin_7_receptor_jak1_complex"
},
{
"name": "interleukin_7_receptor_jak1",
"maps_to": "immunology_sbml_palmer2008_negative_feedback_in_il_7_mediated_ja_biomd0000000968_model.interleukin_7_receptor_jak1"
},
{
"name": "phosphorylated_interleukin_7_receptor_jak1_complex",
"maps_to": "immunology_sbml_palmer2008_negative_feedback_in_il_7_mediated_ja_biomd0000000968_model.phosphorylated_interleukin_7_receptor_jak1_complex"
},
{
"name": "interleukin_7_receptor_jak1_socs1_complex",
"maps_to": "immunology_sbml_palmer2008_negative_feedback_in_il_7_mediated_ja_biomd0000000968_model.interleukin_7_receptor_jak1_socs1_complex"
},
{
"name": "state",
"maps_to": "immunology_sbml_palmer2008_negative_feedback_in_il_7_mediated_ja_biomd0000000968_model.state"
},
{
"name": "summary",
"maps_to": "immunology_sbml_palmer2008_negative_feedback_in_il_7_mediated_ja_biomd0000000968_model.summary"
},
{
"name": "species_labels",
"maps_to": "immunology_sbml_palmer2008_negative_feedback_in_il_7_mediated_ja_biomd0000000968_model.species_labels"
}
]
},
"title": "Palmer2008 - Negative Feedback in IL-7 mediated Jak-Stat signaling Lab",
"models": [
{
"path": "owned/models/immunology_sbml_palmer2008_negative_feedback_in_il_7_mediated_ja_biomd0000000968_model",
"alias": "immunology_sbml_palmer2008_negative_feedback_in_il_7_mediated_ja_biomd0000000968_model",
"provenance": {
"owned_path": "owned/models/immunology_sbml_palmer2008_negative_feedback_in_il_7_mediated_ja_biomd0000000968_model"
}
},
{
"path": "owned/models/visualisation",
"alias": "visualisation",
"provenance": {
"owned_path": "owned/models/visualisation"
}
}
],
"wiring": [
{
"to": [
"visualisation.immunology_sbml_palmer2008_negative_feedback_in_il_7_mediated_ja_biomd0000000968_model_state"
],
"from": "immunology_sbml_palmer2008_negative_feedback_in_il_7_mediated_ja_biomd0000000968_model.state"
},
{
"to": [
"visualisation.immunology_sbml_palmer2008_negative_feedback_in_il_7_mediated_ja_biomd0000000968_model_summary"
],
"from": "immunology_sbml_palmer2008_negative_feedback_in_il_7_mediated_ja_biomd0000000968_model.summary"
},
{
"to": [
"visualisation.immunology_sbml_palmer2008_negative_feedback_in_il_7_mediated_ja_biomd0000000968_model_species_labels"
],
"from": "immunology_sbml_palmer2008_negative_feedback_in_il_7_mediated_ja_biomd0000000968_model.species_labels"
}
],
"runtime": {
"duration": 10,
"initial_inputs": {},
"communication_step": 1
},
"description": "Interleukin-7 (IL-7) is an essential cytokine for the development and homeostatic maintenance of T and B lymphocytes. Binding of IL-7 to its cognate receptor, the IL-7 receptor (IL-7R), activates mult.",
"schema_version": "2.0"
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