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Immunological Healthy State Model of Sphingolipids with IL-6/IL-17/IL-23 immune axis in L.major infection Lab

About lab

In Healthy State, we demonstrated the controlled expression of sphingolipids and the controlled IL-6,IL-17,IL-23 cytokines signalling via SOCS3 mediated regulation. It can be used to explore immune response dynamics and compare pathway-level behavior across conditions.

Runtime

Duration10
Comms Step1

Runs

Total0
Completed0
Failed0

Metadata

Packageimmunological-healthy-state-model-of-sphingolipids-with-il-6-il
Created2026-05-15
Updated2026-05-15
immunologysbmlbiomodels_ebifaithfulcuratedvisualisation

Manifest

{
  "io": {
    "inputs": [
      {
        "name": "initial_lpg_toll_like_receptor_complex",
        "label": "Initial Lpg Toll Like Receptor Complex",
        "units": "MWBUILTINUNIT_molecule",
        "default": 1000,
        "maps_to": "immunology_sbml_immunological_healthy_state_model_of_sphingolipi_model2301110002_model.initial_lpg_toll_like_receptor_complex",
        "description": "Initial Lpg Toll Like Receptor Complex. Sets the initial value of bundled SBML species `mw3d4055f8_c490_4463_911f_eed820b1323c`."
      },
      {
        "name": "initial_unresolved_infection_observable_2",
        "label": "Initial Unresolved Infection Observable 2",
        "units": "MWBUILTINUNIT_molecule",
        "default": 3980,
        "maps_to": "immunology_sbml_immunological_healthy_state_model_of_sphingolipi_model2301110002_model.initial_unresolved_infection_observable_2",
        "description": "Initial Unresolved Infection Observable 2. Sets the initial value of bundled SBML species `mwc4164d07_8269_4b39_b8af_6c1b22eee1ea`."
      },
      {
        "name": "initial_irak1_irak4_complex",
        "label": "Initial Irak1 Irak4 Complex",
        "units": "MWBUILTINUNIT_molecule",
        "default": 2000,
        "maps_to": "immunology_sbml_immunological_healthy_state_model_of_sphingolipi_model2301110002_model.initial_irak1_irak4_complex",
        "description": "Initial Irak1 Irak4 Complex. Sets the initial value of bundled SBML species `mw21d5a961_4d66_4509_88cd_c983fa74e314`."
      }
    ],
    "outputs": [
      {
        "name": "unresolved_infection_observable_1",
        "maps_to": "immunology_sbml_immunological_healthy_state_model_of_sphingolipi_model2301110002_model.unresolved_infection_observable_1"
      },
      {
        "name": "toll_like_receptor",
        "maps_to": "immunology_sbml_immunological_healthy_state_model_of_sphingolipi_model2301110002_model.toll_like_receptor"
      },
      {
        "name": "lpg_toll_like_receptor_complex",
        "maps_to": "immunology_sbml_immunological_healthy_state_model_of_sphingolipi_model2301110002_model.lpg_toll_like_receptor_complex"
      },
      {
        "name": "unresolved_infection_observable_2",
        "maps_to": "immunology_sbml_immunological_healthy_state_model_of_sphingolipi_model2301110002_model.unresolved_infection_observable_2"
      },
      {
        "name": "irak1_irak4_complex",
        "maps_to": "immunology_sbml_immunological_healthy_state_model_of_sphingolipi_model2301110002_model.irak1_irak4_complex"
      },
      {
        "name": "state",
        "maps_to": "immunology_sbml_immunological_healthy_state_model_of_sphingolipi_model2301110002_model.state"
      },
      {
        "name": "summary",
        "maps_to": "immunology_sbml_immunological_healthy_state_model_of_sphingolipi_model2301110002_model.summary"
      },
      {
        "name": "species_labels",
        "maps_to": "immunology_sbml_immunological_healthy_state_model_of_sphingolipi_model2301110002_model.species_labels"
      }
    ]
  },
  "title": "Immunological Healthy State Model of Sphingolipids with IL-6/IL-17/IL-23 immune axis in L.major infection Lab",
  "models": [
    {
      "path": "owned/models/immunology_sbml_immunological_healthy_state_model_of_sphingolipi_model2301110002_model",
      "alias": "immunology_sbml_immunological_healthy_state_model_of_sphingolipi_model2301110002_model",
      "provenance": {
        "owned_path": "owned/models/immunology_sbml_immunological_healthy_state_model_of_sphingolipi_model2301110002_model"
      }
    },
    {
      "path": "owned/models/visualisation",
      "alias": "visualisation",
      "provenance": {
        "owned_path": "owned/models/visualisation"
      }
    }
  ],
  "wiring": [
    {
      "to": [
        "visualisation.immunology_sbml_immunological_healthy_state_model_of_sphingolipi_model2301110002_model_state"
      ],
      "from": "immunology_sbml_immunological_healthy_state_model_of_sphingolipi_model2301110002_model.state"
    },
    {
      "to": [
        "visualisation.immunology_sbml_immunological_healthy_state_model_of_sphingolipi_model2301110002_model_summary"
      ],
      "from": "immunology_sbml_immunological_healthy_state_model_of_sphingolipi_model2301110002_model.summary"
    },
    {
      "to": [
        "visualisation.immunology_sbml_immunological_healthy_state_model_of_sphingolipi_model2301110002_model_species_labels"
      ],
      "from": "immunology_sbml_immunological_healthy_state_model_of_sphingolipi_model2301110002_model.species_labels"
    }
  ],
  "runtime": {
    "duration": 10,
    "initial_inputs": {},
    "communication_step": 1
  },
  "description": "In Healthy State, we demonstrated the controlled expression of sphingolipids and the controlled IL-6,IL-17,IL-23 cytokines signalling via SOCS3 mediated regulation. It can be used to explore immune response dynamics and compare pathway-level behavior across conditions.",
  "schema_version": "2.0"
}

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