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Manchanda2014 - Effect on Immune System by 4 different Influenza A virus strains Lab

About lab

Himanshu Manchanda, Nora Seidel, Andi Krumbholz, Andreas Sauerbrei, Michaela Schmidtke & Reinhard Guthke. Within-host influenza dynamics: a small-scale mathematical modeling approach.

Runtime

Duration10
Comms Step1

Runs

Total0
Completed0
Failed0

Metadata

Packagemanchanda2014-effect-on-immune-system-by-4-different-influenza-a
Created2026-05-15
Updated2026-05-15
immunologysbmlbiomodels_ebifaithfulcuratedvisualisation

Manifest

{
  "io": {
    "inputs": [
      {
        "name": "initial_virus_pathogenicity_p",
        "label": "Initial Virus Pathogenicity P",
        "units": "native source value",
        "default": 0.01,
        "maps_to": "immunology_sbml_manchanda2014_effect_on_immune_system_by_4_diffe_biomd0000000712_model.initial_virus_pathogenicity_p",
        "description": "Initial Virus Pathogenicity P. Sets the initial value of bundled SBML species `P`."
      },
      {
        "name": "initial_antiviral_immune_defense_d",
        "label": "Initial Antiviral Immune Defense D",
        "units": "native source value",
        "default": 0,
        "maps_to": "immunology_sbml_manchanda2014_effect_on_immune_system_by_4_diffe_biomd0000000712_model.initial_antiviral_immune_defense_d",
        "description": "Initial Antiviral Immune Defense D. Sets the initial value of bundled SBML species `D`."
      },
      {
        "name": "initial_inflammation_i",
        "label": "Initial Inflammation I",
        "units": "native source value",
        "default": 0,
        "maps_to": "immunology_sbml_manchanda2014_effect_on_immune_system_by_4_diffe_biomd0000000712_model.initial_inflammation_i",
        "description": "Initial Inflammation I. Sets the initial value of bundled SBML species `I`."
      },
      {
        "name": "infection_of_virus_rate",
        "label": "Infection Of Virus Rate",
        "units": "native source value",
        "default": 3.63,
        "maps_to": "immunology_sbml_manchanda2014_effect_on_immune_system_by_4_diffe_biomd0000000712_model.infection_of_virus_rate",
        "description": "Infection Of Virus Rate. Sets bundled SBML parameter `alpha`."
      }
    ],
    "outputs": [
      {
        "name": "virus_pathogenicity_p",
        "maps_to": "immunology_sbml_manchanda2014_effect_on_immune_system_by_4_diffe_biomd0000000712_model.virus_pathogenicity_p"
      },
      {
        "name": "antiviral_immune_defense_d",
        "maps_to": "immunology_sbml_manchanda2014_effect_on_immune_system_by_4_diffe_biomd0000000712_model.antiviral_immune_defense_d"
      },
      {
        "name": "inflammation_i",
        "maps_to": "immunology_sbml_manchanda2014_effect_on_immune_system_by_4_diffe_biomd0000000712_model.inflammation_i"
      },
      {
        "name": "clinical_score_s",
        "maps_to": "immunology_sbml_manchanda2014_effect_on_immune_system_by_4_diffe_biomd0000000712_model.clinical_score_s"
      },
      {
        "name": "state",
        "maps_to": "immunology_sbml_manchanda2014_effect_on_immune_system_by_4_diffe_biomd0000000712_model.state"
      },
      {
        "name": "summary",
        "maps_to": "immunology_sbml_manchanda2014_effect_on_immune_system_by_4_diffe_biomd0000000712_model.summary"
      },
      {
        "name": "species_labels",
        "maps_to": "immunology_sbml_manchanda2014_effect_on_immune_system_by_4_diffe_biomd0000000712_model.species_labels"
      }
    ]
  },
  "title": "Manchanda2014 - Effect on Immune System by 4 different Influenza A virus strains Lab",
  "models": [
    {
      "path": "owned/models/immunology_sbml_manchanda2014_effect_on_immune_system_by_4_diffe_biomd0000000712_model",
      "alias": "immunology_sbml_manchanda2014_effect_on_immune_system_by_4_diffe_biomd0000000712_model",
      "provenance": {
        "owned_path": "owned/models/immunology_sbml_manchanda2014_effect_on_immune_system_by_4_diffe_biomd0000000712_model"
      }
    },
    {
      "path": "owned/models/visualisation",
      "alias": "visualisation",
      "provenance": {
        "owned_path": "owned/models/visualisation"
      }
    }
  ],
  "wiring": [
    {
      "to": [
        "visualisation.immunology_sbml_manchanda2014_effect_on_immune_system_by_4_diffe_biomd0000000712_model_state"
      ],
      "from": "immunology_sbml_manchanda2014_effect_on_immune_system_by_4_diffe_biomd0000000712_model.state"
    },
    {
      "to": [
        "visualisation.immunology_sbml_manchanda2014_effect_on_immune_system_by_4_diffe_biomd0000000712_model_summary"
      ],
      "from": "immunology_sbml_manchanda2014_effect_on_immune_system_by_4_diffe_biomd0000000712_model.summary"
    },
    {
      "to": [
        "visualisation.immunology_sbml_manchanda2014_effect_on_immune_system_by_4_diffe_biomd0000000712_model_species_labels"
      ],
      "from": "immunology_sbml_manchanda2014_effect_on_immune_system_by_4_diffe_biomd0000000712_model.species_labels"
    }
  ],
  "runtime": {
    "duration": 10,
    "initial_inputs": {},
    "communication_step": 1
  },
  "description": "Himanshu Manchanda, Nora Seidel, Andi Krumbholz, Andreas Sauerbrei, Michaela Schmidtke & Reinhard Guthke. Within-host influenza dynamics: a small-scale mathematical modeling approach.",
  "schema_version": "2.0"
}

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