About lab
This is a ordinary differential equation mathematical model describing the Rho GTPase cycle in which Rho GDP-dissociation inhibitors (RhoGDIs) inhibit the regulatory activities of guanine nucleotide e. It can be used to explore systemsbiology ota2015 positive regulation of rho dynamics and compare simulation behavior across conditions.
Runtime
Duration1
Comms Step0.1
Runs
Total0
Completed0
Failed0
Metadata
Packageota2015-positive-regulation-of-rho-gtpase-activity-by-rhogdis-as
Created2026-05-17
Updated2026-05-17
pharmacologysystemsbiologysbmlbiomodels_ebifaithfulcuratedvisualisation
Manifest
{
"io": {
"inputs": [
{
"name": "initial_gdigdp_rho",
"label": "Initial Gdigdp Rho",
"maps_to": "systemsbiology_sbml_ota2015_positive_regulation_of_rho_gtpase_activi_biomd0000000899_model.initial_gdigdp_rho",
"description": "Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol `s10`."
},
{
"name": "initial_effector",
"label": "Initial Effector",
"maps_to": "systemsbiology_sbml_ota2015_positive_regulation_of_rho_gtpase_activi_biomd0000000899_model.initial_effector",
"description": "Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol `s9`."
},
{
"name": "initial_activator",
"label": "Initial Activator",
"maps_to": "systemsbiology_sbml_ota2015_positive_regulation_of_rho_gtpase_activi_biomd0000000899_model.initial_activator",
"description": "Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol `s1`."
},
{
"name": "initial_model_state_gef",
"label": "Initial Model State Gef",
"maps_to": "systemsbiology_sbml_ota2015_positive_regulation_of_rho_gtpase_activi_biomd0000000899_model.initial_model_state_gef",
"description": "Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol `s3`."
},
{
"name": "initial_model_state_gap",
"label": "Initial Model State Gap",
"maps_to": "systemsbiology_sbml_ota2015_positive_regulation_of_rho_gtpase_activi_biomd0000000899_model.initial_model_state_gap",
"description": "Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol `s8`."
},
{
"name": "initial_gtp_rho",
"label": "Initial Gtp Rho",
"maps_to": "systemsbiology_sbml_ota2015_positive_regulation_of_rho_gtpase_activi_biomd0000000899_model.initial_gtp_rho",
"description": "Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol `s6`."
}
],
"outputs": [
{
"name": "state",
"maps_to": "systemsbiology_sbml_ota2015_positive_regulation_of_rho_gtpase_activi_biomd0000000899_model.state"
},
{
"name": "summary",
"maps_to": "systemsbiology_sbml_ota2015_positive_regulation_of_rho_gtpase_activi_biomd0000000899_model.summary"
},
{
"name": "species_labels",
"maps_to": "systemsbiology_sbml_ota2015_positive_regulation_of_rho_gtpase_activi_biomd0000000899_model.species_labels"
},
{
"name": "gdigdp_rho",
"maps_to": "systemsbiology_sbml_ota2015_positive_regulation_of_rho_gtpase_activi_biomd0000000899_model.gdigdp_rho"
},
{
"name": "effector",
"maps_to": "systemsbiology_sbml_ota2015_positive_regulation_of_rho_gtpase_activi_biomd0000000899_model.effector"
},
{
"name": "activator",
"maps_to": "systemsbiology_sbml_ota2015_positive_regulation_of_rho_gtpase_activi_biomd0000000899_model.activator"
},
{
"name": "gef",
"maps_to": "systemsbiology_sbml_ota2015_positive_regulation_of_rho_gtpase_activi_biomd0000000899_model.gef"
},
{
"name": "gap",
"maps_to": "systemsbiology_sbml_ota2015_positive_regulation_of_rho_gtpase_activi_biomd0000000899_model.gap"
},
{
"name": "gtp_rho",
"maps_to": "systemsbiology_sbml_ota2015_positive_regulation_of_rho_gtpase_activi_biomd0000000899_model.gtp_rho"
}
]
},
"tags": [
"pharmacology",
"systemsbiology",
"sbml",
"biomodels_ebi",
"faithful",
"curated"
],
"title": "Ota2015 Positive Regulation Of Rho Gtpase Activity By Rhogdis As A Lab",
"models": [
{
"path": "owned/models/systemsbiology_sbml_ota2015_positive_regulation_of_rho_gtpase_activi_biomd0000000899_model",
"alias": "systemsbiology_sbml_ota2015_positive_regulation_of_rho_gtpase_activi_biomd0000000899_model",
"provenance": {
"owned_path": "owned/models/systemsbiology_sbml_ota2015_positive_regulation_of_rho_gtpase_activi_biomd0000000899_model"
}
},
{
"path": "owned/models/visualisation",
"alias": "visualisation",
"provenance": {
"owned_path": "owned/models/visualisation"
}
}
],
"wiring": [
{
"to": [
"visualisation.systemsbiology_sbml_ota2015_positive_regulation_of_rho_gtpase_activi_biomd0000000899_model_state"
],
"from": "systemsbiology_sbml_ota2015_positive_regulation_of_rho_gtpase_activi_biomd0000000899_model.state"
},
{
"to": [
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],
"from": "systemsbiology_sbml_ota2015_positive_regulation_of_rho_gtpase_activi_biomd0000000899_model.summary"
},
{
"to": [
"visualisation.systemsbiology_sbml_ota2015_positive_regulation_of_rho_gtpase_activi_biomd0000000899_model_species_labels"
],
"from": "systemsbiology_sbml_ota2015_positive_regulation_of_rho_gtpase_activi_biomd0000000899_model.species_labels"
}
],
"runtime": {
"duration": 1,
"initial_inputs": {},
"communication_step": 0.1
},
"description": "This is a ordinary differential equation mathematical model describing the Rho GTPase cycle in which Rho GDP-dissociation inhibitors (RhoGDIs) inhibit the regulatory activities of guanine nucleotide e. It can be used to explore systemsbiology ota2015 positive regulation of rho dynamics and compare simulation behavior across conditions.",
"schema_version": "2.0"
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