BiosimulantBiosimulant
Docs
Search labs...
Sign inGet Started

Loccisano2011-pharmacokinetics of PFOA and PFOS in the monkey Lab

About lab

Perfluoroalkyl acid carboxylates and sulfonates (PFAAs) have many consumer and industrial applications. The persistence and widespread distribution of these compounds in humans have brought them under.

Runtime

Duration24
Comms Step1

Runs

Total0
Completed0
Failed0

Metadata

Packageloccisano2011-pharmacokinetics-of-pfoa-and-pfos-in-the-monkey-la
Created2026-05-16
Updated2026-05-16
pharmacologytoxicologypharmacokineticspbpkphysiologysbmltelluriumfaithfulbiomodels_ebivisualisation

Manifest

{
  "io": {
    "inputs": [
      {
        "name": "oral_toxicant_input",
        "label": "Oral Toxicant Input",
        "maps_to": "pharmacology_sbml_loccisano2011_pharmacokinetics_of_pfoa_and_pfos_model2003190002_model.oral_toxicant_input"
      },
      {
        "name": "iv_toxicant_input",
        "label": "IV Toxicant Input",
        "maps_to": "pharmacology_sbml_loccisano2011_pharmacokinetics_of_pfoa_and_pfos_model2003190002_model.iv_toxicant_input"
      },
      {
        "name": "initial_plasma_toxicant_burden",
        "label": "Initial Plasma Toxicant Burden",
        "maps_to": "pharmacology_sbml_loccisano2011_pharmacokinetics_of_pfoa_and_pfos_model2003190002_model.initial_plasma_toxicant_burden"
      },
      {
        "name": "urinary_elimination_rate",
        "label": "Urinary Elimination Rate",
        "maps_to": "pharmacology_sbml_loccisano2011_pharmacokinetics_of_pfoa_and_pfos_model2003190002_model.urinary_elimination_rate"
      },
      {
        "name": "free_fraction",
        "label": "Free Fraction",
        "maps_to": "pharmacology_sbml_loccisano2011_pharmacokinetics_of_pfoa_and_pfos_model2003190002_model.free_fraction"
      }
    ],
    "outputs": [
      {
        "name": "state",
        "label": "Tracked source state",
        "maps_to": "pharmacology_sbml_loccisano2011_pharmacokinetics_of_pfoa_and_pfos_model2003190002_model.state"
      },
      {
        "name": "summary",
        "label": "Simulation summary",
        "maps_to": "pharmacology_sbml_loccisano2011_pharmacokinetics_of_pfoa_and_pfos_model2003190002_model.summary"
      },
      {
        "name": "species_labels",
        "label": "Observable labels",
        "maps_to": "pharmacology_sbml_loccisano2011_pharmacokinetics_of_pfoa_and_pfos_model2003190002_model.species_labels"
      },
      {
        "name": "plasma_toxicant_burden",
        "label": "Plasma Toxicant Burden",
        "maps_to": "pharmacology_sbml_loccisano2011_pharmacokinetics_of_pfoa_and_pfos_model2003190002_model.plasma_toxicant_burden"
      },
      {
        "name": "liver_toxicant_burden",
        "label": "Liver Toxicant Burden",
        "maps_to": "pharmacology_sbml_loccisano2011_pharmacokinetics_of_pfoa_and_pfos_model2003190002_model.liver_toxicant_burden"
      },
      {
        "name": "kidney_toxicant_burden",
        "label": "Kidney Toxicant Burden",
        "maps_to": "pharmacology_sbml_loccisano2011_pharmacokinetics_of_pfoa_and_pfos_model2003190002_model.kidney_toxicant_burden"
      },
      {
        "name": "gut_toxicant_burden",
        "label": "Gut Toxicant Burden",
        "maps_to": "pharmacology_sbml_loccisano2011_pharmacokinetics_of_pfoa_and_pfos_model2003190002_model.gut_toxicant_burden"
      },
      {
        "name": "fat_toxicant_burden",
        "label": "Fat Toxicant Burden",
        "maps_to": "pharmacology_sbml_loccisano2011_pharmacokinetics_of_pfoa_and_pfos_model2003190002_model.fat_toxicant_burden"
      },
      {
        "name": "skin_toxicant_burden",
        "label": "Skin Toxicant Burden",
        "maps_to": "pharmacology_sbml_loccisano2011_pharmacokinetics_of_pfoa_and_pfos_model2003190002_model.skin_toxicant_burden"
      },
      {
        "name": "urine_toxicant_burden",
        "label": "Urine Toxicant Burden",
        "maps_to": "pharmacology_sbml_loccisano2011_pharmacokinetics_of_pfoa_and_pfos_model2003190002_model.urine_toxicant_burden"
      },
      {
        "name": "filtrate_toxicant_burden",
        "label": "Filtrate Toxicant Burden",
        "maps_to": "pharmacology_sbml_loccisano2011_pharmacokinetics_of_pfoa_and_pfos_model2003190002_model.filtrate_toxicant_burden"
      }
    ]
  },
  "tags": [
    "pharmacology",
    "toxicology",
    "pharmacokinetics",
    "pbpk",
    "physiology",
    "sbml",
    "tellurium",
    "faithful",
    "biomodels_ebi"
  ],
  "title": "Loccisano2011-pharmacokinetics of PFOA and PFOS in the monkey Lab",
  "models": [
    {
      "path": "owned/models/pharmacology_sbml_loccisano2011_pharmacokinetics_of_pfoa_and_pfos_model2003190002_model",
      "alias": "pharmacology_sbml_loccisano2011_pharmacokinetics_of_pfoa_and_pfos_model2003190002_model",
      "parameters": {
        "model_path": "data/MODEL2003190002.xml",
        "integration_step": 0.1
      },
      "provenance": {
        "owned_path": "owned/models/pharmacology_sbml_loccisano2011_pharmacokinetics_of_pfoa_and_pfos_model2003190002_model"
      }
    },
    {
      "path": "owned/models/visualisation",
      "alias": "visualisation",
      "provenance": {
        "owned_path": "owned/models/visualisation"
      }
    }
  ],
  "wiring": [
    {
      "to": [
        "visualisation.pharmacology_sbml_loccisano2011_pharmacokinetics_of_pfoa_and_pfos_model2003190002_model_state"
      ],
      "from": "pharmacology_sbml_loccisano2011_pharmacokinetics_of_pfoa_and_pfos_model2003190002_model.state"
    },
    {
      "to": [
        "visualisation.pharmacology_sbml_loccisano2011_pharmacokinetics_of_pfoa_and_pfos_model2003190002_model_summary"
      ],
      "from": "pharmacology_sbml_loccisano2011_pharmacokinetics_of_pfoa_and_pfos_model2003190002_model.summary"
    },
    {
      "to": [
        "visualisation.pharmacology_sbml_loccisano2011_pharmacokinetics_of_pfoa_and_pfos_model2003190002_model_species_labels"
      ],
      "from": "pharmacology_sbml_loccisano2011_pharmacokinetics_of_pfoa_and_pfos_model2003190002_model.species_labels"
    }
  ],
  "runtime": {
    "duration": 24,
    "initial_inputs": {},
    "communication_step": 1
  },
  "description": "Perfluoroalkyl acid carboxylates and sulfonates (PFAAs) have many consumer and industrial applications. The persistence and widespread distribution of these compounds in humans have brought them under.",
  "schema_version": "2.0"
}

Sign in to start your own run. Public-lab history stays visible here.

Select a run from History to view its results.