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Legewie2006 Apoptosis Wt Lab

About lab

The model reproduces active Caspase-3 time profile corresponding to the total Apaf-1 value of 20 nM as depicted in Fig 2-A . It can be used to explore systemsbiology legewie2006 apoptosis wt BioModels0000000102 dynamics and compare simulation behavior across conditions.

Runtime

Duration1
Comms Step0.1

Runs

Total0
Completed0
Failed0

Metadata

Packagelegewie2006-apoptosis-wt-lab
Created2026-05-17
Updated2026-05-17
systemsbiologysbmlbiomodels_ebifaithfulcuratedvisualisation

Manifest

{
  "io": {
    "inputs": [
      {
        "name": "initial_caspase_3",
        "label": "Initial Caspase 3",
        "maps_to": "systemsbiology_sbml_legewie2006_apoptosis_wt_biomd0000000102_model.initial_caspase_3",
        "description": "Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol `C3`."
      },
      {
        "name": "initial_caspase_9",
        "label": "Initial Caspase 9",
        "maps_to": "systemsbiology_sbml_legewie2006_apoptosis_wt_biomd0000000102_model.initial_caspase_9",
        "description": "Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol `C9`."
      },
      {
        "name": "initial_caspase_9_xiap_complex",
        "label": "Initial Caspase 9 Xiap Complex",
        "maps_to": "systemsbiology_sbml_legewie2006_apoptosis_wt_biomd0000000102_model.initial_caspase_9_xiap_complex",
        "description": "Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol `C9X`."
      },
      {
        "name": "initial_caspase_9_cleaved_xiap_complex",
        "label": "Initial Caspase 9 Cleaved Xiap Complex",
        "maps_to": "systemsbiology_sbml_legewie2006_apoptosis_wt_biomd0000000102_model.initial_caspase_9_cleaved_xiap_complex",
        "description": "Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol `C9_starX`."
      },
      {
        "name": "initial_caspase_9_cleaved",
        "label": "Initial Caspase 9 Cleaved",
        "maps_to": "systemsbiology_sbml_legewie2006_apoptosis_wt_biomd0000000102_model.initial_caspase_9_cleaved",
        "description": "Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol `C9_star`."
      },
      {
        "name": "initial_caspase_3_cleaved_xiap_complex",
        "label": "Initial Caspase 3 Cleaved Xiap Complex",
        "maps_to": "systemsbiology_sbml_legewie2006_apoptosis_wt_biomd0000000102_model.initial_caspase_3_cleaved_xiap_complex",
        "description": "Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol `C3_starX`."
      }
    ],
    "outputs": [
      {
        "name": "state",
        "maps_to": "systemsbiology_sbml_legewie2006_apoptosis_wt_biomd0000000102_model.state"
      },
      {
        "name": "summary",
        "maps_to": "systemsbiology_sbml_legewie2006_apoptosis_wt_biomd0000000102_model.summary"
      },
      {
        "name": "species_labels",
        "maps_to": "systemsbiology_sbml_legewie2006_apoptosis_wt_biomd0000000102_model.species_labels"
      },
      {
        "name": "caspase_3",
        "maps_to": "systemsbiology_sbml_legewie2006_apoptosis_wt_biomd0000000102_model.caspase_3"
      },
      {
        "name": "caspase_9",
        "maps_to": "systemsbiology_sbml_legewie2006_apoptosis_wt_biomd0000000102_model.caspase_9"
      },
      {
        "name": "caspase_9_xiap_complex",
        "maps_to": "systemsbiology_sbml_legewie2006_apoptosis_wt_biomd0000000102_model.caspase_9_xiap_complex"
      },
      {
        "name": "caspase_9_cleaved_xiap_complex",
        "maps_to": "systemsbiology_sbml_legewie2006_apoptosis_wt_biomd0000000102_model.caspase_9_cleaved_xiap_complex"
      },
      {
        "name": "caspase_9_cleaved",
        "maps_to": "systemsbiology_sbml_legewie2006_apoptosis_wt_biomd0000000102_model.caspase_9_cleaved"
      },
      {
        "name": "caspase_3_cleaved_xiap_complex",
        "maps_to": "systemsbiology_sbml_legewie2006_apoptosis_wt_biomd0000000102_model.caspase_3_cleaved_xiap_complex"
      }
    ]
  },
  "tags": [
    "systemsbiology",
    "sbml",
    "biomodels_ebi",
    "faithful",
    "curated"
  ],
  "title": "Legewie2006 Apoptosis Wt Lab",
  "models": [
    {
      "path": "owned/models/systemsbiology_sbml_legewie2006_apoptosis_wt_biomd0000000102_model",
      "alias": "systemsbiology_sbml_legewie2006_apoptosis_wt_biomd0000000102_model",
      "provenance": {
        "owned_path": "owned/models/systemsbiology_sbml_legewie2006_apoptosis_wt_biomd0000000102_model"
      }
    },
    {
      "path": "owned/models/visualisation",
      "alias": "visualisation",
      "provenance": {
        "owned_path": "owned/models/visualisation"
      }
    }
  ],
  "wiring": [
    {
      "to": [
        "visualisation.systemsbiology_sbml_legewie2006_apoptosis_wt_biomd0000000102_model_state"
      ],
      "from": "systemsbiology_sbml_legewie2006_apoptosis_wt_biomd0000000102_model.state"
    },
    {
      "to": [
        "visualisation.systemsbiology_sbml_legewie2006_apoptosis_wt_biomd0000000102_model_summary"
      ],
      "from": "systemsbiology_sbml_legewie2006_apoptosis_wt_biomd0000000102_model.summary"
    },
    {
      "to": [
        "visualisation.systemsbiology_sbml_legewie2006_apoptosis_wt_biomd0000000102_model_species_labels"
      ],
      "from": "systemsbiology_sbml_legewie2006_apoptosis_wt_biomd0000000102_model.species_labels"
    }
  ],
  "runtime": {
    "duration": 1,
    "initial_inputs": {},
    "communication_step": 0.1
  },
  "description": "The model reproduces active Caspase-3 time profile corresponding to the total Apaf-1 value of 20 nM as depicted in Fig 2-A . It can be used to explore systemsbiology legewie2006 apoptosis wt BioModels0000000102 dynamics and compare simulation behavior across conditions.",
  "schema_version": "2.0"
}

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