Kronik2008 - Improving alloreactive CTL immunotherapy for malignant gliomas using a simulation model of their interactive dynamics Lab

{
  "io": {
    "inputs": [
      {
        "name": "initial_unresolved_tumor_observable_1",
        "label": "Initial Unresolved Tumor Observable 1",
        "units": "native source value",
        "default": 10000000000,
        "maps_to": "immunology_sbml_kronik2008_improving_alloreactive_ctl_immunother_biomd0000000808_model.initial_unresolved_tumor_observable_1",
        "description": "Initial Unresolved Tumor Observable 1. Sets the initial value of bundled SBML species `T`."
      },
      {
        "name": "initial_unresolved_tumor_observable_2",
        "label": "Initial Unresolved Tumor Observable 2",
        "units": "native source value",
        "default": 2000000,
        "maps_to": "immunology_sbml_kronik2008_improving_alloreactive_ctl_immunother_biomd0000000808_model.initial_unresolved_tumor_observable_2",
        "description": "Initial Unresolved Tumor Observable 2. Sets the initial value of bundled SBML species `C`."
      },
      {
        "name": "initial_unresolved_tumor_observable_3",
        "label": "Initial Unresolved Tumor Observable 3",
        "units": "native source value",
        "default": 0,
        "maps_to": "immunology_sbml_kronik2008_improving_alloreactive_ctl_immunother_biomd0000000808_model.initial_unresolved_tumor_observable_3",
        "description": "Initial Unresolved Tumor Observable 3. Sets the initial value of bundled SBML species `F_beta`."
      },
      {
        "name": "initial_unresolved_tumor_observable_4",
        "label": "Initial Unresolved Tumor Observable 4",
        "units": "native source value",
        "default": 0,
        "maps_to": "immunology_sbml_kronik2008_improving_alloreactive_ctl_immunother_biomd0000000808_model.initial_unresolved_tumor_observable_4",
        "description": "Initial Unresolved Tumor Observable 4. Sets the initial value of bundled SBML species `F_gamma`."
      },
      {
        "name": "initial_unresolved_tumor_observable_5",
        "label": "Initial Unresolved Tumor Observable 5",
        "units": "native source value",
        "default": 0,
        "maps_to": "immunology_sbml_kronik2008_improving_alloreactive_ctl_immunother_biomd0000000808_model.initial_unresolved_tumor_observable_5",
        "description": "Initial Unresolved Tumor Observable 5. Sets the initial value of bundled SBML species `M1`."
      },
      {
        "name": "tumor_growth_rate",
        "label": "Tumor Growth Rate",
        "units": "native source value",
        "default": 0.00035,
        "maps_to": "immunology_sbml_kronik2008_improving_alloreactive_ctl_immunother_biomd0000000808_model.tumor_growth_rate",
        "description": "Tumor Growth Rate. Sets bundled SBML parameter `r`."
      },
      {
        "name": "s_dose",
        "label": "S Dose",
        "units": "native source value",
        "default": 300000000,
        "maps_to": "immunology_sbml_kronik2008_improving_alloreactive_ctl_immunother_biomd0000000808_model.s_dose",
        "description": "S Dose. Sets bundled SBML parameter `S_dose`."
      },
      {
        "name": "s_dose_initial_parameter",
        "label": "S Dose Initial Parameter",
        "units": "native source value",
        "default": 300000000,
        "maps_to": "immunology_sbml_kronik2008_improving_alloreactive_ctl_immunother_biomd0000000808_model.s_dose_initial_parameter",
        "description": "S Dose Initial Parameter. Sets bundled SBML parameter `ModelValue_28`."
      }
    ],
    "outputs": [
      {
        "name": "unresolved_tumor_observable_1",
        "maps_to": "immunology_sbml_kronik2008_improving_alloreactive_ctl_immunother_biomd0000000808_model.unresolved_tumor_observable_1"
      },
      {
        "name": "unresolved_tumor_observable_2",
        "maps_to": "immunology_sbml_kronik2008_improving_alloreactive_ctl_immunother_biomd0000000808_model.unresolved_tumor_observable_2"
      },
      {
        "name": "unresolved_tumor_observable_3",
        "maps_to": "immunology_sbml_kronik2008_improving_alloreactive_ctl_immunother_biomd0000000808_model.unresolved_tumor_observable_3"
      },
      {
        "name": "unresolved_tumor_observable_4",
        "maps_to": "immunology_sbml_kronik2008_improving_alloreactive_ctl_immunother_biomd0000000808_model.unresolved_tumor_observable_4"
      },
      {
        "name": "unresolved_tumor_observable_5",
        "maps_to": "immunology_sbml_kronik2008_improving_alloreactive_ctl_immunother_biomd0000000808_model.unresolved_tumor_observable_5"
      },
      {
        "name": "state",
        "maps_to": "immunology_sbml_kronik2008_improving_alloreactive_ctl_immunother_biomd0000000808_model.state"
      },
      {
        "name": "summary",
        "maps_to": "immunology_sbml_kronik2008_improving_alloreactive_ctl_immunother_biomd0000000808_model.summary"
      },
      {
        "name": "species_labels",
        "maps_to": "immunology_sbml_kronik2008_improving_alloreactive_ctl_immunother_biomd0000000808_model.species_labels"
      }
    ]
  },
  "title": "Kronik2008 - Improving alloreactive CTL immunotherapy for malignant gliomas using a simulation model of their interactive dynamics Lab",
  "models": [
    {
      "path": "owned/models/immunology_sbml_kronik2008_improving_alloreactive_ctl_immunother_biomd0000000808_model",
      "alias": "immunology_sbml_kronik2008_improving_alloreactive_ctl_immunother_biomd0000000808_model",
      "provenance": {
        "owned_path": "owned/models/immunology_sbml_kronik2008_improving_alloreactive_ctl_immunother_biomd0000000808_model"
      }
    },
    {
      "path": "owned/models/visualisation",
      "alias": "visualisation",
      "provenance": {
        "owned_path": "owned/models/visualisation"
      }
    }
  ],
  "wiring": [
    {
      "to": [
        "visualisation.immunology_sbml_kronik2008_improving_alloreactive_ctl_immunother_biomd0000000808_model_state"
      ],
      "from": "immunology_sbml_kronik2008_improving_alloreactive_ctl_immunother_biomd0000000808_model.state"
    },
    {
      "to": [
        "visualisation.immunology_sbml_kronik2008_improving_alloreactive_ctl_immunother_biomd0000000808_model_summary"
      ],
      "from": "immunology_sbml_kronik2008_improving_alloreactive_ctl_immunother_biomd0000000808_model.summary"
    },
    {
      "to": [
        "visualisation.immunology_sbml_kronik2008_improving_alloreactive_ctl_immunother_biomd0000000808_model_species_labels"
      ],
      "from": "immunology_sbml_kronik2008_improving_alloreactive_ctl_immunother_biomd0000000808_model.species_labels"
    }
  ],
  "runtime": {
    "duration": 10,
    "initial_inputs": {},
    "communication_step": 1
  },
  "description": "This mathematical model describes interactions between glioma tumors and the immune system that may occur following direct intra-tumoral administration of ex-vivo activated alloreactive cytotoxic-T-ly. It can be used to explore immune response dynamics and compare pathway-level behavior across conditions.",
  "schema_version": "2.0"
}